AGGIORNAMENTO SCIENTIFICO IN TEMPO REALE FORNITO DA:
- Advancing Network Meta-Analysis in Non-Invasive Brain Stimulation: Optimizing Post-Stroke Mood through Combined Therapiesby Rui Li on 23 Aprile 2025
CONCLUSIONS: The findings suggest that optimized combination NIBS therapies offer superior outcomes for post-stroke depression and anxiety. HFrTMS_LFrTMS_WM was the most effective for depression and independence in activities of daily living (ADLs), while tDCS_psychotherapy and TUS_WM were particularly effective for anxiety. These results highlight the clinical potential of integrated NIBS strategies for post-stroke mood optimization and call for further research to refine treatment protocols...
- Effects of Transcranial Magnetic Stimulation on Cognitive-Affective Task-Based Functional Connectivityby Merideth A Addicott on 21 Aprile 2025
Objective: Repetitive transcranial magnetic stimulation (rTMS) uses electromagnetic fields to induce electrical currents in the superficial cortex, and this electric signal is believed to propagate to functionally connected distal brain regions. We previously reported that rTMS targeting the postcentral gyrus affected resting-state functional connectivity with the posterior insula. The current study investigated whether rTMS targeting the postcentral gyrus would affect task-based functional...
- Effects of Combined Transcranial Magnetic Stimulation and Photobiomodulation in Mild Cognitive Impairment: A Randomized Controlled Trialby Da Han on 20 Aprile 2025
This study evaluates the synergistic effects of transcranial magnetic stimulation (TMS) and transcranial photobiomodulation (tPBM) on working memory (WM) in mild cognitive impairment (MCI) patients. In a randomized controlled trial with 88 participants, utilizing a complex WM task (ΔK = 6.41, p = 0.004) alongside functional near-infrared spectroscopy (fNIRS) to assess cognitive performance and neural correlates(neural metrics from fNIRS indicated enhanced functional connectivity [p = 0.015] and...
- Diagnostic utility of threshold tracking TMS paradigms in early amyotrophic lateral sclerosisby Aicee Dawn Calma on 18 Aprile 2025
CONCLUSION: While threshold tracking TMS reliably differentiated ALS from mimic disorders, the present study established better diagnostic utility with the serial ascending threshold tracking TMS paradigm.
- Neural correlates of psychotherapy in mental disorders: A meta-analysis of longitudinal resting-state fMRI studiesby Ya-Xin Zheng on 17 Aprile 2025
CONCLUSIONS: The current study indicates that the clinical efficacy of psychotherapy may be modulated by insular and right inferior frontal gyrus through neurological perspective. This contributes to our understanding of the neurobiological mechanisms of psychotherapy and provides valuable insights into improving precise targeting interventions for individuals with mental disorders.
- Harnessing neuroimaging-guided transcranial magnetic stimulation for precision therapy in substance use disordersby Smita Sahay on 16 Aprile 2025
Substance use disorders (SUDs) are a critical public health challenge characterized by high relapse rates, with existing treatments often proving inadequate. The focus of this review is to provide an update on the current state of transcranial magnetic stimulation (TMS) as a therapeutic intervention for SUDs and discuss neuroimaging-guided TMS practices. This review explores the neurobiology underlying SUDs, emphasizing the roles of the prefrontal cortex, striatal circuits, and dopaminergic...
- Factors affecting recurrence of pain after surgery for chronic pancreatitis: A retrospective and prospective studyby Sunil Kumar Godara on 25 Aprile 2025
CONCLUSIONS: The incidence of recurrent pain in CP patients post-surgery was 56.8%, with a significant reduction in pain intensity postoperatively. Patients who required preoperative IV analgesics and underwent endoscopic interventions demonstrated a higher risk of recurrent pain. Neuropathic pain was not identified as a cause of pain recurrence in this study.
- Protein Kinases as Mediators for miRNA Modulation of Neuropathic Painby Leah Chang on 25 Aprile 2025
Neuropathic pain is a chronic condition resulting from injury or dysfunction in the somatosensory nervous system, which leads to persistent pain and a significant impairment of quality of life. Research has highlighted the complex molecular mechanisms that underlie neuropathic pain and has begun to delineate the roles of microRNAs (miRNAs) in modulating pain pathways. miRNAs, which are small non-coding RNAs that regulate gene expression post-transcriptionally, have been shown to influence key...
- Sustained Release of alphaO-Conotoxin GeXIVA[1,2] via Hydrogel Microneedle Patch for Chronic Neuropathic Pain Managementby Rongyan He on 25 Aprile 2025
Chronic neuropathic pain severely impairs quality of life, with current therapies often causing adverse effects. Our research group identified αO-conotoxin GeXIVA[1,2] as a potent analgesic candidate derived from marine cone snails. However, its clinical application is limited by rapid clearance and complex administration. This study developed a sustained-release hydrogel microneedle patch encapsulating GeXIVA[1,2] to address these challenges. Optimized 4:3 (w/w) polyvinyl alcohol (PVA)-sucrose...
- Treatment of insomnia, restless legs, cramps, and pain associated with chronic kidney disease: results from a multinational survey of kidney supportive care practiceby Kurinji Nalankilli on 24 Aprile 2025
CONCLUSIONS: There is wide variation in treatment approaches to common symptoms affecting people living with advanced CKD or kidney failure, both within and between countries, indicating a need for evidence-based guidelines and further randomised studies to inform practice.
- Treatment of chronic refractory coccydynia with peripheral nerve field stimulation: a novel caseby George Tokas on 24 Aprile 2025
Coccydynia or coccyx pain is a rare form of low back pain located below the sacrum and above the anus. The causes of this condition vary, including previous trauma, underlying conditions (such as infection or neoplasm), and idiopathic causes. Our purpose was to describe the successful treatment of chronic refractory coccydynia with the application of sacral area neuromodulation. A 54-year-old female patient had a 9-year history of chronic drug-resistant coccydynia associated with low back pain...
- Isolated Neuropathic Bladder Associated With Human T-lymphotropic Virus Type 1 Infection Precipitating Acute Focal Bacterial Nephritis: A Case Reportby Takahiro Minamii on 24 Aprile 2025
A 71-year-old woman with previously undiagnosed human T-lymphotropic virus type 1 (HTLV-1) infection presented with fever, urinary difficulties, acute abdominal pain, and severe acute kidney injury (AKI). Diagnostic evaluations confirmed acute pyelonephritis (APN) and acute focal bacterial nephritis (AFBN). Despite antibiotic treatment, she required temporary hemodialysis and eventually developed chronic kidney disease. This case highlights the importance of considering APN and AFBN as...
- Updates on digital mental health interventions for children and young people: systematic overview of reviewsby Shaun Liverpool on 25 Aprile 2025
Digital mental health interventions (DMHIs) are increasingly recommended for children and young people (CYP) as a promising way to prevent and treat mental health problems. Here, we summarised and consolidated findings from existing systematic reviews to provide an overview of what is known, and which areas need further investigation. Systematic searches were conducted until January 2024 using PubMed, PsycINFO, MEDLINE, CINAHL, Scopus and Google Scholar. Records were screened against predefined...
- COVID-19 in Morocco: Nurses' Knowledge of Anti-COVID-19 Vaccines and Their Involvement in Vaccine Vigilanceby Fatima Zahra Laamiri on 25 Aprile 2025
The COVID-19 pandemic has highlighted the crucial role of nurses in managing health crises, particularly in implementing vaccination campaigns launched in many countries worldwide. This descriptive study assesses nurses' knowledge of COVID-19 vaccines and their involvement in vaccine vigilance. Conducted over four months in 2022 among 200 primary healthcare nurses in the Fès-Meknès region, the data were collected using a questionnaire developed and validated by a multidisciplinary team. The...
- A Historical Review on the Andalusian Physicians and the Treatment of Mental Healthby H Alotaibi on 25 Aprile 2025
Andalusian medicine, characterized by its holistic approach to healthcare, placed a unique emphasis on the interconnectedness of physical health, emotional well-being, and spiritual harmony. Eminent scholars, including physicians like Ibn Sina, Ibn al-Nafis, and Ibn Wafid, pioneered advancements in understanding mental disorders, the complexities of the human psyche, and the intricate relationship between the body and mind. One of the most enduring legacies of Andalusian contributions to mental...
- Melatonin supplementation: new insights into health and diseaseby Tatiana Palotta Minari on 25 Aprile 2025
CONCLUSION: Melatonin supplementation is not a universal solution but a potentially valuable tool in specific contexts. Its benefits are most evident in sleep regulation and certain neurodegenerative conditions. However, significant gaps in research, including inconsistent methodologies, small sample sizes, and limited data on long-term effects, necessitate further robust clinical trials. Individualized recommendations and cautious interpretation of findings are essential, particularly given the...
- Application effect of pelvic floor function exercise based on health belief model in patients with benign prostatic hyperplasia after electrocauteryby Juan Xiao on 25 Aprile 2025
CONCLUSION: PFMT guided by the HBM significantly improved urinary and erectile function, reduced postoperative complications, and enhanced psychological well-being in patients with BPH following TURP. These benefits should be evaluated in future longitudinal studies to assess their sustainability.
- Brief Report: Mental Health and Wellbeing Across the Autism Assessment Experienceby Philippa Tivey on 25 Aprile 2025
CONCLUSION: Young people waiting for autism assessment experience varied, enduring and impactful difficulties with mental health: comprehensive assessment is required to meet their needs. At a group-level, there is no good reason to delay autism assessment for fear of worsening mental health symptoms.
- Brief Report: Mental Health and Wellbeing Across the Autism Assessment Experienceby Philippa Tivey on 25 Aprile 2025
CONCLUSION: Young people waiting for autism assessment experience varied, enduring and impactful difficulties with mental health: comprehensive assessment is required to meet their needs. At a group-level, there is no good reason to delay autism assessment for fear of worsening mental health symptoms.
- Prevalence and impact of financial toxicity in older patients with cancer: a prospective observational study in Indiaby Vanita Noronha on 25 Aprile 2025
CONCLUSIONS: Identifying the factors contributing to financial toxicity will help make the cancer treatment journey smoother, more accessible and improve compliance to therapy for older patients.
- The presence of abnormal palpatory findings in the sacrococcygeal area is correlated with chronic pelvic pain: a cross-sectional studyby Daniele Origo on 25 Aprile 2025
CONCLUSIONS: Sacrococcygeal and pelvic floor APFs appear to be important clinical markers of CPP/CPPS. Their presence may help identify patients who could benefit from targeted manual therapy as part of multimodal management. Further research should evaluate the prognostic value of these findings.
- Application effect of pelvic floor function exercise based on health belief model in patients with benign prostatic hyperplasia after electrocauteryby Juan Xiao on 25 Aprile 2025
CONCLUSION: PFMT guided by the HBM significantly improved urinary and erectile function, reduced postoperative complications, and enhanced psychological well-being in patients with BPH following TURP. These benefits should be evaluated in future longitudinal studies to assess their sustainability.
- Alcohol Use Disorder Diagnoses Among Individuals Who Take HIV Preexposure Prophylaxisby Anton L V Avanceña on 25 Aprile 2025
CONCLUSIONS AND RELEVANCE: This population-based cohort study found that nearly 15% of individuals who took PrEP had an AUD diagnosis within 6 months of PrEP initiation; individuals with an AUD diagnosis were more likely to have co-occurring mental health conditions, and less than 9% received any FDA-approved MAUD. These findings suggest that interventions are needed to improve AUD services among individuals who take PrEP.
- Mercuric Chloride Aggravates Hyperglycemia-Induced Anxiety and Depressive-Like Behaviors in Type 2 Diabetic Rats: Breakdown of the Antioxidant Defense Systemby Benloughmari Douae on 25 Aprile 2025
Introduction Type 2 diabetes mellitus (T2DM) is a global health problem frequently associated with biochemical disturbance and also, with a range of mental health disorders including such as anxiety and depression. Whereas, mercury chloride (HgCl₂) is a common environmental pollutant, which is neurotoxic and induces oxidative stress, especially in metabolic disorders like diabetes. The purpose of this investigation is to evaluate the interaction between hyperglycemia-induced oxidative stress and...
- Substance use disorder recovery research opportunities: perspectives from a federal interagency workgroupby Peter Gaumond on 25 Aprile 2025
In 2024, the Office of National Drug Control Policy (ONDCP) convened an interagency working group (IWG) comprised of 30 federal agencies to identify federal recovery research gaps and opportunities on recovery from substance use disorder (SUD). This article outlines the process undertaken to identify these research opportunities and describes four core research topic areas and three cross-cutting themes and provides the rationale for their selection. It also identifies potential pathways for...
- Availability of Cognitive Remediation Therapy in United States Mental Health Facilities Serving Older Adults: A Statistical Studyby Tajudeen O Basiru on 25 Aprile 2025
CONCLUSION: This study highlights the relative unavailability of CRT, indicating a need for more interest in evidence-based nonpharmacological treatment options for cognitive decline in the aging population.
- Medication- and Non-Medication-Related Causes of Relapse in First-Episode Psychosis Patients Admitted to Sultan Qaboos University Hospitalby Yamamh M Al-Jubori on 25 Aprile 2025
Background First-episode psychosis (FEP) patients often respond well to treatment; however, they remain at high risk of relapse. The factors contributing to relapse have been understudied, particularly in the Middle East. Aim This study aimed to identify both medication- and non-medication-related factors associated with relapse in FEP patients admitted to the Department of Behavioral Medicine (inpatient or outpatient) at Sultan Qaboos University Hospital (SQUH). Methods This retrospective...
- Investigations Into the Urinary Metabolite Elimination Profile of the Selective Androgen Receptor Modulator S-23 in Studies Mimicking Contaminated Product Ingestion for Doping Control Purposesby Hana Alhalabi on 25 Aprile 2025
Selective androgen receptor modulators (SARMs) have repeatedly been reason of adverse analytical findings (AAFs) in routine doping controls. Among these, S-23 has been identified in five AAFs reported in 2022. In addition to intentional doping, inadvertent exposure through contaminated dietary supplements has emerged as a significant concern, purportedly as well as evidently contributing to AAFs involving SARMs. Thus, the differentiation of inadvertent intake and intentional abuse of S-23 is of...
- The Contribution of Forensic Medical Investigations in Road Accident Deathsby Matteo Antonio Sacco on 25 Aprile 2025
Forensic medicine plays a crucial role in investigating fatalities resulting from road accidents, particularly in assessing physical injuries and toxicological findings to determine their correlation with accident dynamics. The expertise of forensic pathologists is essential not only in establishing the cause of death but also in reconstructing the events leading to the fatal outcome and identifying the potential influence of alcohol or psychoactive substances. The presence of such substances in...
- Doping Detection Based on the Nanoscale: Biosensing Mechanisms and Applications of Two-Dimensional Materialsby Jingjing Zhao on 25 Aprile 2025
Doping undermines fairness in sports and threatens athlete health, while conventional detection methods like LC-MS and GC-MS face challenges such as complex procedures, matrix interferences, and lengthy processing times, limiting on-site applications. Two-dimensional (2D) materials, including graphene, MoS(2), and metal-organic frameworks (MOFs), offer promising solutions due to their large surface areas, tunable electronic structures, and special interactions with doping agents, such as...
- Chasing the High, Losing the Beat: A Case of Cocaine-Induced Myocardial Infarctionby Saurabh Kumar Singh on 25 Aprile 2025
Cocaine use is a well-established risk factor for various cardiovascular complications, including acute myocardial infarction (MI). The pathophysiological mechanisms responsible for cocaine-induced MI are multifactorial, encompassing coronary vasoconstriction, increased myocardial oxygen demand, and thrombosis. While cocaine-related cardiovascular events are more commonly seen in individuals with pre-existing risk factors, cases involving young, otherwise healthy individuals remain rare, yet...
- Project RETAIN: Providing Integrated Care for People With HIV Who Use Cocaineby Lisa R Metsch on 25 Aprile 2025
CONCLUSIONS: Only a minority of PWH who used cocaine became virally suppressed over the 12-month study, with no effect of the integrated intervention. Patients in the intervention did have reduced psychological distress postintervention. Despite more substance use treatment in the intervention, both groups declined equally in substance use. Interventions that improve retention in care and viral suppression are needed for this vulnerable population, including those that address their other...
- Banknotes as a Source of Drug and Pharmaceutical Contamination of the Populationby Nina Petrovičová on 25 Aprile 2025
This study investigates the potential contamination of cash register employees in the Slovak Republic with 148 selected pharmaceuticals, illicit drugs, and their metabolites. Of these, 42 substances were detected, and it was found that the target group-cashiers-regularly handle large volumes of banknotes, increasing their exposure to contaminants compared to the general population. This study revealed that commonly prescribed and over-the-counter medications significantly contribute to the...
- Lung Transplantation From Donors With a History of Substance Useby David Li on 25 Aprile 2025
CONCLUSION: A history of donor substance use was common and in general not associated with worse outcomes, aside from heavy donor smoking. These findings may have implications for allocation and post-transplant graft dysfunction.
- Oral fluid device performance in identifying amphetamine, methamphetamine, and cocaine use in Brazilian driversby Bruno Pereira Dos Santos on 25 Aprile 2025
Stimulant use while driving is a high-risk factor for collisions and fatalities. In recent years, several strategies to curtail impaired driving were employed on highways, including on-site oral fluid testing. This study evaluated four roadside oral fluid testing devices (AquilaScan®, Dräger DrugTest®, Druglizer®, and DrugWipe®) for the detection of amphetamine, methamphetamine, and cocaine in oral fluid from Brazilian drivers. Overall, 8,985 screening tests were conducted, and LC-MS/MS analysis...
- Altered integrated and segregated states in cocaine use disorderby Yi Zheng on 24 Aprile 2025
INTRODUCTION: Cocaine use disorder (CUD) is a chronic brain condition that severely impairs cognitive function and behavioral control. The neural mechanisms underlying CUD, particularly its impact on brain integration-segregation dynamics, remain unclear.
- Unraveling Antibacterial Mechanisms of Surfactants against Staphylococcus aureus via Single-Cell Raman Spectroscopyby Xiaoshan Zheng on 25 Aprile 2025
Antibacterial agents, particularly surfactants, play crucial roles in the personal and home care industries. However, current methods for assessing their efficacy and mechanism are commonly time-consuming and expensive. Here, we established a ramanome-based approach to investigate the antibacterial mechanisms of cationic and anionic surfactants with varying alkyl chain lengths against Staphylococcus aureus as a model. Our findings further elucidate the synergy between anionic surfactants and...
- Analysis of the correlation between anthropometric indices and levels of selected hormones in relation to problematic internet use: blood parameters in problematic internet useby Natalia Tomska on 24 Aprile 2025
The aim of the study was to assess the relationship between anthropometric indices and the concentration of hormonal parameters in relation to problematic Internet use or even addiction. The study was conducted in 2020-2021 on a group of 427 men aged 18-30 (24.82 ± 3.83) who declared that they used the Internet and played computer games and/or online games, including gambling. Participation in the study was voluntary and anonymous. Anthropometric indices, HOMA-IR as well as biochemical and...
- Barriers to Gambling Treatment Among American Military Personnel: A Qualitative Studyby Noa Vana on 24 Aprile 2025
Gambling disorder (GD) poses a significant public health problem, with treatment access frequently hindered by barriers. This study sought to identify the unique internal and external barriers encountered by military personnel with GD using a qualitative descriptive method. Twenty-eight United States military veterans and service members (SMs) were recruited through purposeful sampling strategies and interviewed using a semi-structured interview format. Content analysis revealed two main themes:...
- Managing free-roaming domestic dog populations using surgical sterilisation: a randomised controlled trialby H R Fielding on 24 Aprile 2025
Free-roaming domestic dogs (FRDs) are among the most abundant carnivores on earth and have coexisted with humans for over 15,000 years, yet increases in negative interactions and the transmission of zoonotic diseases, precipitates calls for population management. Despite significant investment in FRD sterilisation in India, where rabies is endemic, there is limited evidence of its impact on reducing FRD population sizes. Therefore, robust evaluation of the effectiveness of fertility control...
- The influence of empathic concern on evaluative processing in self and charity outcomesby Min Tan on 23 Aprile 2025
Empathy plays a crucial role in determining how one understands others' emotional experiences and behavioral decisions. This study aimed to explore whether empathic concern affects the processing of self-related and charity-related outcome evaluations. In this study, participants performed gambling tasks for themselves and low- and high-empathy charities. The behavioral results showed that low-empathy charities had a significantly higher risk rate than the self, whereas there was no significant...
- Brinkmanship in intragenomic conflictby Patrick Kennedy on 23 Aprile 2025
When the Darwinian interests of genes in the genome collide, intragenomic conflicts evolve. Recent advances in social evolution predict that intragenomic conflicts shape diverse phenotypes. However, principles governing which side wins remain unresolved. Here, we use game theory to predict that power asymmetries arise from differences in appetite for risk between rival genes in 'wars of nerve'. We focus on 'genomic imprinting': differing expression between alleles inherited from mothers and...
- Is bariatric surgery a crime? A systematic review and meta-analysis of postoperative psychiatric symptoms and eating disordersby Bushra Albadareen on 25 Aprile 2025
Bariatric surgery can lead to significant weight loss and improved physical health. Still, it often also brings about complex psychological effects, including changes in self-esteem, body image and emotional well-being that require careful monitoring and support. This systematic review with meta-analysis aims to analyse the relationship between bariatric surgery and postoperative improvement in psychiatric and eating disorders. MEDLINE, EMBASE, COCHRANE Library and other specialized databases...
- Eating Disorders and Later Incidence of Cancer: A Nationwide Longitudinal Study in Denmarkby Gabrielle E Cooper on 25 Aprile 2025
CONCLUSIONS: All EDs were associated with a reduced incidence of breast cancer. All EDs except BN were associated with a higher incidence of respiratory and cervical cancers. AN was associated with a higher incidence of esophageal cancer.
- Neurobiology and Cognition in Girls at High-Risk of Eating Disorders: Exploring Imaging-Derived Trait Markersby E Pappaianni on 25 Aprile 2025
CONCLUSIONS: Girls at FHR show characteristic neurocognitive performance similar to that seen in individuals with ED, as well as differences in brain structure compared to HC. Our findings, together with previous evidence, highlight impairment in cognitive flexibility as a possible trait marker of ED. Further longitudinal studies are needed to confirm differences in GMV and CT identified in this study.
- Body Dysmorphia and Eating Disorders in Patients with Hidradenitis Suppurativaby Lauren M Ching on 25 Aprile 2025
No abstract
- Social Physique Anxiety in College Students: The Role of Study Field, Physical Activity, Physical Self-Perception, and Self-Esteemby Ioannis Tsartsapakis on 25 Aprile 2025
Young adults, especially students, face challenges that increase social anxiety, including Social Physique Anxiety (SPA). The objective of the present study was to examine SPA among college students across various study programs and explore its associations with exercise, physical self-perception, and self-esteem. A total of 465 students, with an average age of 21.3 years, completed the Social Physique Anxiety Scale, Rosenberg Self-Esteem Scale, and Physical Self-Perception Profile. Demographic...
- Melatonin supplementation: new insights into health and diseaseby Tatiana Palotta Minari on 25 Aprile 2025
CONCLUSION: Melatonin supplementation is not a universal solution but a potentially valuable tool in specific contexts. Its benefits are most evident in sleep regulation and certain neurodegenerative conditions. However, significant gaps in research, including inconsistent methodologies, small sample sizes, and limited data on long-term effects, necessitate further robust clinical trials. Individualized recommendations and cautious interpretation of findings are essential, particularly given the...
- Variation in Subtypes of Obsessive-Compulsive Traits in Migraine Patients Undergoing Onabotulinum Toxin A Therapyby Giovanna Viticchi on 25 Aprile 2025
CONCLUSIONS: Patients treated with OBT-A showed significant improvement in OCD, particularly in subscales assessing somatic and aggressive obsessions as well as control compulsions. Several patients transitioned from a CM + MOH condition to an episodic form without drug abuse. The potential impact of OBT-A on psychiatric symptoms warrants further consideration to improve patient management strategies.
- IQ and socio-occupational functioning in relation to obsessive-compulsive symptoms severity in a clinical sample of adolescentsby Riccardo Stefanelli on 24 Aprile 2025
Obsessive-compulsive disorder (OCD) is often comorbid with other psychiatric conditions, leading to severely impaired functioning and poor quality of life. Until now, the relationship between obsessive-compulsive symptoms (OCS) and functioning has been studied mainly through a categorical approach (i.e., presence/absence of the disorder), leaving more dimensional analyses almost unexplored. Therefore, the present study investigates the association between OCS and both intellectual functioning...
- Exploring OCD severity in treatment-seeking veterans: a cross-sectional comparison between post-traumatic stress disorder (PTSD) and complex-PTSD (C-PTSD)by Phoebe Howlett on 24 Aprile 2025
The recent International Classifications of Diseases-11 (ICD-11) distinction of complex- post-traumatic stress disorder (C-PTSD) from post-traumatic stress disorder (PTSD), has highlighted a research gap in exploring how C-PTSD may relate to obsessive-compulsive disorder (OCD) differently than PTSD. Mental health disorders and comorbidities appear to be greater in military veterans compared to the general population. Thus, this study aimed to explore potential differences in OCD severity between...
- Decoding vital variables in predicting different phases of suicide among young adults with childhood sexual abuse: a machine learning approachby Wenbang Niu on 24 Aprile 2025
Young adults with childhood sexual abuse (CSA) are an especially vulnerable group to suicide. Suicide encompasses different phases, but for CSA survivors the salient factors precipitating suicide are rarely studied. In this study, from a progressive perspective of suicidal thoughts and behaviors (STB), we aim to identify distinct risk factors for predicting different stages of STB, i.e., suicidal ideation (SI), suicide plan (SP), and suicide attempt (SA), among young adults with CSA experience....
- Intensive therapist guided self-help for treatment of OCD in a young girlby Mihika Shidore on 23 Aprile 2025
No abstract
- Efficacy and Safety of Transcranial Direct Current Stimulation (tDCS) in Patients with Obsessive-Compulsive Disorder (OCD): A Systematic Review and Meta-Analysis of Randomized Controlled Trialsby Reza Moshfeghinia on 23 Aprile 2025
CONCLUSIONS: This review suggests that tDCS may effectively alleviate OCD symptoms, along with related depression and anxiety, both acute and at follow-up, while causing minimal AEs.
- Posttraumatic stress in infancy: The roles of cumulative trauma and caregiving contextby Ann T Chu on 25 Aprile 2025
Infants are exposed to traumatic events at higher rates than older children, potentially leading to posttraumatic stress symptoms. Despite this higher prevalence, posttraumatic stress responses in infancy have not been well researched due to conceptual, developmental, and methodological challenges. This study conducted in the United States investigated the responses of infants aged 3-18 months after exposure to a range of traumatic events. Caregivers reported on their infants' trauma exposure...
- The Effect of Expressive Writing on Post-traumatic Stress Disorder and Hopelessness in Mothers with Premature Neonates Hospitalized in NICUby Behnaz Soltanpour on 25 Aprile 2025
CONCLUSIONS: Expressive writing proved effective in reducing PTSD and hopelessness in mothers with premature neonates. This low-cost and effective intervention is recommended for enhancing maternal mental health and empowering mothers for optimal care of premature infants in NICUs and after discharge.
- Treatment with psychedelics : potential benefits in Parkinson's diseaseby Louise Penzenstadler on 25 Aprile 2025
Psychedelics, such as psilocybin and lysergic acid diethylamide, modulate neuroplasticity and brain connectivity via 5-HT2A receptors. Their efficacy has been demonstrated in depression and anxiety, where they are particularly interesting because of their rapid and long-lasting effect. They could also be beneficial for addictions, post-traumatic stress, and obsessive-compulsive disorder. This article explores their therapeutic potential in Parkinson's disease (PD), both symptomatically in PD...
- Patient and health service factors associated with enrollment in a multidisciplinary pain rehabilitation program: a retrospective cohort studyby Michael A Bushey on 25 Aprile 2025
INTRODUCTION: Despite multidisciplinary pain rehabilitation programs (PRPs) being well-established as an effective treatment for chronic pain, the existence of such programs has been declining across the United States over recent decades.
- Sexual trauma and interest in mobile health among women with mental illness in Ghanaby Dror Ben-Zeev on 25 Aprile 2025
Sexual violence against vulnerable populations is common worldwide. Many survivors of sexual assault experience long-term mental health difficulties. This study evaluated sexual violence exposure among women with mental illness in Ghana and examined their readiness to engage in mobile health interventions. We surveyed 200 women receiving inpatient or outpatient treatment at a large psychiatric hospital. Survey results indicated that 41.0 % reported having experienced sexual violence in the past....
- A Quantitative Analysis of Work System Factors and Well-Being Among Nurses and Physicians in Rural and Urban Settings During Covid-19 Pandemicby Lukasz M Mazur on 25 Aprile 2025
BACKGROUND: The aim of this study was to assess work system factors and nurse and physician well-being across professionals (nurse vs. physician) and geographic locations (rural vs. urban) during COVID-19 pandemic.
- Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agentsby Fernanda M Q Silva on 5 Ottobre 2024
Fibromyalgia syndrome (FMS) is a chronic disorder characterized commonly by widespread musculoskeletal pain and fatigue, predominantly affecting women, with its complexity often leading to underdiagnosis and complicating treatment effectiveness. Transcranial magnetic stimulation (TMS) metrics are potential markers to optimize FMS treatments; however, evidence is limited. Our study aimed to explore the relationship between cortical excitability and inhibition, assessed through TMS markers, and...
- The Impact of Obesity as a Peripheral Disruptor of Brain Inhibitory Mechanisms in Fibromyalgia: A Cross-Sectional Studyby Walter Fabris-Moraes on 13 Luglio 2024
Background/Objective: Obesity, characterized by chronic inflammation, may serve as a surrogate marker for more dysfunctional peripheral inflammation, potentially exacerbating FM symptomatology. Given this premise, this study aimed to investigate the effects of obesity as an effect modifier on neural and clinical variables, specifically those indexing pain-compensatory mechanisms in FM symptoms. Methods: A cross-sectional study was conducted with 108 participants who underwent a standardized TMS...
- No add-on therapeutic benefit of at-home anodal tDCS of the primary motor cortex to mindfulness meditation in patients with fibromyalgiaby Perianen Ramasawmy on 20 Giugno 2024
CONCLUSIONS: Our findings demonstrate no synergistic or add-on efffect of anodal tDCS of the left M1 compared to the proper effect of MM in patients with fibromyalgia.
- Exercise effects on cortical excitability in pain populations: A systematic review and meta-analysisby Danielle Carolina Pimenta on 11 Giugno 2024
CONCLUSIONS: These findings suggest that exercise interventions positively affect pain relief by modifying corticospinal excitability, but their effects on ICI/ICF are still unclear. While the results are inconclusive, they provide a basis for further exploration in this area of research; future studies should focus on establishing standardized TMS measurements and exercise protocols to ensure consistent and reliable findings. A large-scale RCT that examines various exercise interventions and...
- Effect of neuronavigated repetitive Transcranial Magnetic Stimulation on pain, cognition and cortical excitability in fibromyalgia syndromeby Vikas Kumar Tiwari on 25 Gennaio 2024
CONCLUSIONS: Findings suggest that repetitive transcranial magnetic stimulation intervention is effective in managing pain alongside cognition and sleep disturbances in patients of fibromyalgia. It may prove to be an important tool in relieving fibromyalgia-associated morbidity.
- TMS in combination with a pain directed intervention for the treatment of fibromyalgia - A randomized, double-blind, sham-controlled trialby Einat Tilbor on 27 Dicembre 2023
CONCLUSION: Our results suggest that a course of dTMS combined with a pain-directed psychotherapeutic intervention can alleviate pain symptoms in FMS patients. Beyond clinical possibilities, future studies are needed to substantiate the innovative hypothesis that it is not dTMS alone, but rather dTMS-induced plasticity of pain-related networks, that enables the efficacy of pain-directed psychotherapeutic interventions.
- Effects of Combined Transcranial Magnetic Stimulation and Photobiomodulation in Mild Cognitive Impairment: A Randomized Controlled Trialby Da Han on 20 Aprile 2025
This study evaluates the synergistic effects of transcranial magnetic stimulation (TMS) and transcranial photobiomodulation (tPBM) on working memory (WM) in mild cognitive impairment (MCI) patients. In a randomized controlled trial with 88 participants, utilizing a complex WM task (ΔK = 6.41, p = 0.004) alongside functional near-infrared spectroscopy (fNIRS) to assess cognitive performance and neural correlates(neural metrics from fNIRS indicated enhanced functional connectivity [p = 0.015] and...
- Effects of 52 weeks of precuneus rTMS in Alzheimer's disease patients: a randomized trialby Giacomo Koch on 2 Aprile 2025
CONCLUSIONS: Fifty-two weeks of PC-rTMS may slow down the impairment of cognitive functions, activities of daily living and behavioral disturbances in patients with mild-to-moderate AD. Further multicenter studies are needed to confirm the clinical potential of DMN personalized rTMS.
- Development and evaluation of RhizoQOL, a quality-of-life caregiver-reported survey for rhizomelic chondrodysplasia punctata, a rare peroxisomal disorderby Mousumi Bose on 1 Aprile 2025
CONCLUSIONS: The final RhizoQOL survey instrument, consisting of 23 questions, assesses the symptoms and experiences of RCDP patients as observed by caregivers and serves as a novel clinical outcome assessment for RCDP therapeutic clinical trials to assess the impacts of RCDP and support the overall effectiveness of treatments.
- Gamma oscillation modulation for cognitive impairment: A systematic reviewby Emanuela Bartolini on 28 Marzo 2025
BackgroundGamma oscillation modulation has emerged as a potential non-invasive treatment to counteract cognitive impairment in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Non-invasive brain stimulation techniques like transcranial alternating current stimulation (tACS), gamma sensory stimulation (GSS), and transcranial magnetic stimulation (TMS) show promise in supporting specific cognitive functions.ObjectiveTo review and evaluate the efficacy of gamma oscillation modulation...
- A bibliometric analysis of research hotspots and trends in transcranial magnetic stimulation and Alzheimer's diseaseby Dingwen Xu on 14 Marzo 2025
CONCLUSION: Our article employs bibliometric methods to unveil trends in research related to AD and TMS, including collaborations among countries, regions, and authors, as well as key research hotspots. We provide objective data that serves as a reference for scientific research and clinical work concerning AD and TMS.
- Does Obstructive sleep apnea mediate the risk of cognitive impairment by expanding the perivascular space?by Shuan Ke on 14 Marzo 2025
CONCLUSIONS: We identified significant relations among OSA, EPVS, and CI. The AHI is a potential marker for estimating cognitive function in patients with EPVS.
- Cost-effectiveness of cognitive behavioural therapy versus health education for sleep disturbance and fatigue following stroke and traumatic brain injuryby Duncan Mortimer on 25 Aprile 2025
CONCLUSIONS: CBT-SF after acquired brain injury improved clinical and economic outcomes and was more likely to be cost-effective than HE. Further research is required to precisely estimate the cost-effectiveness of CBT-SF vs TAU and to demonstrate generalizability to routine practice and other settings. ANZCTR Trial registration numbers: 1261700087830; 12617000879369.
- Fetal-neonatal alloimmune thrombocytopenia: Mothers are affected tooby Eleanore A McFarland on 25 Aprile 2025
Fetal-neonatal alloimmune thrombocytopenia (FNAIT) results from parental platelet antigen incompatibility, with human platelet antigen (HPA)-1a the most common. Human leukocyte antigen (HLA)-DRB3*01:01 is strongly associated with the development of high titre anti-HPA-1a antibodies and B8DR3 with autoimmunity. Investigation of FNAIT has focused on fetal-neonatal haemorrhagic, placental and neurodevelopmental effects but has not included mothers. Symptomatic complaints pointing to autoimmunity...
- Examining the association between sleep apnea and total hippocampal volumes in cognitive impairmentby Matthew Settimi on 25 Aprile 2025
INTRODUCTION: The prevalence of dementia is rising due to an aging population. Given the known risks of obstructive sleep apnea (OSA) on cerebrovascular health, we hypothesized that markers of OSA would correlate with reduced hippocampal volumes in individuals with cognitive impairment due to neurodegenerative, vascular, or mixed (NVM) etiologies.
- Sleep Disturbances Associated with Different Systems of the Body: Underlying Mechanisms Involved and Consequencesby Haitham Yahya Al-Farsi on 25 Aprile 2025
Sleep is necessary for long-term health and well-being. Sleep is divided into the rapid eye movement (REM), and non-rapid eye movement (NREM) stages. The normal sleep pattern follows a 90-minute cycle, and within those cycles, the body undergoes a regenerative state, restoring various components used daily. A sleep disorder can be due to multiple factors, i.e., genetic, environmental, and individual factors. Short and long-term effects of sleep deprivation can have harmful effects. The immune...
- Insomnia increases the risk for specific autoimmune diseases: a large-scale retrospective cohort studyby Sarah Stenger on 25 Aprile 2025
CONCLUSION: This study highlights the integral role of sleep in maintaining immune homeostasis through multi-organ interactions involving the autonomic nervous system, immune signalling pathways, and endocrine regulation. Disruptions in these systems due to chronic sleep impairment may predispose individuals to autoimmune diseases by altering inflammatory responses and immune tolerance. These findings underscore the necessity of recognizing and treating sleep disorders not only for general...
- Wearable Sensors for Sleep Monitoring in Free-Living Environments: A Scoping Review on Parkinson's Diseaseby Joana Matos on 25 Aprile 2025
Parkinson's disease (PD) is a neurodegenerative disorder that affects multiple neural pathways, leading to a broad spectrum of motor and non-motor symptoms. Sleep disorders, such as insomnia and excessive daytime sleepiness, are prevalent among PD patients and significantly impact symptomatology and patients' quality of life. Wearable technology presents an opportunity to study these interactions in patients' daily life environments without the limitations of in-clinic sleep studies. Thus, this...
- Poly-symptomatology of chronic multi-canalicular benign paroxysmal positional vertigo: a deductive, inductive, and abductive narrative reviewby Carsten Tjell on 25 Aprile 2025
This narrative review aims to present an overview of the symptomatology of chronic multi-canalicular benign paroxysmal positional vertigo (mc-BPPV) from deductive (what is believed to be known), inductive (what is likely), and abductive (hypothetical) perspectives. The purpose is to recognize these symptoms as expressions of an eventual mc-BPPV when they occur in patients with vestibular migraine, whiplash associated disorders (WAD) and other chronic pain disorders. These symptoms are often...
- Evidence-based guidelines for the pharmacological treatment of migraineby Raffaele Ornello on 25 Aprile 2025
We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, actionable recommendations to healthcare professionals. They incorporate evidence-based recommendations from randomized controlled trials and expert-based opinions. The guidelines follow the Grading of Recommendations, Assessment, Development and Evaluation approach for...
- Fixed combination of palmitoylethanolamide and melatonin in preventive therapy of migraine: results from a randomized clinical trialby Vincenzo Piccolo on 25 Aprile 2025
CONCLUSION: These findings suggest that PEATONIDE^(®) may be a promising adjunctive approach for migraine management. However, given the relatively small sample size, further large-scale and multicenter trials are needed to confirm its clinical applicability in broader migraine population.
- Prevalence of Patent Foramen Ovale in Patients with Non-Obstructive Coronary Artery Disease (PROVA) Studyby Abdelhak El Bouziani on 25 Aprile 2025
(1) Background: Prevalence of patent foramen ovale (PFO) in the general population is estimated at around 24%. We hypothesized that right-to-left shunting (RLS) resulting from PFO might contribute to angina symptoms in patients with coronary artery spasm (CAS), potentially triggered by vasoactive metabolites. Therefore, the aim of this study was to investigate the prevalence of PFO-related RLS in patients with documented CAS. (2) Methods: This single-center prospective cohort study included...
- Evidence-based guidelines for the pharmacological treatment of migraine, summary versionby Raffaele Ornello on 25 Aprile 2025
We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, actionable recommendations to healthcare professionals. They incorporate evidence-based recommendations from randomized controlled trials and expert-based opinions. The guidelines follow the GRADE approach for assessing the quality of evidence. The guideline development...
- Brain Structural Abnormalities in Patients with Post-COVID-19 Headacheby Klaudia Széphelyi on 25 Aprile 2025
CONCLUSIONS: Persistent post-COVID-19 headaches may be linked to structural white matter changes observed in MRI. Further research, ideally including pre-infection imaging data, is needed to determine the causal relationship between these lesions and chronic headache symptoms.
- Is bariatric surgery a crime? A systematic review and meta-analysis of postoperative psychiatric symptoms and eating disordersby Bushra Albadareen on 25 Aprile 2025
Bariatric surgery can lead to significant weight loss and improved physical health. Still, it often also brings about complex psychological effects, including changes in self-esteem, body image and emotional well-being that require careful monitoring and support. This systematic review with meta-analysis aims to analyse the relationship between bariatric surgery and postoperative improvement in psychiatric and eating disorders. MEDLINE, EMBASE, COCHRANE Library and other specialized databases...
- Eating Disorders and Later Incidence of Cancer: A Nationwide Longitudinal Study in Denmarkby Gabrielle E Cooper on 25 Aprile 2025
CONCLUSIONS: All EDs were associated with a reduced incidence of breast cancer. All EDs except BN were associated with a higher incidence of respiratory and cervical cancers. AN was associated with a higher incidence of esophageal cancer.
- Neurobiology and Cognition in Girls at High-Risk of Eating Disorders: Exploring Imaging-Derived Trait Markersby E Pappaianni on 25 Aprile 2025
CONCLUSIONS: Girls at FHR show characteristic neurocognitive performance similar to that seen in individuals with ED, as well as differences in brain structure compared to HC. Our findings, together with previous evidence, highlight impairment in cognitive flexibility as a possible trait marker of ED. Further longitudinal studies are needed to confirm differences in GMV and CT identified in this study.
- Body Dysmorphia and Eating Disorders in Patients with Hidradenitis Suppurativaby Lauren M Ching on 25 Aprile 2025
No abstract
- Social Physique Anxiety in College Students: The Role of Study Field, Physical Activity, Physical Self-Perception, and Self-Esteemby Ioannis Tsartsapakis on 25 Aprile 2025
Young adults, especially students, face challenges that increase social anxiety, including Social Physique Anxiety (SPA). The objective of the present study was to examine SPA among college students across various study programs and explore its associations with exercise, physical self-perception, and self-esteem. A total of 465 students, with an average age of 21.3 years, completed the Social Physique Anxiety Scale, Rosenberg Self-Esteem Scale, and Physical Self-Perception Profile. Demographic...
- Melatonin supplementation: new insights into health and diseaseby Tatiana Palotta Minari on 25 Aprile 2025
CONCLUSION: Melatonin supplementation is not a universal solution but a potentially valuable tool in specific contexts. Its benefits are most evident in sleep regulation and certain neurodegenerative conditions. However, significant gaps in research, including inconsistent methodologies, small sample sizes, and limited data on long-term effects, necessitate further robust clinical trials. Individualized recommendations and cautious interpretation of findings are essential, particularly given the...
- S-9-PAHSA Attenuates Abeta Accumulation and Improves Cognitive Deficits by Promoting Mitochondrial Autophagy in 5xFAD Miceby Chenyu Lu on 25 Aprile 2025
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by significant cognitive impairment and predominantly affects the elderly. With no effective cure available, research continues to explore novel therapeutic and preventive strategies. Recently, palmitic acid-hydroxystearic acids (PAHSAs), especially their stereochemistry S-configuration, have shown potential as a dietary supplement with anti-inflammatory and anti-diabetic properties. We previously found that one of...
- Cost-effectiveness of cognitive behavioural therapy versus health education for sleep disturbance and fatigue following stroke and traumatic brain injuryby Duncan Mortimer on 25 Aprile 2025
CONCLUSIONS: CBT-SF after acquired brain injury improved clinical and economic outcomes and was more likely to be cost-effective than HE. Further research is required to precisely estimate the cost-effectiveness of CBT-SF vs TAU and to demonstrate generalizability to routine practice and other settings. ANZCTR Trial registration numbers: 1261700087830; 12617000879369.
- Investigation the therapeutic effect of mindfulness-based cognitive-behavioral counseling in pregnant women with body image dissatisfaction: A randomized controlled trialby Mehnoosh Farahabadi on 25 Aprile 2025
CONCLUSION: Mindfulness-based cognitive behavioral therapy can help reduce body image concerns in pregnant women. Therefore, it is recommended that mental health professionals utilize this approach to improve the psychological and physical well-being of pregnant women and assist them in modifying their attitudes towards body image.
- Cognitive behavioral therapy for ADHD predominantly inattentive presentation: randomized controlled trial of two psychological treatmentsby Elinor Eskilsson Strålin on 25 Aprile 2025
INTRODUCTION: Attention-Deficit Hyperactivity Disorder (ADHD) in adults is common and characterized by difficulties in regulation of attention, activity and goal directed behaviors. These challenges are especially associated with inattentive symptoms, why high levels of inattention imply severe impairment in everyday life. CBT for ADHD-inattentive presentation, (CADDI), is designed to treat inattention and incorporates skills training in organization, behavioral activation, and mindfulness. The...
- Exploring Fatigue in Parkinson's Disease: A Comprehensive Literature Reviewby Jamir Pitton Rissardo on 25 Aprile 2025
Fatigue is one of the most prevalent and debilitating non-motor symptoms of Parkinson's disease (PD), affecting up to two-thirds of patients and significantly impacting quality of life. This review provides a comprehensive analysis of its complex pathophysiology, prevalence, clinical presentation, assessment methods, and current management strategies. Fatigue in PD is linked to dysfunction in dopaminergic and non-dopaminergic pathways, neuroinflammation, genetic predispositions, and metabolic...
- Availability of Cognitive Remediation Therapy in United States Mental Health Facilities Serving Older Adults: A Statistical Studyby Tajudeen O Basiru on 25 Aprile 2025
CONCLUSION: This study highlights the relative unavailability of CRT, indicating a need for more interest in evidence-based nonpharmacological treatment options for cognitive decline in the aging population.
- Non-invasive brain stimulation for borderline personality disorder: a systematic review and network meta-analysisby Mohamed Ezzat M Mansour on 16 Aprile 2025
CONCLUSION: Preliminary evidence suggests potential efficacy of non-invasive brain stimulation for BPD, with well-tolerated side effects with well-tolerated side effects. Although there are noticeable statistically significant differences between the interventions and control groups, the results are inconclusive due to the small sample.
- Quetiapine and Paediatric Psychiatrica: Evidence or Diffidence?by Ahmed Naguy on 14 Aprile 2025
The atypical antipsychotic, quetiapine has been on market for years now with long track record. In child and adolescent psychiatry, it is FDA-approved for childhood-onset schizophrenia and juvenile bipolar mood disorder. Its attractive pharmacological portfolio speaks to the idea of a versatile pluripotent broad-spectrum psychotropic agent expanding its therapeutic potential on clinical grounds. In this focussed review, authors brief these clinical indications whilst examining the extant...
- Sequential Navigated Multilocus Repetitive Transcranial Magnetic Stimulation for Concurrent Somatic and Psychiatric Conditionsby Satu K Jääskeläinen on 14 Aprile 2025
CONCLUSIONS: Multilocus rTMS is an efficient tool for comorbid neurological and psychiatric disorders, with no serious adverse effects. Responder rate was rather high in patients with comorbidities, suggesting that rTMS efficacy may be associated with inherent patient-related factors.
- Unusual Stroke-Like Presentation of Tumefactive Multiple Sclerosis in a 27-Year-Old Manby Mohamed M Abd Elhamid on 2 Aprile 2025
Tumefactive multiple sclerosis (TMS) is a rare subtype of multiple sclerosis with diverse clinical presentations, often leading to delays in diagnosis and treatment initiation. On investigation, it presents with a large (>2 cm) demyelinating mass-like lesion and can be accompanied by ring enhancement, perilesional edema, and mass effect. We report the case of a 27-year-old man who presented with right-sided weakness and numbness. He had a similar presentation one year ago without a definitive...
- Evaluating the Safety Profile of Connectome-Based Repetitive Transcranial Magnetic Stimulationby Si Jie Tang on 21 Marzo 2025
CONCLUSION: These side effects were all transient and well-tolerated. No serious side effects were recorded. Results suggested that individualized, connectome-guided rTMS is safe and contain side effect profiles similar to other TMS approaches reported in the literature.
- A naturalistic analysis of rTMS treatment outcomes for major depressive disorder in West Australian youthby Aleksandra Miljevic on 19 Marzo 2025
CONCLUSIONS: The findings of this naturalistic report suggest that an acute course of rTMS is safe and effective - resulting in similar response rates in adolescent and youth patients as reported in adults. Future large-scale, randomized, and sham-controlled trials are needed to consolidate and add to these findings.
