AGGIORNAMENTO SCIENTIFICO IN TEMPO REALE FORNITO DA:
- Evaluating Alzheimer's disease with the TMS-EEG perturbation complexity indexby Brenna Hagan on 23 Gennaio 2026
The Perturbation Complexity Index-State Transitions (PCI^(ST)) measures the complexity of the brain's response to transcranial magnetic stimulation (TMS) using electroencephalography (EEG) and is sensitive to consciousness, such as minimally conscious states. Individuals with early-stage Alzheimer's disease (AD) show dysfunction of conscious processes, such as attention, working memory, episodic memory, and executive function, with relatively spared unconscious processes, such as procedural...
- The Accuracy of the PREP2 Prediction Tool for Upper Limb Outcomes After Stroke as Part of Routine Clinical Careby Harry Jordan on 23 Gennaio 2026
BackgroundThe Predict REcovery Potential-2 (PREP2) prediction tool uses clinical assessments and transcranial magnetic stimulation (TMS) within 1 week post-stroke to predict individuals' upper limb functional outcome at 3 months (3M) post-stroke. PREP2 was successfully implemented in clinical care at Auckland City Hospital, New Zealand in 2017.ObjectiveThe primary aim was to evaluate the accuracy of PREP2 predictions made by clinicians during routine clinical care, with a threshold of 70%...
- A Watershed Algorithm GUI for Personalized fMRI-guided rTMS Targetby Zi-Jian Feng on 22 Gennaio 2026
Personalized repetitive transcranial magnetic stimulation (rTMS) increasingly relies on resting-state functional magnetic resonance imaging (fMRI) to select stimulation sites, yet most pipelines depend on user-defined thresholds and atlas masks, which can shift individualized targets. We propose a watershed-based approach, implemented in a graphical user interface, that performs threshold-independent segmentation of functional images to support rTMS target localization. As a proof-of-concept, we...
- Causal connectivity maps derived from single-pulse interleaved TMS/fMRIby Lison Bossus on 22 Gennaio 2026
Understanding causal interactions between cortical and subcortical brain regions is critical for mapping human functional connectivity. While non-invasive methods such as fMRI and diffusion imaging have provided valuable insights into brain connectivity, these approaches remain correlational and cannot establish causal circuit mechanisms. Here, we aimed to generate reliable causal connectivity maps using interleaved single-pulse transcranial magnetic stimulation with functional MRI (spTMS/fMRI)....
- "Tapping" into neural inhibition in focal hand dystonia: an evaluation of a finger-tapping task using TMS and fMRIby Baothy P Huynh on 19 Gennaio 2026
CONCLUSION: These findings suggest that individuals with FHD may selectively recruit cerebellar sensorimotor circuits to modulate inhibition during movement of the non-symptomatic hand, though this pattern was not observed during movement of the symptomatic hand. The cerebellum may play a central role in adaptive motor control in FHD. Future work should leverage symptom-inducing tasks and alternative inhibitory markers to further clarify these mechanisms.
- Investigating the methodological foundation of lesion network mappingby Martijn P van den Heuvel on 16 Gennaio 2026
Lesion network mapping (LNM) is a neuroimaging framework that uses normative functional connectivity (FC) data to link heterogeneous brain lesions and functional alterations to brain networks implicated in neurological and psychiatric conditions. However, many of the networks identified by LNM and related methods appear to be highly similar across diverse conditions such as addiction, depression, psychosis and epilepsy. To understand this similarity, we re-examined the data from multiple LNM...
- Comparative efficacy of microvascular decompression and radiofrequency rhizotomy in idiopathic trigeminal neuralgia with a neurovascular contact without root distortionby Juan M Altamirano on 23 Gennaio 2026
CONCLUSION: MVD resulted in superior pain control compared to RFR in patients with idiopathic TN with a neurovascular contact without root distortion and with a PSD
- Aligned piezoelectric fibrous scaffolds for prevention of traumatic neuroma formationby Yujie Chen on 23 Gennaio 2026
CONCLUSION: Aligned piezoelectric PLLA fibrous scaffolds facilitate functional nerve regeneration, promote remyelination, and attenuate neuropathic pain and inflammation. These findings suggest that such scaffolds offer a promising nanomedicine-based strategy for the prevention of traumatic neuroma following peripheral nerve injury.
- Pedunculoside attenuates the progression of neuropathic pain by affecting microglial polarization through Inhibition of the TLR4-NF-kappaB pathwayby Changjun Huang on 23 Gennaio 2026
Neuropathic pain (NP) is a common and disabling condition characterized by microglial polarization-evoked neuroinflammation. Pedunculoside has been implicated in several inflammation-related diseases and exerts the neuroprotective effects However, its role in NP remains unclear. In this study, pedunculoside dose-dependently suppressed LPS-induced activation of BV2 microglial cells by reducing expression of the microglial marker IBA-1, but without obvious cytotoxicity. Immunofluorescence assay...
- Elevated circulating cell-free mitochondrial DNA in fabry disease: insights into inflammatory activationby Yujing Yuan on 23 Gennaio 2026
CONCLUSIONS: Mitochondrial dysfunction, reflected by elevated ccf-mtDNA, is implicated in FD pathogenesis and may be linked to inflammatory activation. ccf-mtDNA represents a promising diagnostic biomarker for FD, potentially offering an additional therapeutic target when combined with ERT.
- Functional Recovery Following Spinal Cord Stimulation in a Patient Utilizing Prospera Spinal Cord Stimulation System with Multiphase Stimulationby Jamal Hasoon on 23 Gennaio 2026
Spinal cord stimulation (SCS) is an established treatment for chronic neuropathic pain, particularly in patients who have failed conservative therapy or prior spine surgery. This case highlights significant pain reduction and functional recovery in a patient with severe lumbar radiculopathy and weakness following prior lumbar surgery. A 39-year-old female with multilevel disc bulges causing spinal stenosis, and chronic lumbar radiculopathy presented with severe low back and left leg pain. She...
- Programmed intermittent paravertebral bolus infusion reduces the incidence of postoperative chronic pain three months after thoracoscopic surgery in elderly patients: an observational studyby Lu Wang on 22 Gennaio 2026
No abstract
- Validation of the Brief Resilience Scale among Romanian healthcare workersby Beatrice Adriana Balgiu on 23 Gennaio 2026
CONCLUSIONS: The psychometric properties of the BRS support its applicability for assessing resilience in Romanian healthcare workers.
- Flexible brain state engagement predicts cognitive control transdiagnosticallyby Jean Ye on 23 Gennaio 2026
Cognitive control supports adaptive responses in an ever-changing world. While alterations in cognitive control have been consistently observed in a range of psychiatric disorders, the neural mechanisms giving rise to this behavioral variation remain elusive. Here, we tested whether the ability to flexibly recruit recurring brain activation patterns (i.e., brain states) may serve as an intermediate phenotype supporting cognitive control in individuals with a spectrum of clinical symptoms. We...
- Multimedia tools in preoperative patient education: A systematic review of their role in neuraxial anesthesiaby Kimia Khonakdar on 23 Gennaio 2026
Preoperative anxiety is a major concern for patients undergoing neuraxial anesthesia, often leading to increased physiological stress and reduced satisfaction. Recently, multimedia-based education has been encouraged as a new approach to enhancing patient understanding and reducing anxiety. This paper investigates whether multimedia-based patient education improves preoperative anxiety, patient satisfaction, and hemodynamic stability in patients undergoing neuraxial anesthesia. According to...
- Unseen struggles: A qualitative exploration of mental health challenges among higher education students in Tamil Nadu, Indiaby Gajalakshmi Radhakrishnan on 23 Gennaio 2026
CONCLUSION: These findings underscore the urgent need for mental health interventions tailored to the specific needs of higher education students in Tamil Nadu. Implementing supportive policies, accessible counseling services, and targeted awareness programs within educational institutions could significantly alleviate the mental health burden. The context-specific challenges identified in this study provide valuable insights for designing effective mental health interventions across diverse...
- Differences in psychological well-being, physical activity, and perception of the value of physical education among Italian middle and high school teachers: A cross-sectional studyby Sonia Angilletta on 23 Gennaio 2026
CONCLUSION: These findings highlight the need to support female and older teachers to recognize the value of exercise and address their mental health needs/issues. Promoting physical activity among teachers can increase their psychological well-being and improve teaching effectiveness and student outcomes.
- Maternal-physiological parameters and prenatal mindfulness interventions - A scoping reviewby Prathibha Lydia Braggs on 23 Gennaio 2026
Pregnancy is a unique experience for every woman, but it is not always easy. A good health indicator in the country is reduced maternal mortality and morbidity. How mindfulness affects maternal mental health parameters such as stress, anxiety, and depression has been well documented. However, their impact on maternal physiological parameters has not been explored much, which is the primary goal of this scoping review. Three databases (PubMed, Scopus, and Embase) were searched to identify studies...
- Differences in psychological well-being, physical activity, and perception of the value of physical education among Italian middle and high school teachers: A cross-sectional studyby Sonia Angilletta on 23 Gennaio 2026
CONCLUSION: These findings highlight the need to support female and older teachers to recognize the value of exercise and address their mental health needs/issues. Promoting physical activity among teachers can increase their psychological well-being and improve teaching effectiveness and student outcomes.
- Maternal-physiological parameters and prenatal mindfulness interventions - A scoping reviewby Prathibha Lydia Braggs on 23 Gennaio 2026
Pregnancy is a unique experience for every woman, but it is not always easy. A good health indicator in the country is reduced maternal mortality and morbidity. How mindfulness affects maternal mental health parameters such as stress, anxiety, and depression has been well documented. However, their impact on maternal physiological parameters has not been explored much, which is the primary goal of this scoping review. Three databases (PubMed, Scopus, and Embase) were searched to identify studies...
- The Gut Microbiota as a Mediator in the Relationship Between Dietary Patterns and Depressionby Adrián Hernández-Cacho on 23 Gennaio 2026
The interplay between diet, gut microbiota, and depressive symptoms is increasingly recognized, but underlying mechanisms remain unclear. We investigated whether adherence to several dietary patterns relates to gut microbial signatures and whether these profiles are associated with depressive symptoms in an elderly Mediterranean cohort. In 644 participants, 16S ribosomal RNA gene sequencing and dietary intake from a food-frequency questionnaire were obtained at baseline and 1-year follow-up....
- Evaluating the efficacy of aerobic exercise as therapy for depression and anxiety in women with PCOS: a systematic reviewby Lorna Evelyn Mansell on 23 Gennaio 2026
CONCLUSION: Findings should be interpreted cautiously due to limited report numbers, methodological concerns and heterogeneity in interventions and outcome measures. While this review aimed to assess all exercise modalities, only aerobic exercise interventions were identified. These interventions appear effective in reducing depression and anxiety symptoms in women with PCOS. Future research should include psychological outcomes and explore resistance or combined diet-exercise interventions.
- Emotional regulation and mental health profiles among Chinese junior middle school students: evidence for the dual-factor modelby Jichang Guo on 23 Gennaio 2026
CONCLUSION: Three distinct profiles emerged, differing from the traditional dual-factor model. Cognitive reappraisal protects mental health, while expressive suppression correlates with poorer outcomes, highlighting the need for targeted interventions promoting cognitive reappraisal.
- Quality of life in hospitalized COVID-19 patients: the role of psychosocial, inflammatory, and dopaminergic pathwaysby M Graça Pereira on 23 Gennaio 2026
INTRODUCTION: A significant proportion of COVID-19 survivors continues to suffer from persistent physical and psychological sequelae after hospital discharge.
- Psychopathy is a neglected public health problemby Melanie A Chinchilla on 23 Gennaio 2026
Although psychopathy has been widely studied within criminal justice contexts, its impact on society is rarely considered in public health contexts. Even so, evidence strongly implicates psychopathic traits in substantial costs (not just fiscal) to society. Individuals with psychopathic features commonly hurt those with whom they have relationships in important ways, including through abuse, manipulation, deception and, often, violence. We review the empirical evidence linking psychopathic...
- Emotional Adaptation Using a Program Based on Cognitive Emotion Regulation Strategies in Patients with Substance Use Disorder: A Double-blinded Randomized Controlled Trialby Zakiye Ghelbash on 23 Gennaio 2026
CONCLUSIONS: Educational programs based on emotion regulation can play a significant role in improving emotional adaptation in patients with substance use disorder. Therefore, this educational program is suggested as a complementary psychological approach to improving the level of psychological health of patients with substance use disorder.
- Long-term relapse: markers, mechanisms, and implications for disease management in alcohol use disorderby John F Kelly on 23 Gennaio 2026
CONCLUSIONS: Findings have implications for long-term disease management during AUD recovery providing a set of potential preliminary markers and mechanisms that might be assessed, monitored, and, when necessary, intervened upon prior to the onset of heavy symptomatic alcohol use to prevent AUD recurrence.
- Unseen struggles: A qualitative exploration of mental health challenges among higher education students in Tamil Nadu, Indiaby Gajalakshmi Radhakrishnan on 23 Gennaio 2026
CONCLUSION: These findings underscore the urgent need for mental health interventions tailored to the specific needs of higher education students in Tamil Nadu. Implementing supportive policies, accessible counseling services, and targeted awareness programs within educational institutions could significantly alleviate the mental health burden. The context-specific challenges identified in this study provide valuable insights for designing effective mental health interventions across diverse...
- The intergenerational health, social care, and justice system contacts associated with household substance misuse in Walesby Hywel T Evans on 23 Gennaio 2026
CONCLUSION: SMHH children experience significant disparities, including higher deprivation, adverse birth outcomes, mental health issues, social care involvement, and SM-related criminal justice prosecutions. Evidence-based interventions and policy are needed to support adults and children in SMHH to mitigate the intergenerational impact.
- Alcohol withdrawal : benzodiazepines, neither automatic nor systematicby Augustin Curt on 22 Gennaio 2026
The CIWA-Ar (Clinical Institute Withdrawal Assessment for Alcohol-revised) is the gold standard for assessing the severity of alcohol withdrawal. It allows the dosage of benzodiazepines to be adjusted according to symptom intensity rather than prescribing them at a fixed dose, with the aim of limiting prolonged use and the associated risk of dependence. Randomized trials have shown that this approach reduces both the total amount of benzodiazepines administered and the duration of treatment...
- Association between pre-operative adherence to positive airway pressure therapy and postoperative opioid use after lower limb arthroplasty in patients with obstructive sleep apnoeaby J K Wong on 23 Gennaio 2026
Poor sleep is known to have a negative impact on pain perception, and obstructive sleep apnoea is the most prevalent sleep disorder in adults. Current evidence is conflicting with respect to the benefits of positive airway pressure treatment on pain in patients with obstructive sleep apnoea, which leaves the question of obstructive sleep apnoea as a modifiable factor in pain syndromes unanswered. We conducted a retrospective cohort study of United States of America veterans with obstructive...
- Pairing extinction training with vagus nerve stimulation (VNS) reduces drug-seeking by altering activity in afferents to the medial prefrontal cortexby Christopher Driskill on 23 Gennaio 2026
Relapse triggered by drug-associated cues or stress remains a major challenge in treating substance use disorders (SUDs), as re-exposure reliably provokes craving and reinstatement of drug seeking. Extinction-based interventions can reduce cue reactivity, yet extinction learning is often weak or context-dependent, limiting its clinical impact. Vagus nerve stimulation (VNS) enhances learning-related plasticity via widespread engagement of neuromodulatory systems and cortical circuits. Recent...
- Does Illicit Drug Use Increase Stroke Risk? A Systematic review, Meta-Analyses and Mendelian Randomization analysisby Megan Ritson on 22 Gennaio 2026
CONCLUSIONS: Our findings provide consistent observational and genetic evidence that several forms of substance misuse increase stroke risk, particularly cocaine, amphetamines and cannabis. These findings suggest important public health implications for prevention strategies targeting substance use disorders to mitigate stroke risk.
- Influence of Comorbidities on Colorectal Cancer Screening Participation and Mortalityby Rachel Corren on 22 Gennaio 2026
CONCLUSIONS: Patients with laboratory abnormalities were less likely to have a FIT order placed and completed, and experienced higher mortality, suggesting that screening was deferred by providers. Future studies should gather provider input to understand how patient-level electronic data could be considered in the implementation of screening services.
- Oral Health Disparities among Illicit Drug Users in the US: Secondary Analysis using Data from NHANES 2017-2018by Nada Farsi on 22 Gennaio 2026
CONCLUSION: Illicit drug use shows heterogenous associations with the development of caries; however, the impact differs according to the type of drug. The findings of this study emphasize the requirement for comprehensive dental management and integration of substance-abuse screening within oral healthcare services.
- Mental Health and ART Adherence in a Multisite International Study: The Mediating Roles of Social Support and Substance Use in People with HIVby Joseph Awad on 22 Gennaio 2026
ART adherence, essential to preventing disease progression for people living with HIV (PLHIV), remains challenged by factors like poor mental health condition, insufficient social support, and substance use. This study investigates the roles of social support and substance use as mediators in the relationship between mental health and antiretroviral therapy (ART) adherence among PLHIV in a multisite, international context. Cross-sectional data from N = 1598 PLHIV across eight countries were...
- Development and validation of screening tool for excessive and problematic use of internet and digital devices (STEPS-IDD) based on the WHO framework (ICD-11) for addictive behavioursby Yatan Pal Singh Balhara on 22 Gennaio 2026
CONCLUSION: STEPS-IDD is a psychometrically robust, brief yet comprehensive screening tool grounded in the ICD-11 framework, for the risk stratification in the context of addictive behaviours related to the use of the internet and digital devices.
- Decreased Nonvertebral Fracture Incidence with Zoledronate Use For >3 Years: Post Hoc Analysis of an RCTby Ian R Reid on 22 Gennaio 2026
The anti-fracture efficacy of most osteoporosis drugs is assessed in trials of up to three years duration. However, treatment of osteoporosis is required long-term, so it is important to know whether effectiveness of treatment changes over time. To-date, this information has only been available from open extensions of the treatment groups from clinical trials. Such data are subject to selective loss of frailer patients from the cohort, and no placebo comparator group is available to permit...
- Neuroimaging of Reality: A New Approach for Investigating Neural Bases of Decision-Making With Real-World Objectsby Damien Gabriel on 22 Gennaio 2026
CONCLUSIONS: Lab-Life is a validated methodological tool for combining behavioral and electrophysiological measures with real object manipulation. It offers a flexible and adaptable platform for decision-making, memory, or perceptual tasks, thereby bridging the gap between laboratory experiments and real-life conditions. Larger studies are warranted to further explore its impact on cognitive performance.
- Suicidal thoughts, problem gambling severity and utilisation of health care and social services: A population-based study in Finlandby Tiina Latvala on 21 Gennaio 2026
CONCLUSIONS: Suicidal thoughts are prevalent among persons harmed by problem gambling. Social and health service systems need to better recognise the association between gambling and co-occurrent suicidal thoughts. In addition, services need to be developed to offer effective treatment and support with high levels of integration.
- The Appendicitis Gamble-to Cut or to Keepby Anthony Charles on 21 Gennaio 2026
No abstract
- Social Comparison Modulates Outcome Evaluation: Neural Mechanisms of Emotional-Cognitive Processing in Gain and Loss Framesby Ming Peng on 21 Gennaio 2026
People usually evaluate themselves in comparison to others, and this can occur in three directions. Upward comparisons occur when comparing oneself to a superior person, parallel comparisons occur when comparing oneself to a similar person, and downward comparisons occur when comparing oneself to an inferior person. The present study explores how social comparison influences individual decision-making and the associated neural mechanisms within gain/loss frames. Using a two-option gambling task,...
- Acceptability and Feasibility of a Digital Mindfulness-Based Intervention for Anorexia Nervosa and Bulimia Nervosaby Margaret Sala on 23 Gennaio 2026
OBJECTIVE: There is a great need for the development of scalable augmentations to treatments for anorexia nervosa (AN) and bulimia nervosa (BN), as most individuals with AN/BN are currently not able to access treatment. Mindfulness-based interventions (MBIs) may be promising for AN/BN and lend themselves well to digital delivery, increasing access. We aimed to develop and test the initial acceptability and feasibility of Mindful Courage, a digital MBI for AN/BN and atypical AN/BN.
- Associations Among Binge Eating Behaviors, Emotion Regulation, and Chronotype in Female Greek University Studentsby Efi Karakosta on 23 Gennaio 2026
CONCLUSION: ER difficulties may be a key mechanism linking evening chronotype to BEBs. Future studies could explore whether interventions targeting ER and circadian alignment are beneficial for managing BEBs among individuals with an evening chronotype.
- Chrononutrition interventions for mental health: addressing atypical depression, ultra-processed food use disorder, and circadian dysregulationby Ignacio Cuaranta on 23 Gennaio 2026
CONCLUSION: Chrononutrition, alongside established psychiatric treatments, may offer a low-risk, high-yield strategy for improving mental health outcomes. Further research is needed to solidify consensus on definitions, assessment tools, and best practices for addressing ultra-processed food addiction and circadian disruption in clinical settings.
- Thigh gaps and filtered snaps: a qualitative study exploring opportunities to mitigate social media harm through content moderation for people with eating disordersby Pranita Shrestha on 22 Gennaio 2026
CONCLUSIONS: Manual safeguards place significant responsibility on users. This work supports informed distinctions between harmful, ambiguous and safe content and provides design insights for classification systems and adaptable automated moderation.
- Translation, Cross-Cultural Adaptation, and Psychometric Validation of the Malay Version of the Montreal Children's Hospital Feeding Scale for Screening Pediatric Feeding Difficulties in Malaysiaby Aimi Syahidah Zulkipli on 22 Gennaio 2026
CONCLUSION & IMPLICATIONS: The M-MCH-FS is a culturally relevant, valid and reliable screening tool for identifying pediatric feeding difficulties among Malaysian caregivers. Its brevity and psychometric robustness support its implementation in healthcare and community settings, facilitating early referral and intervention to enhance child health outcomes. WHAT THIS PAPER ADDS?: What is already known on the subject The MCH-FS is a brief, valid parent-report instrument used internationally to...
- Let's Co! The how-to of working within a co-production framework to devise, design and execute collaborative multisite clinical trialsby Sarah Maguire on 22 Gennaio 2026
OBJECTIVES: To document the steps undertaken in a full collaborative co-production design process undertaken between a group of lived experience, clinical and research collaborators to determine the selection and design of three large-scale, multisite, clinically focused studies (including two clinical trials) targeting eating disorders. This work formed part of a grant supporting the development of a National Centre for Research and Translation in Eating Disorders (AEDRTC) funded by the...
- Managing Family Accommodation in OCD: A Sibling-focused Case Studyby Archana Gupta on 22 Gennaio 2026
Family accommodation (FA) is prevalent in obsessive-compulsive disorder (OCD). When patients refuse treatment, the impacts are more severe-with poorer clinical outcomes, greater FA, and more caregiver burden. In these cases, caregiver interventions are an essential clinical priority. However, clinical documentation of structured, culturally informed interventions for FA and caregiver burden for adults with OCD, in the absence of patient participation, remains limited. This case study describes...
- Negotiating Stigma: Comparing the Experiences of Self-Identified and Clinically Diagnosed Men with OCD in Russiaby Elizaveta Shmidova on 22 Gennaio 2026
This cross-sectional qualitative study investigates how Russian men with obsessive-compulsive disorder (OCD) experience and manage mental health stigma, focusing on differences between those with a clinical diagnosis and those who self-identify with the disorder. Through in-depth interviews with eleven participants, the research explores meaning-making, disclosure practices, coping strategies, and the impact of masculine norms on help-seeking. Findings reveal that self-identified men often...
- Trauma-related pathways in obsessive-compulsive disorder: A systematic review of aetiology, symptom dimensions and severityby Margherita Zenoni on 22 Gennaio 2026
CONCLUSIONS: Trauma seems to significantly amplify OCD symptom severity and influence symptom presentation. Trauma-informed clinical assessment and tailored interventions should be integral to OCD treatment.
- Trade-off between speed and accuracy: associations between obsessive-compulsive symptoms and meticulousness in PANSby Helena Holmäng on 21 Gennaio 2026
CONCLUSIONS: Overall, while OCD symptom severity was not directly associated with reaction time, it significantly shaped response monitoring and touch positioning. These findings indicate a neurocognitive profile in PANS characterized by heightened self-monitoring and meticulousness, potentially reflecting mechanisms underlying OCD symptomatology. Our findings highlight the complex interplay between neurocognitive performance and OCD symptom severity in PANS, as revealed through digital...
- A case study on using quantile regression in psychiatry researchby Ravi G Shankar on 21 Gennaio 2026
Commonly used linear regression focuses only on the effect on the mean value of the dependent variable and may not be useful in situations where relationships across the distribution are of interest. This study aimed to appraise the utility of Quantile Regression (QR), a technique that can model any quantile value of the dependent variable. The primary aim of this study is to provide an overview of the QR method and its practical applications in psychiatric research. We demonstrated this with an...
- Lurasidone and Fluvoxamine Combination in Eating Disorders with Comorbid Obsessive-Compulsive Disorder: Preliminary Evidence from an Observational Studyby Francesco Monaco on 21 Gennaio 2026
CONCLUSIONS: Within the constraints of this small, all-female inpatient cohort, the findings illustrate directional, time-related changes compatible with global rehabilitation effects rather than drug-specific efficacy. The study demonstrates the feasibility-and methodological challenges-of applying Bayesian longitudinal modeling to incomplete clinical datasets. Future randomized or adaptive trials incorporating objective endpoints and data-quality pipelines are warranted to test whether...
- Occurrence, nature, impact and possible causal mechanisms of hallucinations across sensory modalities in people with an ultra-high risk of psychosisby Robert Dudley on 23 Gennaio 2026
CONCLUSIONS: Psychological therapies need to account for these experiences and could feasibly target them with treatments that focus on sleep or trauma.
- Discrete Deviations in Emotional Processing and Regulation Among Individuals With PTSD: Evidence of P300 and LPP Response Differencesby Carine El Jamal on 23 Gennaio 2026
Event-related potentials (ERPs) have been widely investigated to uncover associated neural deficits characterizing PTSD. However, existing studies investigating deviations in ERP components in PTSD compare differences among individuals with PTSD and healthy controls with no trauma history. Furthermore, associations between ERPs and PTSD symptom clusters are rarely investigated. Understanding how reliable neural potentials differ among individuals who develop versus do not develop PTSD following...
- A prospective investigation of whether parent psychopathology explains the relationship between parent maltreatment and offspring mental healthby Joanna Young on 23 Gennaio 2026
Previous research reports that offspring of parents with histories of childhood maltreatment are at increased risk for mental health problems, yet the mechanisms remain unclear. This study examines the extent to which parent psychopathology mediates the relationship between parent maltreatment history and offspring psychopathology. Using a prospective cohort design, individuals with documented histories of childhood maltreatment (ages 0 - 11 years) during 1967 - 1971 and demographically matched...
- Autologous vs. implant-based breast reconstruction and long-term mental disorder risk: a retrospective cohort study emulating a target trialby Danbee Kang on 23 Gennaio 2026
CONCLUSIONS: AR was associated with an elevated long-term risk of mental disorders, particularly among older patients. These findings underscore the need for age-specific, psychologically informed counseling when discussing reconstruction options in survivorship care.
- Predictors of postpartum depression in Syrian refugee women: indirect pathways between postmigration stress and depression through resilience and social supportby Taghreed N Salameh on 23 Gennaio 2026
CONCLUSION: Among the examined factors, only anxiety and resilience predicted PPD. Syrian refugee mothers in Türkiye might experience unique social life conditions that influence reporting postmigration stress and PTSD. Whereas social support and resilience served as significant indirect pathways between postmigration stress and PPD, the cross-sectional nature of the data precludes causal or temporal inferences. Yet, Interventions targeting anxiety and aimed at enhancing social support and...
- Flexible brain state engagement predicts cognitive control transdiagnosticallyby Jean Ye on 23 Gennaio 2026
Cognitive control supports adaptive responses in an ever-changing world. While alterations in cognitive control have been consistently observed in a range of psychiatric disorders, the neural mechanisms giving rise to this behavioral variation remain elusive. Here, we tested whether the ability to flexibly recruit recurring brain activation patterns (i.e., brain states) may serve as an intermediate phenotype supporting cognitive control in individuals with a spectrum of clinical symptoms. We...
- Effect of Repetitive Transcranial Magnetic Stimulation on the Symptoms and Brain Imaging in Patients with Fibromyalgia Syndrome: A Randomized Controlled Pilot Trialby Laura Ackermann on 30 Agosto 2025
CONCLUSIONS: While these results may be due to small sample size and short treatment duration, the findings of increased FA after active rTMS and higher functional connectivity between DLPFC and cerebellum in responders should be further explored.
- Guidelines on Treating Fibromyalgia With Nonpharmacological Therapies in Chinaby Xuanlin Li on 11 Giugno 2025
Fibromyalgia is a prevalent chronic condition marked by widespread pain, fatigue, and other debilitating symptoms. This guideline provides evidence-based recommendations for nonpharmacological treatments, developed by a multidisciplinary expert group, including specialists in rheumatology, rehabilitation, pain management, traditional Chinese medicine (TCM), and evidence-based medicine. The guideline follows the RIGHT checklist and is registered with the International Practice Guideline Registry...
- Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agentsby Fernanda M Q Silva on 5 Ottobre 2024
Fibromyalgia syndrome (FMS) is a chronic disorder characterized commonly by widespread musculoskeletal pain and fatigue, predominantly affecting women, with its complexity often leading to underdiagnosis and complicating treatment effectiveness. Transcranial magnetic stimulation (TMS) metrics are potential markers to optimize FMS treatments; however, evidence is limited. Our study aimed to explore the relationship between cortical excitability and inhibition, assessed through TMS markers, and...
- The Impact of Obesity as a Peripheral Disruptor of Brain Inhibitory Mechanisms in Fibromyalgia: A Cross-Sectional Studyby Walter Fabris-Moraes on 13 Luglio 2024
Background/Objective: Obesity, characterized by chronic inflammation, may serve as a surrogate marker for more dysfunctional peripheral inflammation, potentially exacerbating FM symptomatology. Given this premise, this study aimed to investigate the effects of obesity as an effect modifier on neural and clinical variables, specifically those indexing pain-compensatory mechanisms in FM symptoms. Methods: A cross-sectional study was conducted with 108 participants who underwent a standardized TMS...
- No add-on therapeutic benefit of at-home anodal tDCS of the primary motor cortex to mindfulness meditation in patients with fibromyalgiaby Perianen Ramasawmy on 20 Giugno 2024
CONCLUSIONS: Our findings demonstrate no synergistic or add-on efffect of anodal tDCS of the left M1 compared to the proper effect of MM in patients with fibromyalgia.
- Exercise effects on cortical excitability in pain populations: A systematic review and meta-analysisby Danielle Carolina Pimenta on 11 Giugno 2024
CONCLUSIONS: These findings suggest that exercise interventions positively affect pain relief by modifying corticospinal excitability, but their effects on ICI/ICF are still unclear. While the results are inconclusive, they provide a basis for further exploration in this area of research; future studies should focus on establishing standardized TMS measurements and exercise protocols to ensure consistent and reliable findings. A large-scale RCT that examines various exercise interventions and...
- Evaluating Alzheimer's disease with the TMS-EEG perturbation complexity indexby Brenna Hagan on 23 Gennaio 2026
The Perturbation Complexity Index-State Transitions (PCI^(ST)) measures the complexity of the brain's response to transcranial magnetic stimulation (TMS) using electroencephalography (EEG) and is sensitive to consciousness, such as minimally conscious states. Individuals with early-stage Alzheimer's disease (AD) show dysfunction of conscious processes, such as attention, working memory, episodic memory, and executive function, with relatively spared unconscious processes, such as procedural...
- Dopamine dysfunction beyond psychosis: Reevaluating its role in depression, anxiety, and obsessive-compulsive disorderby Samy Mansour on 21 Gennaio 2026
Dopaminergic dysfunction has traditionally been associated with psychotic disorders. However, emerging evidence implicates dopamine in a broader range of psychiatric conditions. This review critically reexamines dopamine's role beyond psychosis, focusing on major depressive disorder, anxiety disorders, and obsessive-compulsive disorder (OCD)-three high-burden conditions where current treatments remain suboptimal for many patients. This review is conducted to synthesise and critically evaluate...
- An update on the effects of cerebellar transcranial magnetic stimulation on cognitive functionby Yuxin Jiang on 11 Gennaio 2026
Transcranial magnetic stimulation (TMS), a non-invasive neuromodulation technique, is widely employed in treating various neurological and psychiatric disorders due to its favorable safety and tolerability profile. While traditionally recognized for its role in motor control, accumulating evidence implicates the cerebellum in regulating non-motor functions, including cognition. Historically, TMS research predominantly targeted cortical brain regions. However, leveraging the functional and...
- Revealing the Antidepressant Mechanism of Rhodiola rosea via Network Pharmacology: Integrated Molecular Docking and Dynamics Simulation Validationby Yifan Wang on 29 Dicembre 2025
Depression, affecting approximately 300 million people globally, is characterized by low mood, cognitive dysfunction, and neuroendocrine issues. Rhodiola rosea (R. rosea) has shown significant antidepressant activity, but its mechanisms are unclear. This study identified 62 chemical constituents in R. rosea extract, with 21 bioavailable compounds detected by UHPLC-Orbitrap Fusion TMS. A total of 3830 depression-related targets were collected from GeneCards, ChEMBL, DisGeNET, and OMIM, and 290...
- Editorial: Sleep disorders and cerebrovascular diseasesby Valerio Brunetti on 22 Dicembre 2025
No abstract
- Status and trends of transcranial magnetic stimulation research in Alzheimer's disease: A bibliometric and visual analysisby Wenyu Sun on 22 Dicembre 2025
Alzheimer's disease (AD) is a common neurodegenerative disease characterized by progressive memory loss and cognitive dysfunction and is the most common cause of dementia. In recent years, transcranial magnetic stimulation (TMS) has been widely used in the treatment of AD and has achieved better therapeutic results. In this study, from the perspective of bibliometrics, we used VOSviewer and CiteSpace software to visualize and analyze the research progress of TMS in AD in terms of scientific...
- Autologous vs. implant-based breast reconstruction and long-term mental disorder risk: a retrospective cohort study emulating a target trialby Danbee Kang on 23 Gennaio 2026
CONCLUSIONS: AR was associated with an elevated long-term risk of mental disorders, particularly among older patients. These findings underscore the need for age-specific, psychologically informed counseling when discussing reconstruction options in survivorship care.
- Sleep: State-of-the-Science Advances in the Journal of Neuropsychiatry and Clinical Neurosciencesby Melissa B Jones on 23 Gennaio 2026
No abstract
- Sleep Disorders in Moyamoya Disease: Prevalence, Risk Factors, and Impact on Functional Outcomesby Qingbao Guo on 23 Gennaio 2026
INTRODUCTION: Sleep disorders are prevalent but frequently overlooked in Moyamoya Disease (MMD), with their clinical impact remaining inadequately characterized. This study aimed to determine the prevalence of sleep disorders, assess their effect on functional outcomes, and identify independent predictors in MMD patients.
- Alpha-synuclein quantitative seed amplification assay predicts conversion to dementiaby Stefan Bräuer on 23 Gennaio 2026
INTRODUCTION: The alpha-synuclein seed amplification assay (SAA) has shown excellent performance in the detection of Lewy body pathology in cerebrospinal fluid (CSF). Lewy body pathology is prognostically relevant in patients at risk for dementia. Current assays only provide binary results, so there is a need to quantify the extent of pathology in living patients.
- Network dynamics of depression, anxiety, sleep disturbances, and suicidal symptoms in Chinese adolescents: a longitudinal cross-sectional and cross-lagged panel network analysisby Bin Sun on 23 Gennaio 2026
CONCLUSIONS: Central symptoms evolved during recovery, with subjective anxiety initially dominant but somatic symptoms becoming central over time. The early post-treatment period showed heightened symptom network activity, with sleep disturbances identified as robust predictors of subsequent affective deterioration. Findings support dynamic, network-informed interventions targeting evolving symptom centrality and predictive pathways, particularly addressing sleep-related symptoms and suicide...
- Disrupted gray matter structural covariance networks in chronic insomnia disorderby Zhonglin Li on 23 Gennaio 2026
CONCLUSIONS: This study establishes an association between sleep disturbances in CID and aberrations in both the GMV of specific sensory-motor network nodes (PreCG, PCL, PoCG) and their SCN topological properties, thereby providing new directions for elucidating the disorder's pathophysiology.
- Drugs for Migraine Prophylaxisby Hans Christoph Diener on 23 Gennaio 2026
CONCLUSION: The new prophylactic drugs against migraine are effective, well-tolerated, and especially useful for patients for whom traditional oral migraine prophylactic drugs and onabotulinum toxin A are ineffective, not tolerated, or contraindicated.
- Cost-Utility Analysis of Acupuncture for the Prevention of Episodic Migraine from a Lifetime Canadian Health System and Societal Perspectiveby Elizabeth C Wu on 23 Gennaio 2026
CONCLUSION: Acupuncture could be a cost-effective option for patients with episodic migraine. Future studies are encouraged to inform decisions regarding the use of acupuncture in the management of episodic migraine.
- How Good Are Neurologists? A Diagnostic Accuracy Study on the Performance of Neurologists in the Emergency Roomby Christoph J Schankin on 23 Gennaio 2026
CONCLUSION: In people with acute neurological deficits, the accuracy with which neurologists identify vascular origin is high and depends on neurological education. Experienced physicians should be involved early in the management of people with "code stroke."
- Investigation of the rimegepant effect on cerebral and extracerebral arteries during migraine attacks: a longitudinal magnetic resonance angiography studyby Basit Ali Chaudhry on 23 Gennaio 2026
Migraine is a leading cause of disability worldwide, and triptans, the most widely used acute treatment, act through vasoconstriction and are contraindicated in patients with vascular disease. Rimegepant, a calcitonin gene-related peptide receptor antagonist, is proposed as a non-vasoconstrictive alternative, but its direct vascular effects during spontaneous migraine attacks have not been examined. This was a prospective, longitudinal study conducted at a single academic imaging centre between...
- Efficacy and safety of magnesium prophylaxis in children with migraine without auraby Elif Yuksel Karatoprak on 23 Gennaio 2026
CONCLUSION: Magnesium oxide appears to be a well-tolerated, safe, and potentially effective prophylactic option for children with migraine without aura. It was associated with a significant reduction in attack frequency, disability scores, and improved quality of life. Despite promising results, the absence of a control group and serum magnesium data are notable limitations. Further prospective, randomized controlled studies are required to confirm these findings and establish the most effective...
- Spreading depolarization activates the cGAS-STING pathway and drives cranial nociception: therapeutic potential of STING modulationby Kadir Oguzhan Soylu on 22 Gennaio 2026
No abstract
- Acceptability and Feasibility of a Digital Mindfulness-Based Intervention for Anorexia Nervosa and Bulimia Nervosaby Margaret Sala on 23 Gennaio 2026
OBJECTIVE: There is a great need for the development of scalable augmentations to treatments for anorexia nervosa (AN) and bulimia nervosa (BN), as most individuals with AN/BN are currently not able to access treatment. Mindfulness-based interventions (MBIs) may be promising for AN/BN and lend themselves well to digital delivery, increasing access. We aimed to develop and test the initial acceptability and feasibility of Mindful Courage, a digital MBI for AN/BN and atypical AN/BN.
- Associations Among Binge Eating Behaviors, Emotion Regulation, and Chronotype in Female Greek University Studentsby Efi Karakosta on 23 Gennaio 2026
CONCLUSION: ER difficulties may be a key mechanism linking evening chronotype to BEBs. Future studies could explore whether interventions targeting ER and circadian alignment are beneficial for managing BEBs among individuals with an evening chronotype.
- Chrononutrition interventions for mental health: addressing atypical depression, ultra-processed food use disorder, and circadian dysregulationby Ignacio Cuaranta on 23 Gennaio 2026
CONCLUSION: Chrononutrition, alongside established psychiatric treatments, may offer a low-risk, high-yield strategy for improving mental health outcomes. Further research is needed to solidify consensus on definitions, assessment tools, and best practices for addressing ultra-processed food addiction and circadian disruption in clinical settings.
- Thigh gaps and filtered snaps: a qualitative study exploring opportunities to mitigate social media harm through content moderation for people with eating disordersby Pranita Shrestha on 22 Gennaio 2026
CONCLUSIONS: Manual safeguards place significant responsibility on users. This work supports informed distinctions between harmful, ambiguous and safe content and provides design insights for classification systems and adaptable automated moderation.
- Translation, Cross-Cultural Adaptation, and Psychometric Validation of the Malay Version of the Montreal Children's Hospital Feeding Scale for Screening Pediatric Feeding Difficulties in Malaysiaby Aimi Syahidah Zulkipli on 22 Gennaio 2026
CONCLUSION & IMPLICATIONS: The M-MCH-FS is a culturally relevant, valid and reliable screening tool for identifying pediatric feeding difficulties among Malaysian caregivers. Its brevity and psychometric robustness support its implementation in healthcare and community settings, facilitating early referral and intervention to enhance child health outcomes. WHAT THIS PAPER ADDS?: What is already known on the subject The MCH-FS is a brief, valid parent-report instrument used internationally to...
- Let's Co! The how-to of working within a co-production framework to devise, design and execute collaborative multisite clinical trialsby Sarah Maguire on 22 Gennaio 2026
OBJECTIVES: To document the steps undertaken in a full collaborative co-production design process undertaken between a group of lived experience, clinical and research collaborators to determine the selection and design of three large-scale, multisite, clinically focused studies (including two clinical trials) targeting eating disorders. This work formed part of a grant supporting the development of a National Centre for Research and Translation in Eating Disorders (AEDRTC) funded by the...
- Depression and Cognitive Outcomes: Linking the Mayo Clinic Study of Aging and Rochester Epidemiology Projectby Jeremy A Syrjanen on 23 Gennaio 2026
CONCLUSIONS: Depression was associated with baseline and longitudinal measures of cognition among community-dwelling older adults. Only individuals receiving antidepressants had a significantly increased risk for incident MCI and dementia.
- Visual scanpaths predict treatment response in children and adolescents with social anxiety disorderby Johan Lundin Kleberg on 23 Gennaio 2026
Treatment response in pediatric social anxiety disorder (SAD) is highly variable, and symptoms may be maintained by maladaptive attention. A previous study found that youth with SAD scan a more restricted area of faces than healthy controls during emotion recognition, potentially limiting interpretation of social cues. The current study followed up on these results by examining whether restricted face scanning 1) predicts response to psychological treatment, and 2) changes with successful...
- Construction of a psychological intervention program for fear of recurrence in semi-disabled patients after stroke: a pilot studyby Lingyu Han on 23 Gennaio 2026
CONCLUSIONS: The integrated psychological intervention program, which combined psychological support, CBT, rehabilitation training, and social support, was effective in reducing the fear of recurrence in semi-disabled patients after stroke.
- Interpreter Child Syndrome Leading to Parentification and Anxiety in a Refugee Girl: A Case Reportby Elanur Yolal Karimov on 23 Gennaio 2026
Language brokering, in which children interpret for non-native-speaking parents, is common among refugee families but is often overlooked as a potential psychosocial stressor. Studies indicate that 75-90% of immigrant and refugee children serve as language brokers, with 18-20% experiencing clinically significant psychological distress related to this role. Excessive or emotionally charged interpreting may lead to parentification, anxiety, and developmental disruption. We present a case of a...
- CHI3L1 monoclonal antibody therapy mitigates cognitive impairment by inhibiting neuroinflammation through ERK and NF-kappaB pathway in Tg2576 miceby Hyeon Joo Ham on 23 Gennaio 2026
INTRODUCTION: Alzheimer's disease (AD) is neurodegenerative disorder characterized by chronic inflammation in the brain. Chitinase-3-like 1 (CHI3L1), a secreted glycoprotein that is upregulated in a variety of diseases with chronic inflammation, represents a promising target for AD. Here, we studied the inhibitory effect of a novel CHI3L1 monoclonal antibody (H1) on memory impairment and neuroinflammation in Tg2576 transgenic mice.
- Effectiveness of trauma-focused cognitive behavioral therapy on quality of trauma-related memory, dissociative experiences, and body image dissatisfaction in adolescents with complex post-traumatic stress disorder: A randomized controlled clinical trialby Homa Shahkaram on 23 Gennaio 2026
CONCLUSIONS: Overall, it is suggested that correction centers and other related centers utilize the results obtained from this study as scientific and practical guides to improve the mental health status of adolescents with CPTSD.
- Cost-Effectiveness of Transcranial Magnetic Stimulation for Methamphetamine Use Disorder during Pregnancyby Rana Jawish on 21 Gennaio 2026
BACKGROUND: Methamphetamine use disorder (MUD) during pregnancy is associated with adverse maternal and perinatal outcomes, including increased risk of preterm birth, cesarean delivery, neonatal intensive care unit admission, placental abruption, and maternal or perinatal death. For the few evidence-based treatments for MUD, including transcranial magnetic stimulation (TMS) and injectable naltrexone with bupropion combination, there are few data available for pregnant individuals.
- High Frequency Left-Sided Repetitive Transcranial Magnetic Stimulation (rTMS) for Post Traumatic Stress Disorder With Comorbid Major Depressive Disorderby Natalie Seiler on 21 Gennaio 2026
ObjectiveRepetitive transcranial magnetic stimulation (rTMS) is an established treatment for comorbid post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). However, there are no universal protocols regarding the type of rTMS recommended, including among military and first responders. This study aimed to describe high frequency rTMS applied to the left dorsolateral prefrontal cortex (DLPFC) administered to inpatients with comorbid PTSD and MDD at Ward 17, Austin Health in...
- Evaluation of Functional Magnetic Stimulation Parameters and Effectiveness for Neurogenic Detrusor Overactivity: A Systematic Review and Network Meta-Analysisby Hongxia Pan on 17 Gennaio 2026
CONCLUSIONS: FMS, particularly SMS, significantly improves bladder storage capacity and reduces incontinence in patients with NDO. Among evaluated parameters, 15-Hz stimulation and an eight-week regimen were associated with the greatest improvements in MCC; however, these parameters were analyzed independently, and evidence regarding their combined effects or interactions across stimulation sites is limited. TMS showed mixed effects, increasing AVV but decreasing FDV, suggesting enhanced bladder...
- Exploring Risk Factors and Neurophysiological Mechanisms Underlying the Development of Chronic Postsurgical Pain After Thoracic Surgery: Protocol for an Observational Feasibility Studyby Mustaali Hussain on 12 Gennaio 2026
CONCLUSIONS: This protocol details our study design for a feasibility study exploring the neurophysiological markers and patient characteristics associated with the development of CPSP. Demonstration of feasibility is expected to lead to a larger study. Improved understanding of the risk factors and mechanisms underlying CPSP may inform the delivery of targeted therapies and preventive measures to reduce the incidence of CPSP after thoracic surgery.
- Oxidative Potential of Atmospheric Particulate Matter: A Review of the Role of Metal-Organic Interactions, Mechanistic Insights, and Key Determinantsby Manfei Lin on 6 Gennaio 2026
Oxidative stress, resulting from antioxidant depletion or excessive reactive oxygen species (ROS) production, is a key mechanism linking ambient particulate matter (PM) exposure to adverse health effects. The oxidative potential (OP) of PM, a measure of inhaled PM's capacity to deplete antioxidants or generate ROS, is largely driven by transition metals (TMs) such as iron and copper. However, coexisting organic matter also modulates OP, both directly through its own redox activity and indirectly...
- Accelerated Theta Burst Stimulation Transcranial Magnetic Stimulation (iTBS-TMS) Pururauka program for severe depressive episode and suicide ideationby Hesed Virto-Farfan on 2 Gennaio 2026
CONCLUSION: The Pururauka accelerated iTBS protocol was associated with rapid and sustained reductions in depressive symptoms and suicidal ideation in individuals with severe depressive episodes and insufficient response to previous medications. These preliminary findings warrant confirmation in future randomized controlled trials.
