AGGIORNAMENTO SCIENTIFICO IN TEMPO REALE FORNITO DA:

- Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysisby Yao Zhang on 6 Febbraio 2025
INTRODUCTION: Major depressive disorder with suicidal ideation (MDD/SI+) is characterized by high prevalence, high recurrence rate, high disability rate and low response rate. There is an urgent need for clarifying the pathogenesis and developing novel treatment methods.
- A cognitive neural circuit biotype of depression showing functional and behavioral improvement after transcranial magnetic stimulation in the B-SMART-fMRI trialby Leonardo Tozzi on 6 Febbraio 2025
We previously identified a cognitive biotype of depression characterized by treatment resistance, impaired cognitive control behavioral performance and dysfunction in the cognitive control circuit, comprising the dorsolateral prefrontal cortex (dLPFC) and dorsal anterior cingulate cortex (dACC). Therapeutic transcranial magnetic stimulation (TMS) to the left dLPFC is a promising option for individuals whose depression does not respond to pharmacotherapy. Here, 43 veterans with...
- Discrete Variational Autoencoders BERT Model-Based Transcranial focused ultrasound for Alzheimer's Disease Detectionby Kaushika Reddy Thipparthy on 5 Febbraio 2025
RESEARCH BACKGROUND: Alzheimer's Disease (AD) is a neurodegenerative condition marked by symptoms including aphasia and diminished verbal fluency. Researchers have employed phonetic attributes, fluency, pauses, and various paralinguistic traits, or derived aspects from transcribed text, to identify Alzheimer's disease.
- Pathway-dependent brain stimulation responses indicate motion processing integrity after strokeby Michele Bevilacqua on 4 Febbraio 2025
Homonymous Hemianopia (HH), a common visual impairment resulting from occipital lobe lesions, affects a significant number of stroke survivors. Intensive perceptual training can foster recovery, possibly by enhancing surviving visual pathways. This study employed cortico-cortical paired associative stimulation (ccPAS) to induce associative plasticity within the residual and bi-directional primary visual cortex (V1) - middle temporal area (MT) pathways in stroke patients. We used ccPAS, which is...
- Near-infrared spectroscopy-guided personalized repetitive transcranial magnetic stimulation for bipolar depression: a case reportby Chun-Hung Chang on 4 Febbraio 2025
CONCLUSION: Our case suggests that NIRS can guide the selection of appropriate TMS protocols for patients with bipolar depression. Although our findings are promising, further randomized controlled trials are needed to validate the efficacy and safety of and determine the optimal parameters for this approach.
- Neural circuit mapping of waiting impulsivity and proactive inhibition with convergent evidence from fMRI and TMSby Kwangyeol Baek on 4 Febbraio 2025
CONCLUSIONS: Our findings highlight the relevance of task design in assessing motor response inhibition and the role of the left inferior frontal gyrus integrity and related neural circuitry in waiting impulsivity and proactive stopping. We also leverage the use of convergent evidence from multi-modal investigation tools in addressing the causal neural areas underlying distinct forms of impulsivity.
- Discovery of E0199: A novel compound targeting both peripheral Na(V) and K(V)7 channels to alleviate neuropathic painby Boxuan Zhang on 5 Febbraio 2025
This research study focuses on addressing the limitations of current neuropathic pain (NP) treatments by developing a novel dual-target modulator, E0199, targeting both Na(V)1.7, Na(V)1.8, and Na(V)1.9 and K(V)7 channels, a crucial regulator in controlling NP symptoms. The objective of the study was to synthesize a compound capable of modulating these channels to alleviate NP. Through an experimental design involving both in vitro and in vivo methods, E0199 was tested for its efficacy on ion...
- PI3K-mediated Kif1a DNA methylation contributes to neuropathic pain: an in vivo studyby Wei Jiang on 5 Febbraio 2025
Neuropathic pain (NP) is a chronic condition caused by nerve injuries, such as nerve compression. Understanding its underlying neurobiological mechanisms is critical for developing effective treatments. Previous studies have shown that Kinesin family member 1A (Kif1a) heterozygous deficient mice display sensory deficits in response to nociceptive stimuli. PI3K has been found to mitigate these sensory deficits by enhancing Kif1a transcription, highlighting KIF1A's key role in sensory pain....
- Structural and dynamic characteristics in sonographic evaluation of the sciatic nerve in patients with probable neuropathic pain - A cross-sectional studyby Maria Alice Mainenti Pagnez on 5 Febbraio 2025
CONCLUSION: Participants with probable chronic neuropathic pain had similar CSA, ECHO, and SKN of the sciatic nerve between the symptomatic and asymptomatic lower limbs. Increasing sciatic nerve tension (position C) reduced CSA and caused superficial nerve displacement on both sides.
- Chronic postsurgical pain and transitional pain services: a narrative review highlighting European perspectivesby Eleni Moka on 5 Febbraio 2025
CONCLUSIONS: Future research should focus on large-scale studies integrating various factors to facilitate CPSP prediction, refine prevention strategies and reduce its long-term impact.
- Chronic postsurgical inguinal pain: incidence and diagnostic biomarkers from a large German national claims databaseby Eva Herrmann on 5 Febbraio 2025
CONCLUSIONS: CPIP is often newly acquired after surgery. A combination of DRG imaging, serum markers, and anxiety screening can support the diagnosis. In the future, this could guide clinicians towards more personalised therapies (e.g. targeting anxiety or lipid profiles) and possible altered surgical techniques.
- Can Spinal Cord Stimulation be Considered as a Frontier for Chronic Pain in Diabetic Foot?by Ying Zhang on 5 Febbraio 2025
Chronic pain in the diabetic foot (DF) is a common complication of diabetes, bringing a significant burden to patients, their families, and even society. There is no very effective treatment for it, traditional treatments such as medication, lumbar sympathetic nerve block, and alternative therapies are often not very effective and have more adverse effects. The emergence of neuromodulation technology has brought new hope for the treatment of DF, among which spinal cord stimulation (SCS) is a...
- Sleep quality during pregnancy following assisted reproductive technology and natural conceiving: a prospective birth cohort studyby Yidong Xie on 6 Febbraio 2025
CONCLUSION: The study reveals that women receiving IVF/ICSI treatment are at a higher risk of experiencing sleep disturbances throughout their pregnancy compared with women with natural conception. While partners typically do not report major sleep problems, they do exhibit increased anxiety levels. These findings underscore the necessity for screening and addressing sleep issues in women pregnant through assisted IVF/ICSI treatment, to promote their well-being during this critical period.
- Early harmonies, enduring echoes-how early life experiences and personality traits shape music performance anxietyby Ludivine Aubry on 6 Febbraio 2025
Music performance anxiety (MPA) is a deeply personal and often debilitating experience, causing talented musicians to dread the very stages upon which they showcase their art. An increasing number of studies have addressed this anxiety phenomenon, however, definitions vary and the underlying causes remain unclear. According to the DSM-5, MPA is categorized as a specific subtype of social anxiety disorder, with a shared understanding that its development is shaped by predisposing vulnerabilities...
- Neuron-Specific Glycine Metabolism Links Transfer RNA Epitranscriptomic Regulation to Complex Behaviorsby Jennifer Blaze on 6 Febbraio 2025
CONCLUSIONS: Alterations in neuronal glycine metabolism, resulting from targeted ablation of the glycine cleavage system or disruption of the tRNA regulome, elicit changes in complex behaviors in mice relevant for neuropsychiatric phenotypes.
- Mental health, sleep quality and quality of life in individuals with and without multiple health conditions during home quarantine in India due to the COVID-19 pandemic: a cross-sectional studyby Ramesh Chandra Patra on 6 Febbraio 2025
CONCLUSION: Our findings indicate that individuals with chronic health issues exhibit higher mental health problems, lower quality of sleep and have a lower health-related QoL. More research is required and also government should plan on taking care of those patients.
- Depression, anxiety and its predictor among internally displaced person in metekel Ethiopia, 2023: using a structural equation modelby Solomon Debela Bekeko on 6 Febbraio 2025
CONCLUSION: Displacement medically confirmed mental illness, death of a loved one, and post-traumatic stress disorder (PTSD) significantly impact anxiety. Policymakers should provide greater access to mental health management and prevention services, and medical practitioners should understand the connection between depression and anxiety.
- Case report: Development of anxiety symptoms after receiving the Pfizer-BioNTech (BNT162b2) COVID-19 vaccine: a case seriesby Maris Taube on 6 Febbraio 2025
Severe acute respiratory sindrome - Coronavirus - 2 (SARS-CoV-2) (Coronavirus disease - 19 (COVID-19)) infection can result in long-term health consequences, such as long COVID. The clinical manifestations of long COVID include depression, anxiety, brain fog with cognitive dysfunction, memory issues, and fatigue. However, the links between vaccination and psychiatric disorders have been less studied. This article describes three patients who reported anxiety after receiving a complete course of...
- The Lived Experience of Adult Cancer Survivors After Hematopoietic Stem Cell Transplantation: A Qualitative Study From Saudi Arabiaby Hamdan Almutairi on 6 Febbraio 2025
CONCLUSION: Exploring the lived experiences of cancer survivors can inform supportive health care management. Patients who underwent HSCT reported a series of challenges at the physical, psychosocial, and social levels. Further quantitative research studies are recommended to confirm the impact of HSCT on the QOL of cancer survivors in the Saudi Arabian context.
- A cognitive neural circuit biotype of depression showing functional and behavioral improvement after transcranial magnetic stimulation in the B-SMART-fMRI trialby Leonardo Tozzi on 6 Febbraio 2025
We previously identified a cognitive biotype of depression characterized by treatment resistance, impaired cognitive control behavioral performance and dysfunction in the cognitive control circuit, comprising the dorsolateral prefrontal cortex (dLPFC) and dorsal anterior cingulate cortex (dACC). Therapeutic transcranial magnetic stimulation (TMS) to the left dLPFC is a promising option for individuals whose depression does not respond to pharmacotherapy. Here, 43 veterans with...
- Research Progress and Trends in Exercise Interventions for Mild Cognitive Impairment: A Bibliometric Visualization Analysis Using CiteSpaceby Qifeng Han on 6 Febbraio 2025
CONCLUSION: Research on exercise interventions for MCI has been steadily gaining attention, becoming an interdisciplinary research area in fields such as geriatrics and neuroscience, with relevant findings concentrated in specific journals. In the collaboration network, developed countries dominate, showing systematic patterns of inter-institutional collaboration, while author collaborations are primarily focused within institutions. Current research is centered on the design and mechanisms of...
- Research Hotspots and Trends in Acupuncture for Cancer:A bibliometric analysis from 2004 to 2024by Zhe Ji on 6 Febbraio 2025
CONCLUSION: The future research focus will be on acupuncture as a treatment for sleep disorders, the alleviation of radiotherapy complications and the improvement of postoperative quality of life. Research on acupuncture in the field of breast cancer is more extensive compared to other cancers. Therefore, it is necessary to strengthen research on acupuncture in different cancer types.
- Antidepressant Treatment Response Prediction With Early Assessment of Functional Near-Infrared Spectroscopy and Micro-RNAby Lok Hua Lee on 6 Febbraio 2025
While functional near-infrared spectroscopy (fNIRS) had previously been suggested for major depressive disorder (MDD) diagnosis, the clinical application to predict antidepressant treatment response (ATR) is still unclear. To address this, the aim of the current study is to investigate MDD ATR at three response levels using fNIRS and micro-ribonucleic acids (miRNAs). Our proposed algorithm includes a custom inter-subject variability reduction based on the principal component analysis (PCA). The...
- A multi-level meta-analysis of the relationship between decision-making during birth and postpartum mental healthby Louisa Arnold on 6 Febbraio 2025
CONCLUSIONS: Ineffective decision-making is a significant contributing factor to the development of adverse postpartum mental health problems outcomes. Implications for practice concern establishing numerous antenatal care contacts as a standard to enhance birth preparedness for both birthing individuals and providers. Additionally, measuring the experience of intrapartum decision-making as an indicator of quality of care as a default to monitor, analyse, and improve decision-making and to...
- Fusion Model Using Resting Neurophysiological Data to Help Mass Screening of Methamphetamine Use Disorderby Chun-Chuan Chen on 6 Febbraio 2025
Methamphetamine use disorder (MUD) is a substance use disorder. Because MUD has become more prevalent due to the COVID-19 pandemic, alternative ways to help the efficiency of mass screening of MUD are important. Previous studies used electroencephalogram (EEG), heart rate variability (HRV), and galvanic skin response (GSR) aberrations during the virtual reality (VR) induction of drug craving to accurately separate patients with MUD from the healthy controls. However, whether these abnormalities...
- Effectiveness of Extended Screening and Brief Intervention (X-SBI) on Substance Misuse and Related Outcomes in Correctional Settingsby Abhishek Ghosh on 6 Febbraio 2025
CONCLUSION: Integrating three-session X-SBI into CS may effectively address substance misuse.
- On the fence: Factors associated with COVID-19 vaccine hesitancy among sexually Minoritized men who use substances in the United Statesby Renessa S Williams on 6 Febbraio 2025
CONCLUSION: The lower vaccination rates among those with a negative HIV status and those who use methamphetamine and opioids warrant attention to inform future vaccination efforts.
- Potential improvement in spatial accessibility of methadone treatment with integration into other outpatient substance use disorder treatment programs, New York City, 2024by Marcus A Bachhuber on 5 Febbraio 2025
CONCLUSION: Efforts to increase access to methadone treatment in the US should promote expansion to additional non-OTP outpatient SUD treatment programs. Such integration is anticipated to increase spatial accessibility of methadone treatment substantially, greatly enhancing the potential for patient access.
- Exploring the Impact of COVID-19 on a Child Maltreatment Prevention Networkby Patricia L Kohl on 5 Febbraio 2025
CONCLUSIONS: Disruptions during COVID-19 coincided with fewer connections among organizations. Collaborative members had higher odds of connection before and during COVID-19, suggesting a potential strategy for building and maintaining a cross-sector service network. Understanding network structure and change in the early stages of COVID-19 provides an opportunity to work on building and sustaining inter-organizational connections essential in violence prevention and child well-being and other...
- Influence of Risk Factor Combinations on Incidence Rates of SUDEP: A Population-Based Studyby Torbjörn Tomson on 5 Febbraio 2025
BACKGROUND AND OBJECTIVE: Information on absolute risks of sudden unexpected death in epilepsy (SUDEP) in individual patients with epilepsy is scarce. Our main objective was therefore to explore the range in incidence rates of SUDEP to provide a more solid basis for individualized counseling and to characterize patients with high and very high SUDEP incidence for future intervention studies aiming at prevention of SUDEP.
- On the fence: Factors associated with COVID-19 vaccine hesitancy among sexually Minoritized men who use substances in the United Statesby Renessa S Williams on 6 Febbraio 2025
CONCLUSION: The lower vaccination rates among those with a negative HIV status and those who use methamphetamine and opioids warrant attention to inform future vaccination efforts.
- Electrophysiological properties of melanin-concentrating hormone neuron subpopulations defined by anatomical localization and CART expressionby Rafiat Damilola Adekunle on 6 Febbraio 2025
INTRODUCTION: Melanin-concentrating hormone (MCH) neurons are essential regulators of energy and glucose homeostasis, sleep-wake behaviors, motivation, learning and memory. These neurons are anatomically distributed across the medial (MH) and lateral hypothalamus (LH), and the adjacent zona incerta (ZI), which may represent functional subgroups with distinct connectivity with different brain regions. Furthermore, MCH neurons can be classified according to co-expression of neuropeptides, such as...
- Nicotinic alpha7 receptors on cholinergic neurons in the striatum mediate cocaine-reinforcement, but not food rewardby Michael Fritz on 5 Febbraio 2025
The neurotransmitter acetylcholine has since long been implicated in reward learning and drug addiction. However, the role of specific cholinergic receptor subtypes on different neuronal populations remain elusive. Here, we studied the function of nicotinic acetylcholinergic alpha 7 receptors (α7 nAChRs) in cocaine and food-enforced behaviors. We found that global deletion of α7 nAChRs in mice attenuates cocaine seeking in a Pavlovian conditioned place preference paradigm and decreases operant...
- A humanized monoclonal antibody attenuates fentanyl self-administration and reverses and prevents fentanyl-induced ventilatory depression in rhesus monkeysby Lindsey K Galbo-Thomma on 5 Febbraio 2025
Medications for opioid use disorder (OUD) and overdose have been available for decades, yet nearly 70% of fatal drug overdoses in the United States are attributed to the opioid receptor agonist fentanyl and its analogs. There is a pressing need for more and better medications that reduce fentanyl use and prevent overdose. A humanized (h) monoclonal antibody (mAb) targeting fentanyl, hHY6-F9, was tested for attenuating intravenous fentanyl self-administration and reversing and preventing...
- Clinical and public health challenges of crack consumptionby Tiphaine Robet on 5 Febbraio 2025
Crack, the freebase form of cocaine, offers faster and more intense psychoactive effects due to its mode of administration by inhalation, while being of lower cost. These molecules act by blocking the reuptake of monoaminergic neurotransmitters, and their main effects stem from the rapid adrenergic response. The psychoactive effect is characterized by a marked surge of energy and social disinhibition. Crack consumption exacerbates the vulnerabilities of marginalized populations, requiring new...
- A New Insight into the Role of CART Peptide in Serotonergic Function and Anxietyby Nagalakshmi Balasubramanian on 5 Febbraio 2025
Cocaine- and amphetamine-regulated transcript (CART) peptide has been implicated in stress-related behaviors that are regulated by central serotonergic (5-HT) systems in the dorsal raphe nucleus (DRN). Here, we aimed to investigate the interaction between CART and DRN 5-HTergic systems after initially observing CART axonal terminals in the DRN. We found that microinfusion of CART peptide ((55-102)) into the DRN-induced anxiogenic effects in male C57BL/6J mice, while central administration of...
- Risk analysis approaches for microbial ingredients in microbial-based cleaning productsby Diane Boesenberg on 6 Febbraio 2025
Microbial-based cleaning products (MBCPs) are an emerging class of cleaning products that contain viable microorganisms, often bacteria or bacterial endospores, as intentionally added formulation ingredients for cleaning and/or odor control. Although several well-established methodologies exist to support risk analysis for conventional chemical-based cleaning products, at present there are no widely recognized methods or commonly utilized frameworks to support risk analysis for use of microbial...
- Exploring Perspectives Towards the Gambling Industry and Its Marketing Strategies Among Young People in Western Australiaby Brooklyn Royce on 6 Febbraio 2025
CONCLUSION: This research provides further evidence about young people's everyday exposure to gambling and the need for comprehensive approaches to protect them from industry marketing. SO WHAT?: Findings reinforce the ubiquity of young people's exposure to gambling and the highly engaging and sophisticated tactics used by industry to engage young people in their harmful products. Researchers, advocates, practitioners and policymakers can use these findings to further advocate for increased...
- Mapping corporate sponsorship of alcohol and gambling associations: An Australian pilot studyby Cara Platts on 5 Febbraio 2025
CONCLUSIONS: In Australia, many alcohol and gambling industry associations do not disclose their members or corporate partners and provide limited funding information. Members and corporate partners of Australian alcohol and gambling industry associations rarely disclose their support and are diverse in focus, size, members, partners, purpose and activities.
- Inaugural Editorial: Curating the Catalog of Knowledge About Gambling and Gambling Problemsby James P Whelan on 5 Febbraio 2025
No abstract
- Investigating behavioural addictions in adults with and without attention deficit hyperactivity disorderby James L Findon on 5 Febbraio 2025
Attention deficit hyperactivity disorder (ADHD) confers greater risk of alcohol and substance use disorders, which may be linked to altered compulsivity and impulsivity within the condition. However, no study has investigated the link between these constructs and behavioural addictions in ADHD. The aim of this study was to investigate whether individuals with ADHD show increased impulsivity, compulsivity, and associated distress, as well as addictive behaviour for gambling, exercise, and...
- Gambling in Connecticut adolescents: Prevalence, socio-demographic characteristics, trauma exposure, suicidality, and other risk behaviorsby Elina A Stefanovics on 5 Febbraio 2025
Adolescent gambling is a public health concern and has been linked to suicidality, various risk behaviors, and poor health outcomes. However, there is a limited understanding of specific risk and protective factors that may influence gambling behavior in Connecticut adolescents, especially in changing gambling environments. This study examines relationships between adolescents reporting gambling in the past-year and a range of health risk behaviors including vaping, traumatic experiences,...
- Pre-Season Energy Deficiency Predicts Poorer Performance During a Competitive Season in Collegiate Female Long-Distance Runnersby Emily Ann Lundstrom on 6 Febbraio 2025
Female distance runners are at a high risk for chronic energy deficiency (ED). ED during predominantly high-volume and/or high-intensity training phases may compromise performance. The relationship between pre-season energy status and running performance in female runners across a season is unclear. To test if energy status as defined by resting metabolic rate ratio (RMR(ratio)) is associated with running performance, female collegiate distance runners (18-25 yr; n = 38) were assessed across...
- Exploring the Extent and Nature of Disordered Eating Among Canadian Adolescents and Young Adults With Spina Bifida and Hydrocephalusby Revi Bonder on 6 Febbraio 2025
CONCLUSION: Our work underscores the urgency for further research that focuses on assessing eating disorders/disordered eating behaviours in AYA with SBH.
- Can invasive interventions be avoided with a holistic swallowing therapy program in older patients in intensive care units: percutaneous endoscopic gastrostomy tubes or oral intake?by Çağla Eliküçük on 6 Febbraio 2025
INTRODUCTION: The use of percutaneous endoscopic gastrostomy (PEG) tubes in older patients did not show any benefits in terms of survival, improvement in quality of life, or reduction in aspiration pneumonia. Significant gaps exist regarding the evidence for the evaluation and management of dysphagia in older patients. This study aimed to diagnose swallowing disorders and highlight the importance of swallowing therapy in older patients in intensive care units (ICUs).
- Patient experiences of internet-based enhanced cognitive behavior therapy for eating disordersby Anne-Charlotte Wiberg on 6 Febbraio 2025
CONCLUSIONS: The study highlighted considerations for designing and implementing ICBT-E, including tailoring content to diverse patient symptoms, managing time demands, and considering motivation and self-discipline when assigning this treatment. While ICBT-E shows promise for the widespread dissemination of treatment for EDs, ongoing evaluation of progress during treatment and timely referral to alternative interventions for non-responders are crucial for optimizing outcomes.
- Empirically Determining Binge/Purge Frequency Thresholds for Differentiating Anorexia Nervosa-Restricting Subtype vs. Binge-Purge Subtypeby Sophie R Abber on 6 Febbraio 2025
CONCLUSIONS: Findings suggest that one binge eating and/or purge episode in the past month provides adequate distinction between subtypes. These findings indicate that the DSM's definition of AN-BP may need to be revised to specify that the presence of any binge eating or purging, rather than "recurrent" binge eating or purging, is sufficient for subtyping AN.
- Zinc levels in severe eating disordersby Kara Leach on 5 Febbraio 2025
CONCLUSIONS: Given zinc's pervasive roles in metabolism throughout the body as well as common symptoms of deficiency including impaired taste and smell, decreased appetite, and depression, zinc levels could be relevant to the high relapse rate in severe ED. The observed decrease in zinc, which was larger in cases than controls, during refeeding suggests the possibility of a "refeeding hypozincemia" which may present a new therapeutic target. These characteristics make zinc an intriguing focus of...
- What works for whom in pediatric OCD: description of causally interpretable meta-analysis methods and report on trial data harmonizationby Lesley A Norris on 6 Febbraio 2025
CONCLUSIONS: Applying CI-MA to harmonize data has the potential to answer "what works for whom?" in pediatric OCD.
- Brexpiprazole augmentation in treatment-resistant obsessive-compulsive disorder: a preliminary retrospective observational studyby Luca Giacovelli on 5 Febbraio 2025
Obsessive-compulsive disorder (OCD) is a chronic illness associated with significant functional impairment. Monotherapy with serotonin reuptake inhibitors (SRIs) often leads to only partial improvement of symptoms. In such cases, a common, well established, treatment approach for most patients is the augmentation of SRI therapy with antipsychotic medications. Brexpiprazole is an atypical antipsychotic agent that acts as a partial agonist of 5-HT1A, D2, and D3 receptors. Purpose of this...
- Altered controllability of functional brain networks in obsessive-compulsive disorderby Ya Tian on 5 Febbraio 2025
Disruptions in the dynamic transitions between brain states have been implicated in cognitive, emotional, and behavioral dysregulations across various mental disorders. However, the irregularities in dynamic brain state transitions associated with obsessive-compulsive disorder (OCD) remain unclear. The present study included 99 patients with OCD and 104 matched healthy controls (HCs) to investigate alterations in dynamic brain state transitions by using network control theory. Functional...
- UK medical students' mental health and their intention to drop out: a longitudinal studyby Asta Medisauskaite on 5 Febbraio 2025
CONCLUSIONS: A substantial number of UK medical students experienced mental ill-health symptoms, about one in five medical students considers leaving medical school, and mental ill-health symptoms contributed to students' intentions to leave their medical education. Medical schools should improve the learning environment for students and encourage them to seek help to reduce the stigma of mental ill-health symptoms (eg, through education, signposting). It may be useful for medical schools to...
- Phenome-wide association studies between SERINC2 and neuropsychiatric disordersby Ping Liu on 4 Febbraio 2025
CONCLUSION: SERINC2 is primarily linked to substance use disorders, schizophrenia, OCD, autism and bipolar disorder, not only statistically but also biologically.
- Chronic Pain and Obsessive-Compulsive Disorder: A Scoping Reviewby Chad Sloley on 4 Febbraio 2025
CONCLUSION: While there has been considerable and growing research in the fields of both OCD and CP over the years, focused research into their potential association has been limited and potentially overlooked. The results of this review, however, suggest a complex relationship between CP and OCD. Prevalence rates between the two conditions vary widely across different populations, although the underlying reason for this remains unclear at this stage. There are commonalities in terms of...
- Pre-disaster Health Vulnerabilities Predict Major Depressive Disorder Symptoms Among High-Risk Puerto Rican Adults after Hurricanes Maria and Irmaby Regina M Musicaro on 6 Febbraio 2025
CONCLUSIONS: Research is needed to understand other pathways through which pre-disaster health conditions predict post-disaster mental health.
- Depression, anxiety and its predictor among internally displaced person in metekel Ethiopia, 2023: using a structural equation modelby Solomon Debela Bekeko on 6 Febbraio 2025
CONCLUSION: Displacement medically confirmed mental illness, death of a loved one, and post-traumatic stress disorder (PTSD) significantly impact anxiety. Policymakers should provide greater access to mental health management and prevention services, and medical practitioners should understand the connection between depression and anxiety.
- A cognitive neural circuit biotype of depression showing functional and behavioral improvement after transcranial magnetic stimulation in the B-SMART-fMRI trialby Leonardo Tozzi on 6 Febbraio 2025
We previously identified a cognitive biotype of depression characterized by treatment resistance, impaired cognitive control behavioral performance and dysfunction in the cognitive control circuit, comprising the dorsolateral prefrontal cortex (dLPFC) and dorsal anterior cingulate cortex (dACC). Therapeutic transcranial magnetic stimulation (TMS) to the left dLPFC is a promising option for individuals whose depression does not respond to pharmacotherapy. Here, 43 veterans with...
- Potentially traumatic childbirth experience, childbirth-related post-traumatic stress disorder symptoms, and the parent-infant relationship in non-birthing parentsby Rebecca Hunter on 5 Febbraio 2025
CONCLUSIONS: This study's sample revealed a substantial proportion of non-birthing parents experiencing birth as potentially traumatic, with 10.1% meeting CB-PTSD criteria, a higher incidence than previously reported in the literature. This may be attributed the implications of the COVID-19 pandemic. CB-PTSD symptoms were negatively associated with feelings of invasion in the parent-infant relationship, but not with warmth. Future research should aim to replicate this study design with routine...
- Bisexual+ Women and Gender Nonbinary Survivors of Sexual Violence: Comparisons of Substance Use, PTSD Symptoms, and In-Person Social Reactions to Sexual Violence Disclosureby Gabriela López on 5 Febbraio 2025
The current study examined whether in-person social reactions to disclosure of sexual violence vary as a function of sexual identity (heterosexual vs. bisexual+ survivors) and gender (women vs. nonbinary survivors). A secondary aim of the current study was to examine whether sexual identity and/or gender moderated the relation between social reactions to disclosure and various negative psychological/behavioral outcomes. (i.e. symptoms of posttraumatic stress disorder (PTSD), heavy episodic...
- Relationships Among PTSD, Trait Mindfulness, and Factors of SUD in Veterans Enrolled in Specialty SUD Treatmentby Kristoffer Rehder on 5 Febbraio 2025
CONCLUSIONS: Facets of observe, non-judging, and non-reactivity may help explain relationships between PTSD and SUD-related factors. However, associations with non-judging and observe were in the opposite direction hypothesized. More research is needed to understand positive associations between mindfulness and factors of SUD in veteran samples.
- Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agentsby Fernanda M Q Silva on 5 Ottobre 2024
Fibromyalgia syndrome (FMS) is a chronic disorder characterized commonly by widespread musculoskeletal pain and fatigue, predominantly affecting women, with its complexity often leading to underdiagnosis and complicating treatment effectiveness. Transcranial magnetic stimulation (TMS) metrics are potential markers to optimize FMS treatments; however, evidence is limited. Our study aimed to explore the relationship between cortical excitability and inhibition, assessed through TMS markers, and...
- The Impact of Obesity as a Peripheral Disruptor of Brain Inhibitory Mechanisms in Fibromyalgia: A Cross-Sectional Studyby Walter Fabris-Moraes on 13 Luglio 2024
Background/Objective: Obesity, characterized by chronic inflammation, may serve as a surrogate marker for more dysfunctional peripheral inflammation, potentially exacerbating FM symptomatology. Given this premise, this study aimed to investigate the effects of obesity as an effect modifier on neural and clinical variables, specifically those indexing pain-compensatory mechanisms in FM symptoms. Methods: A cross-sectional study was conducted with 108 participants who underwent a standardized TMS...
- No add-on therapeutic benefit of at-home anodal tDCS of the primary motor cortex to mindfulness meditation in patients with fibromyalgiaby Perianen Ramasawmy on 20 Giugno 2024
CONCLUSIONS: Our findings demonstrate no synergistic or add-on efffect of anodal tDCS of the left M1 compared to the proper effect of MM in patients with fibromyalgia.
- Exercise effects on cortical excitability in pain populations: A systematic review and meta-analysisby Danielle Carolina Pimenta on 11 Giugno 2024
CONCLUSIONS: These findings suggest that exercise interventions positively affect pain relief by modifying corticospinal excitability, but their effects on ICI/ICF are still unclear. While the results are inconclusive, they provide a basis for further exploration in this area of research; future studies should focus on establishing standardized TMS measurements and exercise protocols to ensure consistent and reliable findings. A large-scale RCT that examines various exercise interventions and...
- Effect of neuronavigated repetitive Transcranial Magnetic Stimulation on pain, cognition and cortical excitability in fibromyalgia syndromeby Vikas Kumar Tiwari on 25 Gennaio 2024
CONCLUSIONS: Findings suggest that repetitive transcranial magnetic stimulation intervention is effective in managing pain alongside cognition and sleep disturbances in patients of fibromyalgia. It may prove to be an important tool in relieving fibromyalgia-associated morbidity.
- TMS in combination with a pain directed intervention for the treatment of fibromyalgia - A randomized, double-blind, sham-controlled trialby Einat Tilbor on 27 Dicembre 2023
CONCLUSION: Our results suggest that a course of dTMS combined with a pain-directed psychotherapeutic intervention can alleviate pain symptoms in FMS patients. Beyond clinical possibilities, future studies are needed to substantiate the innovative hypothesis that it is not dTMS alone, but rather dTMS-induced plasticity of pain-related networks, that enables the efficacy of pain-directed psychotherapeutic interventions.
- A cognitive neural circuit biotype of depression showing functional and behavioral improvement after transcranial magnetic stimulation in the B-SMART-fMRI trialby Leonardo Tozzi on 6 Febbraio 2025
We previously identified a cognitive biotype of depression characterized by treatment resistance, impaired cognitive control behavioral performance and dysfunction in the cognitive control circuit, comprising the dorsolateral prefrontal cortex (dLPFC) and dorsal anterior cingulate cortex (dACC). Therapeutic transcranial magnetic stimulation (TMS) to the left dLPFC is a promising option for individuals whose depression does not respond to pharmacotherapy. Here, 43 veterans with...
- Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer's disease, Alzheimer's disease-related dementias, and other cognitive disorders: a systematic review and meta-analysisby Sandeep R Pagali on 2 Febbraio 2025
CONCLUSION: The reviewed studies provide favorable evidence of improved cognition with TMS across all groups with cognitive impairment. TMS was safe and well tolerated with infrequent serious adverse events.
- Adaptive spatiotemporal encoding network for cognitive assessment using resting state EEGby Jingnan Sun on 23 Dicembre 2024
Cognitive impairment, marked by neurodegenerative damage, leads to diminished cognitive function decline. Accurate cognitive assessment is crucial for early detection and progress evaluation, yet current methods in clinical practice lack objectivity, precision, and convenience. This study included 743 participants, including healthy individuals, mild cognitive impairment (MCI), and dementia patients, with collected resting-state EEG data and cognitive scale scores. An adaptive spatiotemporal...
- Neurobiology, psychotherapeutic interventions, and emerging therapies in addiction: a systematic reviewby Christopher Lomas on 18 Dicembre 2024
Substance use disorders (SUDs) represent a major challenge in psychiatric treatment, with significant relapse rates despite various psychotherapeutic interventions. This systematic review explores the neurobiological underpinnings of addiction and examines the efficacy of psychotherapies, such as Cognitive Behavioral Therapy (CBT), Eye Movement Desensitization and Reprocessing (EMDR), Mindfulness-Based Relapse Prevention (MBRP), and emerging therapies in treating SUDs. Additionally, the study...
- Utilizing Centromedian Thalamus Connectivity to Personalize Noninvasive Neuromodulation Targetsby Cong Fu on 9 Dicembre 2024
CONCLUSIONS: The left PSMC exhibited reproducible FC with the left CM. The individual peak FC location in the left PSMC could be used as a TMS target for indirect modulation of CM activity and aid in the treatment of CM-related neurological disorders.
- Relationships between clinical symptoms, cognitive functioning, and TMS-evoked potential features in patients with major depressive disorderby Jiaxin Li on 16 Novembre 2024
CONCLUSION: The results of this study indicate that cortical dysfunction and cognitive impairment are present in patients with MDD and that there is a strong correlation between them, suggesting that TEPs detected by the TMS-EEG may be used as a biomarker for MDD patients and their cognitive impairment.
- Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Studyby Ruijie Zhang on 6 Febbraio 2025
CONCLUSIONS: Elevated folate levels correlate with morning-type preferences ("morning birds"), while higher concentrations of vitamin B6 are associated with evening-type preferences ("evening owls").
- Sleep quality during pregnancy following assisted reproductive technology and natural conceiving: a prospective birth cohort studyby Yidong Xie on 6 Febbraio 2025
CONCLUSION: The study reveals that women receiving IVF/ICSI treatment are at a higher risk of experiencing sleep disturbances throughout their pregnancy compared with women with natural conception. While partners typically do not report major sleep problems, they do exhibit increased anxiety levels. These findings underscore the necessity for screening and addressing sleep issues in women pregnant through assisted IVF/ICSI treatment, to promote their well-being during this critical period.
- Dietary Magnesium Intake Is Associated With Self-Reported Short Sleep Duration but Not Self-Reported Sleep Disorderby Shuhua Zhao on 6 Febbraio 2025
CONCLUSIONS: Dietary Mg intake is independently associated with self-reported short sleep duration but not with self-reported sleep disorders. Mg supplementation is not associated with either self-reported sleep duration or sleep disorders.
- Research Hotspots and Trends in Acupuncture for Cancer:A bibliometric analysis from 2004 to 2024by Zhe Ji on 6 Febbraio 2025
CONCLUSION: The future research focus will be on acupuncture as a treatment for sleep disorders, the alleviation of radiotherapy complications and the improvement of postoperative quality of life. Research on acupuncture in the field of breast cancer is more extensive compared to other cancers. Therefore, it is necessary to strengthen research on acupuncture in different cancer types.
- Insufficient Evidence to Recommend Shu Mian Capsule in Managing Depression With or Without Comorbid Insomnia: A Systematic Review With Meta-Analysis and Trial Sequential Analysisby Fei-Yi Zhao on 6 Febbraio 2025
CONCLUSION: The effectiveness of SMC as an alternative to conventional antidepressive treatment is unclear. For depressed patients with comorbid insomnia, adding SMC to standard care demonstrates augmented efficacy and improved safety, though the supporting evidence is methodologically limited. Further rigorous trials are warranted to confirm SMC's short-term efficacy and explore its medium- to long-term effects as either an alternative or complementary therapy. Current evidence precludes...
- Community prevalence of positional obstructive sleep apneaby Brett L Duce on 6 Febbraio 2025
CONCLUSIONS: In the SHHS population the prevalence of POSA is greater than non-POSA. The spOSA subtype is more prevalent and appears to have worse health consequences than siOSA.
- The Near Point of Convergence in Patients with Vestibular Migraineby Francisco Carlos Zuma E Maia on 6 Febbraio 2025
Introduction Vestibular migraine (VM) is one of the most common vestibular disorders and its diagnosis is based entirely on clinical features. A recent case series suggested a possible link between migraines and convergence insufficiency. Objective To compare the near point of convergence (NPC) in patients with and without VM. Methods We retrospectively reviewed the data of 50 patients with and 50 without VM, comparing the NPC between both groups. The NPC was measured according to the...
- Evaluation of zonulin levels in patients with migraineby Gözde Ülfer on 5 Febbraio 2025
CONCLUSIONS: Elevated zonulin levels in patients with migraine support the disruption of the intestinal barrier and neuroinflammation in these patients. The zonulin level may be a predictive biomarker of migraine. Multicenter, randomized trials are needed to evaluate treatments for intestinal permeability and zonulin levels in migraine patients.
- Intracranial pressure monitoring in patients with spontaneous onset of orthostatic headacheby Linda D'Antona on 5 Febbraio 2025
CONCLUSIONS: When appropriately selected, patients with a clinical picture highly suggestive of SIH, who have a negative diagnostic work-up, may benefit from consideration of invasive ICP monitoring. Moreover, a significant minority of patients with orthostatic headache may paradoxically have a high CSF pressure state, which can be detected using ICP monitoring.
- Molecular assessment of NMDAR subunits and neuronal apoptosis in the trigeminal ganglion in a model of male migraine-induced rats following Moringa oleifera alcoholic extract administrationby Ahmad Vafaeian on 5 Febbraio 2025
CONCLUSIONS: Moringa oleifera extract appears to mitigate symptoms of migraine by inhibiting apoptosis, suggesting potential efficacy in migraine treatment; however, additional research investigating a wider range of pathways is necessary.
- Pharmacokinetics of a Novel Piperaquine Dispersible Granules Formulation Under Fasting and Various Fed Conditions Versus Piperaquine Tablets When Fasted in Healthy Tanzanian Adults: A Randomized, Phase I Studyby Florence A Milando on 5 Febbraio 2025
Piperaquine tetraphosphate (PQP), a long-acting antimalarial, is being considered in a combination for chemoprevention. Dihydroartemisinin-piperaquine tablets (hard and dispersible) approved for the treatment of acute uncomplicated malaria should be administered in a fasted state, as PQP bioavailability increases with food. A new taste-masked dispersible granules PQP formulation aims to minimize the impact of food on drug exposure. This randomized, open label, parallel group, Phase I pilot study...
- Development and validation of a diagnostic model for migraine without aura in inpatientsby Zhu-Hong Chen on 5 Febbraio 2025
CONCLUSION: The predictive model developed and validated in this study demonstrates significant efficacy in identifying MWoA. Our findings highlight PFO as a potential key risk factor, underscoring its importance for early prevention, screening, and diagnosis of MWoA.
- Pre-Season Energy Deficiency Predicts Poorer Performance During a Competitive Season in Collegiate Female Long-Distance Runnersby Emily Ann Lundstrom on 6 Febbraio 2025
Female distance runners are at a high risk for chronic energy deficiency (ED). ED during predominantly high-volume and/or high-intensity training phases may compromise performance. The relationship between pre-season energy status and running performance in female runners across a season is unclear. To test if energy status as defined by resting metabolic rate ratio (RMR(ratio)) is associated with running performance, female collegiate distance runners (18-25 yr; n = 38) were assessed across...
- Exploring the Extent and Nature of Disordered Eating Among Canadian Adolescents and Young Adults With Spina Bifida and Hydrocephalusby Revi Bonder on 6 Febbraio 2025
CONCLUSION: Our work underscores the urgency for further research that focuses on assessing eating disorders/disordered eating behaviours in AYA with SBH.
- Can invasive interventions be avoided with a holistic swallowing therapy program in older patients in intensive care units: percutaneous endoscopic gastrostomy tubes or oral intake?by Çağla Eliküçük on 6 Febbraio 2025
INTRODUCTION: The use of percutaneous endoscopic gastrostomy (PEG) tubes in older patients did not show any benefits in terms of survival, improvement in quality of life, or reduction in aspiration pneumonia. Significant gaps exist regarding the evidence for the evaluation and management of dysphagia in older patients. This study aimed to diagnose swallowing disorders and highlight the importance of swallowing therapy in older patients in intensive care units (ICUs).
- Patient experiences of internet-based enhanced cognitive behavior therapy for eating disordersby Anne-Charlotte Wiberg on 6 Febbraio 2025
CONCLUSIONS: The study highlighted considerations for designing and implementing ICBT-E, including tailoring content to diverse patient symptoms, managing time demands, and considering motivation and self-discipline when assigning this treatment. While ICBT-E shows promise for the widespread dissemination of treatment for EDs, ongoing evaluation of progress during treatment and timely referral to alternative interventions for non-responders are crucial for optimizing outcomes.
- Empirically Determining Binge/Purge Frequency Thresholds for Differentiating Anorexia Nervosa-Restricting Subtype vs. Binge-Purge Subtypeby Sophie R Abber on 6 Febbraio 2025
CONCLUSIONS: Findings suggest that one binge eating and/or purge episode in the past month provides adequate distinction between subtypes. These findings indicate that the DSM's definition of AN-BP may need to be revised to specify that the presence of any binge eating or purging, rather than "recurrent" binge eating or purging, is sufficient for subtyping AN.
- Zinc levels in severe eating disordersby Kara Leach on 5 Febbraio 2025
CONCLUSIONS: Given zinc's pervasive roles in metabolism throughout the body as well as common symptoms of deficiency including impaired taste and smell, decreased appetite, and depression, zinc levels could be relevant to the high relapse rate in severe ED. The observed decrease in zinc, which was larger in cases than controls, during refeeding suggests the possibility of a "refeeding hypozincemia" which may present a new therapeutic target. These characteristics make zinc an intriguing focus of...
- Effectiveness of Group Cognitive Behavioral Therapy on Quality of Life and Psychological Wellbeing of Patients With Parkinson Disease: A Randomized Controlled Trialby Jale Narimisaei on 6 Febbraio 2025
This study investigates the impact of group cognitive behavioral therapy (CBT) on depression reduction and quality of life improvement among individuals with Parkinson disease. A randomized clinical trial with pretest and posttest measurements involved 90 participants referred to Roozbeh Hospital in Tehran in 2023, who were randomly assigned to either an experimental group (n = 45) or a control group (n = 45). The experimental group underwent a 3-month CBT intervention comprising 12 sessions of...
- Vitamin C and Gallic Acid Ameliorate Motor Dysfunction, Cognitive Deficits, and Brain Oxidative Stress in a Valproic Acid-Induced Model of Autismby Parnia Tarahomi on 6 Febbraio 2025
CONCLUSIONS: Vit C and GA could potentially alleviate anxiety-like behaviors, motor and cognitive deficits, and brain oxidative stress markers in a prenatal rat autism model. This underscores their viability as potential pharmacological interventions for treating autistic dysfunction.
- Effects of whole-head 810 nm near-infrared therapy on cognitive and neuropsychiatric symptoms in Alzheimer's disease: A pilot studyby Rong Guo on 6 Febbraio 2025
CONCLUSIONS: Whole-head 810 nm NIR light is safe and offers promising benefits for AD patients. To fully confirm its efficacy, durability, and underlying mechanisms, further large-scale randomized controlled trials are necessary.
- Patient experiences of internet-based enhanced cognitive behavior therapy for eating disordersby Anne-Charlotte Wiberg on 6 Febbraio 2025
CONCLUSIONS: The study highlighted considerations for designing and implementing ICBT-E, including tailoring content to diverse patient symptoms, managing time demands, and considering motivation and self-discipline when assigning this treatment. While ICBT-E shows promise for the widespread dissemination of treatment for EDs, ongoing evaluation of progress during treatment and timely referral to alternative interventions for non-responders are crucial for optimizing outcomes.
- Protocol for a nested case-control study: identifying neuroimaging biomarkers for the progression of subclinical depression and qi-stagnation constitution to major depressive disorder in adolescentsby Jing Wang on 5 Febbraio 2025
BACKGROUND: Major depressive disorder (MDD) frequently results in suboptimal treatment outcomes and elevated recurrence rate, with patients frequently engaging in self-harm and suicidal behavior, thereby placing a heavy burden on families and society. Specifically, MDD in adolescents is linked to an elevated suicide risk. Thus, early identification and intervention is crucial for adolescents at high risk for developing MDD. Subclinical depression (SD), characterized by depressive symptoms that...
- Effectiveness of Attentional Bias Modification Combined With Cognitive Behavioral Therapy in Reducing Relapse Risk and Cravings in Male Patients With Alcohol Use Disorder: A Quasi-Randomized Controlled Trialby Yoshifumi Amano on 5 Febbraio 2025
CONCLUSIONS: Although the combined ABM and CBT intervention did not result in statistically significant reductions in relapse risk and cravings compared to CBT alone, the overall reduction in these outcomes in both groups highlights the effectiveness of CBT in treating AUD. Future studies should use naturalistic settings and tailor the intervention to individual cognitive profiles.
- Near-infrared spectroscopy-guided personalized repetitive transcranial magnetic stimulation for bipolar depression: a case reportby Chun-Hung Chang on 4 Febbraio 2025
CONCLUSION: Our case suggests that NIRS can guide the selection of appropriate TMS protocols for patients with bipolar depression. Although our findings are promising, further randomized controlled trials are needed to validate the efficacy and safety of and determine the optimal parameters for this approach.
- Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer's disease, Alzheimer's disease-related dementias, and other cognitive disorders: a systematic review and meta-analysisby Sandeep R Pagali on 2 Febbraio 2025
CONCLUSION: The reviewed studies provide favorable evidence of improved cognition with TMS across all groups with cognitive impairment. TMS was safe and well tolerated with infrequent serious adverse events.
- Spaced Transcranial Direct Current Stimulation for Major Depressionby Maxime Couture on 29 Gennaio 2025
CONCLUSIONS: The protocol was feasible, safe, and well-tolerated and led to significant reductions in depressive symptoms. These results will need to be validated in a sham-controlled randomized trial. The inclusion of neurophysiological measures in future trials for purposes of biological target engagement might also contribute to our understanding of underlying mechanisms and biomarker discovery.
- Effects of Low-Intensity Transcranial Magnetic Stimulation in Neuropsychological Development of Pediatric Subjects With Autism Spectrum Disorder: A Longitudinal Retrospective Approachby Thonny Augusto Espinosa Mendoza on 29 Gennaio 2025
CONCLUSIONS: Both variants of TMS, Hi-TMS and Li-TMS, have proven to be promising treatments for subjects with ASD, improving social and cognitive abilities. This investigation suggests that the combination of conventional therapies and 16 sessions of Li-TMS as a treatment for individuals with ASD had significant clinical progress, specifically in maturation development according to BDI. In addition, the use of low-intensity magnetic fields may allow for safer pulse delivery in pediatric...
- Efficacy and Safety of Transcranial Magnetic Stimulation for Attention-Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysisby Binbin Fu on 20 Gennaio 2025
CONCLUSION: TMS significantly improved the inattention, hyperactivity/impulsivity, and total symptom scores in ADHD patients with minor adverse events. Future research should focus on the association between different brain regions and symptoms in ADHD patients, which is crucial for stimulation navigation in TMS interventions. The trial is registered in PROSPERO (PROSPERO registry number: CRD42023473853).
- Efficacy of transcranial magnetic stimulation in anorexia nervosa: a systematic review and meta-analysisby Amir Reza Bahadori on 15 Gennaio 2025
CONCLUSION: TMS represents an effective therapy for patients with AN, leading to improvements in both BMI and core symptoms of AN, with minor and transient side effects.