AGGIORNAMENTO SCIENTIFICO IN TEMPO REALE FORNITO DA:
- Modulating Brain Excitability with Cardiovascular Exercise in Chronic Stroke: A Randomized Controlled Trialby Lynden Rodrigues on 10 Luglio 2025
CONCLUSIONS: Chronic CE increases excitatory ILH CSE measures and reduces interhemispheric imbalances but intensity does not have a moderating effect. More studies are needed to determine the functional relevance of exercise-induced changes in CSE in post-stroke recovery.
- Effect of augmentation with aripiprazole or augmentation with repetitive transcranial magnetic stimulation versus switching to the antidepressant venlafaxine extended release/duloxetine on cognition: A comparative effectiveness research trial for antidepressant incomplete and non-responders with treatment-resistant depression (ASCERTAIN-TRD)by Clotilde Guidetti on 9 Luglio 2025
Subjective cognitive impairment is a key symptom of major depressive disorder (MDD). Improvement of cognitive function in patients with treatment-resistant depression (TRD) is an important treatment outcome. This study compared the impact of augmenting antidepressants with aripiprazole or repetitive transcranial magnetic stimulation (rTMS) versus switching to venlafaxine (or duloxetine for those not eligible to receive venlafaxine) on cognition in TRD patients. In a pre-defined secondary...
- Subgenual anterior cingulate cortex functional connectivity abnormalities in depression: insights from brain imaging big data and precision-guided personalized intervention via transcranial magnetic stimulationby Xiao Chen on 8 Luglio 2025
The subgenual anterior cingulate cortex (sgACC) plays a central role in the pathophysiology of major depressive disorder (MDD). Its functional interactive profile with the left dorsal lateral prefrontal cortex (DLPFC) is associated with transcranial magnetic stimulation (TMS) treatment outcomes. Previous research on sgACC functional connectivity (FC) in MDD has yielded inconsistent results, partly due to small sample sizes and limited statistical power. Furthermore, calculating sgACC-FC to...
- Sensory Entrained TMS (seTMS) Enhances Motor Cortex Excitabilityby Jessica M Ross on 7 Luglio 2025
Transcranial magnetic stimulation (TMS) applied to the motor cortex has revolutionized the study of motor physiology in humans. Despite this, TMS-evoked electrophysiological responses show significant fluctuation, due in part to inconsistencies between TMS pulse timing and ongoing brain oscillations. Small or inconsistent responses to TMS limit mechanistic insights and clinical efficacy, necessitating the development of methods to precisely coordinate the timing of TMS pulses to the phase of...
- The impact of cannabis use on cortical excitability and inhibitory mechanisms: A case-control studyby Eman M Khedr on 5 Luglio 2025
Cannabis use has been linked to alterations in brain function, yet its effects on cortical excitability and inhibition remain unclear. This study aimed to assess the impact of cannabis use on cortical excitability, intracortical inhibition and sensory inhibition, and to examine whether changes correlate with clinical data. A total of 16 cannabis users and 20 controls were included in this study. Each was assessed with the following: Symptom checklist-90-Revised (SCL-90-R), Montreal cognitive...
- Cerebellar Brain Inhibition and Its Association with Motor Inhibition and Reaction Time In Younger and Older Adultsby Shanti Van Malderen on 4 Luglio 2025
Motor performance declines with age, particularly affecting reaction time and proactive response inhibition. While cortical influences on age-related motor decline are well-documented, the cerebellum's role remains unclear. Cerebellar Brain Inhibition (CBI), which can be measured through dual-site transcranial magnetic stimulation (TMS), may provide insights into age-related changes in motor control. We aimed to (1) compare resting-state CBI between young and older adults, (2) investigate the...
- Successful Ultrasound-Guided Dry Needling for Treatment of Piriformis Syndromeby Guntur Darmawan on 11 Luglio 2025
Piriformis syndrome is an often overlooked cause of chronic buttock or low back pain, sometimes radiating to the posterior thigh. Despite various treatment options, a definitive standard therapy has not been established. Dry needling has recently gained attention as a non-pharmacological intervention, especially when guided by ultrasound to enhance accuracy and safety. A 69-year-old woman presented with a 9-month history of fluctuating right gluteal pain, aggravated by prolonged sitting and...
- Costal Osteoid Osteoma: A Case Report and Review of the Literatureby Afnane Ismaili on 10 Luglio 2025
Costal osteoid osteoma is a rare benign tumor that can be diagnostically challenging due to its atypical location and nonspecific symptoms. We report the case of a 49-year-old male presenting with chronic right-sided chest wall pain for three years. Initial radiographs were normal, but CT imaging and bone scintigraphy later revealed a focal lesion on the ninth right rib. Surgical resection was performed, confirming the diagnosis histologically. The patient subsequently developed persistent...
- Spinal Mechanisms of Pain Modulation by Spinal Cord Stimulation: A Systematic Reviewby Jaden Y Fang on 10 Luglio 2025
Spinal cord stimulation (SCS) is a widely used neuromodulation therapy for chronic neuropathic pain, including failed back surgery syndrome and complex regional pain syndrome, but its mechanisms of action remain incompletely defined. This systematic review examined 40 unique preclinical animal studies to classify spinal mechanisms underlying SCS-induced analgesia. A comprehensive database search including PubMed, MEDLINE, and Cochrane was conducted through October 2024 following PRISMA...
- Objective, long-term mobility data in patients with chronic pain after lumbar spine surgery treated with spinal cord stimulation-a prospective, multicenter trialby Tobias Hallén on 10 Luglio 2025
CONCLUSION: The new objective data indicate that SCS has beneficial, long-term effects on mobility in patients with intractable leg pain after spine surgery.
- Principles for Chronic Pain Management in the Adult Traumatic Spinal Cord Injury Population at the Primary Healthcare Level, in a Developing Context: A Delphi Studyby Tammy-Lee Williams on 9 Luglio 2025
CONCLUSION: The agreed upon design principles may be considered as starting points for implementation at the primary health care level in the Western Cape of South Africa.
- Downregulation of Mfn2 Contributes to Chronic Postsurgical Pain via Inducing the Pyroptosis of GABAergic Neurons in the Spinal Cordby Yingjie Hu on 9 Luglio 2025
CONCLUSIONS: Our study demonstrated that downregulation of Mfn2 leads to mitochondrial dysfunction and ROS accumulation, which promotes the pyroptosis of spinal GABAergic neurons and the development of chronic pain.
- PTEN in somatostatin neurons regulates fear and anxiety and is required for inhibitory synaptic connectivity within central amygdalaby Timothy W Holford on 11 Luglio 2025
INTRODUCTION: The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a negative regulator of the mTOR pathway and is strongly associated with autism spectrum disorder (ASD), with up to 25% of ASD patients with macrocephaly harboring PTEN mutations. Mice with germline PTEN haploinsufficiency show behavioral characteristics resembling ASD, as do various mouse models with conditional knockouts of PTEN. Human tissue studies and those from multiple genetic mouse models suggest that...
- Exploring the psychological landscape of thyroid nodules: resilience, anxiety, and ultrasound correlationsby Jing Wang on 11 Luglio 2025
CONCLUSION: Higher C-TIRADS malignancy risk classifications were associated with reduced resilience and increased anxiety, particularly in patients with irregular nodule edges. Clinical approaches should focus on psychological support to boost resilience, treatment outcomes, and quality of life.
- The Effect of Social Problem-Solving Skills on Reducing Social Anxiety in Medical Studentsby Andi Tenri Pada Rustham on 11 Luglio 2025
CONCLUSION: Social problem-solving skill training gives a significant impact in reducing anxiety in first-year medical students.
- Stress to stability: Sense of coherence as a buffer against pandemic-related psychological distressby Anita Padmanabhanunni on 11 Luglio 2025
CONCLUSION: The findings emphasise the need for targeted approaches to strengthen SOC as a resilience-enhancing factor.
- Patient preference of integrated total pelvic floor ultrasound versus defaecatory proctographyby Esther Idowu on 11 Luglio 2025
CONCLUSION: More patients preferred total pelvic floor ultrasound due to less embarrassment, discomfort and the absence of oral contrast or rectal paste. This study offers insights into patient perspectives on pelvic floor investigations, serving as an important starting point for patient-centred clinical decision-making.
- Nursing Students' Perspectives on the Relationship between Virtual Reality Simulation and Clinical Decision-Making, Confidence, and Anxiety: A Cross-Sectional Studyby Hazem Alfanash on 11 Luglio 2025
CONCLUSIONS: While VR directly influences decision-making, it has a limited association with changes in nursing students' confidence and anxiety levels. These findings suggest that VR simulation alone may not be sufficient for enhancing confidence and reducing anxiety and should be integrated with other instructional strategies to maximize its effectiveness in nursing education. Future studies should explore complementary training methods to improve clinical preparedness.
- Emotions and Feelings as Predictors of Depression and Attention Deficit Hyperactivity Disorders among Children and Adolescents with Complete Blindnessby Marie Louise Nyirahabimana on 11 Luglio 2025
CONCLUSION: Interventions designed to elevate self-esteem and happiness as well as decrease anger, sadness, shame and guilt are needed for decreasing the risk of depression and ADHD.
- Four new Planothidium species (Achnanthidiaceae, Bacillariophyceae) from the Karst region of Guizhou in Chinaby Yun Li on 11 Luglio 2025
Four new species of monoraphid diatoms belonging to the genus Planothidium were studied and described from the karst region of Guizhou Province, China. The morphological characteristics of these new species were observed and documented using light and scanning electron microscopy. Planothidiumpseudoreichardtii sp. nov. exhibits a broad sinus at the central area on the interior of the rapheless valve, linear shallow depressions and a unique enlarged areola at the end of the striae on the exterior...
- Case report: Recurrent catatonia in a patient with 17p13.3 microduplication syndromeby Ilya Querter on 11 Luglio 2025
Catatonia is a clinically significant syndrome with various etiologies, including genetic factors, that are increasingly recognized. We present a case of recurrent catatonia associated with 17p13.3 microduplication syndrome in a 47-year-old woman with a long-standing history of recurrent depressive episodes. At age 44, she experienced her first episode with psychotic and catatonic features, which required hospitalization. Over the next three years, she had four additional catatonic episodes....
- Interventions for adolescent depression comorbid with non-suicidal self-injury: a scoping reviewby Shihan Fang on 11 Luglio 2025
CONCLUSIONS: Integrated biological-behavioral interventions, culturally tailored protocols, and family-system strategies are pivotal for managing NSSI-depression comorbidity. Future research should prioritize rigorous RCTs with extended follow-up periods, community-based implementation, and digital mental health solutions to address scalability and sustainability gaps.
- Association Between ECG Findings and Atherosclerotic Cardiovascular Disease (ASCVD) Risk Score: A Cross-Sectional Analysis of a Cohort Studyby Pouria Azami on 11 Luglio 2025
CONCLUSION: ST depression and LBBB show a modest association with cardiovascular risk stratification using the 10-year ASCVD risk score. Incorporating these ECG markers into clinical assessments may aid in identifying high-risk individuals, enabling more personalized interventions and refining cardiovascular risk prediction models.
- The Mediating Role of Humor in Relation With COVID-19 Fear, Anxiety and Depression of Bangladeshi People: A Cross-Sectional Studyby Md Shahinoor Rahman on 11 Luglio 2025
CONCLUSION: This finding indicated that a greater sense of humor leads to less anxiety and depression. In another way, a sense of humor could lessen COVID-19 fear and boost the mental health of the Bangladeshi people during this pandemic. This finding might help us understand that humor could be a protective and effective technique to fight pandemic fear. This study was only conducted in Bangladeshi culture who were literate and able to use the internet.
- Wernicke Encephalopathy Associated with Crohn's Diseaseby Marco Vidor on 11 Luglio 2025
Poorly controlled Crohn's disease is associated with several complications, including malabsorption of vitamins and minerals such as vitamin D, vitamin B12, and vitamin B1 (thiamine). Thiamine, among other vitamins, plays a crucial role in Adenosine Triphosphate formation as well as nerve propagation. Thiamine deficiency initially manifests as wet or dry beriberi but may lead to the devastating Wernicke-Korsakoff syndrome. In this report, we present a case of full-blown Wernicke encephalopathy...
- Global burden of alcoholic cardiomyopathy in middle-aged men (1990-2021) and projections to 2050: a systematic analysis of the Global Burden of Disease 2021 databy Yaqing Zhou on 11 Luglio 2025
CONCLUSION: ACM remains a major global health challenge, particularly in middle-aged males. Regional disparities highlight the need for targeted alcohol control policies and improved cardiovascular healthcare. Strengthened public health interventions are crucial to mitigating ACM-related mortality and disability.
- High-Dose Insulin Euglycemic Therapy in Concomitant Beta-Blocker and Calcium Channel Blocker Overdoseby Varun Roperia on 11 Luglio 2025
Beta-blockers and calcium channel blockers are among the most commonly used drugs in the adult population, and the National Poison Data System annual reports note 11 075 beta-blocker overdoses and 6256 calcium-channel blocker overdoses in 2022. Poisoning with these medications presents clinically with profound bradycardia, depression of myocyte contractility, and vasodilation resulting in hemodynamic instability often refractory to initial vasopressor treatment. Herein we present a case of...
- Whole-genome sequencing shows modulation of neurodegenerative genes by Withania somnifera in human SK-N-SH cellsby Eshita Sharma on 10 Luglio 2025
CONCLUSION: Taken together, our transcriptomic profiling study revealed for the first time that WS may modulate key genes in neurodegenerative disorders with potential beneficial implications for brain-related disorders and healthy aging.
- Co-design of the Australian Prompt Response Network for a public-health focused intersectoral approach to information sharing on emerging drugs of concernby Krista J Siefried on 10 Luglio 2025
The rapid emergence of new psychoactive substances (NPS) and other emerging drugs of concern presents a significant global public health challenge, necessitating agile and interconnected drug information systems to identify and communicate risks. In Australia, responses have traditionally been localized, lacking a nationally coordinated system to rapidly share information about emerging drug threats. The National Center for Clinical Research on Emerging Drugs (NCCRED) collaborated with...
- Correlation between religiosity, family functioning, and factors associated with substance use among secondary school students in high-risk areasby Noor Adnin Ab Aziz on 10 Luglio 2025
CONCLUSIONS: This study highlights the role of chaotic family dynamics and family satisfaction and its influence onto adolescent substance use. Despite the insignificant finding between religiosity and substance use, further exploration in this area is may prove beneficial to enhance care for individuals.
- Determination of kinetic characteristics of thermal desorption of cocaine by mass-spectrometric method of surface ionizationby Ganiboy T Rakhmanov on 11 Luglio 2025
The adsorption and surface ionization of cocaine molecules C(17)H(21)NO(4) (M: 303 Da) on the surface of oxidized tungsten was studied using the non-stationary voltage modulation method in a high-vacuum mass spectrometric setup employing a "black chamber," all the walls of which are cooled with liquid nitrogen. The activation energy Е^(+) and Е⁰ of thermal desorption were determined, as well as pre-exponential factors in the continuity equation for the radicals C(12)H(8)ON^(+) and C(12)H(8)ON...
- Cocaine-Induced Posterior Reversible Encephalopathy Syndrome (PRES): A Case Report Highlighting Neurological and Clinical Outcomesby Patricija Griškaitė on 11 Luglio 2025
CONCLUSIONS: Raising awareness of PRES and its less recognized but increasingly relevant risk factors, such as stimulant drug use - particularly cocaine - remains a critical aspect of improving diagnostic accuracy and management. Although PRES is typically reversible, delayed diagnosis and treatment may lead to permanent neurological complications, including cerebral infarction and hemorrhage.
- Efficacy and Safety of Glucagon-Like Peptide-1 Agonists for Psychiatric Symptoms: A Systematic Reviewby Shakila Meshkat on 10 Luglio 2025
CONCLUSION: GLP-1 RAs showed mixed and inconclusive effects on psychiatric symptoms. Although some studies suggested potential benefits, others reported null findings. Given the variability across trials, further research is needed to clarify their therapeutic potential.
- Differential Modulation of Glutamate Transporter-1 by Cocaine and Oxycodone and the Efficacy of MC-100093 to Reduce Reinstatement of Self-Administrationby Damyan W Hart on 10 Luglio 2025
CONCLUSIONS: Our results indicate that drug-specific reductions in NAc GLT-1 expression may be necessary for 093's efficacy. Further investigation into 093 and other opioids is needed to fully understand their relationship with GLT-1 expression and beta-lactams.
- Synergistic Drug-Induced Diffuse Alveolar Hemorrhage in a Polysubstance User: A Case of Inhaled Cocaine and Fentanyl Toxicityby Belissa A Lopez-Pena on 10 Luglio 2025
Diffuse alveolar hemorrhage (DAH) is a rare but life-threatening pulmonary condition characterized by bleeding into the alveolar spaces, most commonly associated with autoimmune or vasculitic disorders. However, drug-induced DAH, particularly from the inhalation of substances like cocaine and fentanyl, is an emerging concern. A 37-year-old homeless male with a history of intravenous and inhaled polysubstance abuse was found unresponsive and treated with intranasal naloxone for presumed opioid...
- Determinants of substance use among adolescents aged 10-19 years in Tanga Region, Eastern Tanzania: A cross-sectional analysisby Sanun Ally Kessy on 10 Luglio 2025
CONCLUSION: Substance use is common among the adolescent population in eastern Tanzania. Policies to keep adolescents in school are instrumental in reducing risk behaviours during adolescence. Targeted behaviour change interventions should be considered for older adolescents (15-19 years), out-of-school, males, and those exposed to sexual activities.
- Beyond the Bet: Exploring Gambling Disorder and Its Comorbidities: Case Seriesby R Selvameenatchi on 11 Luglio 2025
No abstract
- Is a History of Gestational Diabetes Associated With Long-Term Mental Health?-Findings From the GEMS 5-Year Follow Up Studyby Phyllis Ohene-Agyei on 10 Luglio 2025
CONCLUSION: The risk of poor mental health is common five years after birth. However, GDM diagnosis was not associated with an increased risk for anxiety or depression, although GDM may affect women's perception of their later general health and social functioning.
- Metformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocolby Silke Gillessen on 10 Luglio 2025
BACKGROUND: Metformin is a widely used anti-diabetic drug. Several studies have suggested that metformin has anticancer activity in some malignancies, including prostate cancer. Metformin might also mitigate the adverse metabolic effects of androgen-deprivation therapy (ADT). We hypothesised that metformin might improve survival in patients with metastatic hormone-sensitive prostate cancer and reduce metabolic complications associated with ADT.
- Multi-task machine learning reveals the functional neuroanatomy fingerprint of mental processingby Zifan Wang on 9 Luglio 2025
Mental processing delineates the functions of human mind encompassing a wide range of motor, sensory, emotional, and cognitive processes, each of which is underlain by the neuroanatomical substrates. Identifying accurate representation of functional neuroanatomy substrates of mental processing could inform understanding of its neural mechanism. The challenge is that it is unclear whether a specific mental process possesses a 'functional neuroanatomy fingerprint', i.e., a unique and reliable...
- Treatment of Gaming Disorder in Children and Adolescents: A Systematic Reviewby Jennifer J Park on 9 Luglio 2025
CONCLUSION: Although research on the treatment of GD in children and adolescents has grown, it remains in its early stages. To advance evidence-based treatment, future research should prioritize methodologically rigorous designs, standardized outcome measures, and long-term follow-up assessments.
- The Relationships of Early Use of Marijuana With Substance Use and Violence in Adolescent Gamblers and Non-Gamblersby Greta Sirek on 9 Luglio 2025
CONCLUSION: Early MU is associated with risky behaviors involving the use of other substances and violence, and its relationships with several factors differ according to gambling status. Reducing early engagement in addictive behaviors may be important for preventions against substance use disorders and interpersonal violence.
- Associations Between the Use of Fitness and Diet Tracking Technology and Disordered Eating Behaviour: A Systematic Reviewby Sarah Moody on 11 Luglio 2025
CONCLUSION: While fitness and diet tracker use is a correlate of disordered eating, it is currently not possible to conclude if they increase disordered eating, or the direction of this relationship. Future research should determine the nature of this relationship and possible mechanisms to ensure their safe use in vulnerable populations.
- Do we need novel treatments for anorexia nervosa? A patient perspectiveby James Downs on 11 Luglio 2025
Despite growing interest in novel treatments for anorexia nervosa, outcomes remain poor - often not because existing interventions are inherently ineffective, but due to systemic barriers that hinder their delivery. Written by a person with lived experience, this article critiques the prioritisation of innovation over implementation, highlighting how funding structures, methodological limitations and ethical practices in research can exacerbate inequalities and constrain real-world impact. It...
- Exploring the Interplay Between Thyroid Hormone Levels and Symptoms of Anxiety and Depression in Anorexia Nervosaby Lama Mattar on 11 Luglio 2025
CONCLUSION: A high prevalence of these symptoms among malnourished individuals requires investigation to differentiate between symptoms directly related to the biological effects of malnutrition and those indicative of a comorbid condition such as depression or anxiety.
- Vitamin C Deficiency in a 24-Year-Old Male Resulting in Anemia From Hematuria and Impaired Erythropoiesis Requiring Multiple Transfusionsby Vinh Dao on 11 Luglio 2025
Vitamin C deficiency, or scurvy, is an often-overlooked nutritional disorder in modern clinical practice, particularly in high-income countries, such as the United States. It is most commonly associated with food insecurity, poverty, and generalized malnutrition. However, this case underscores an equally important yet less recognized risk factor: autism spectrum disorder (ASD). Individuals with ASD are at high risk given their sensory sensitivities and food selectivity, and frequently exhibit...
- A Narrative Inquiry Into Problematic Internet Use Among Young Adults: A Narrative Reviewby Alan D Kaye on 11 Luglio 2025
The inescapable influence of the internet and social media has fundamentally transformed human interaction and behavior, leading to a profound digital dependency in a constantly connected contemporary society. This narrative review explores the surge in internet and social media usage globally, driven by the proliferation of new applications and the ubiquity of smart devices. The evolving landscape of digital platforms, exemplified by the rise of TikTok and the multifunctionality of apps like...
- The Association of Healthy Eating Index and Sleep Disorders: A Meta-Analysisby Wei Guo on 10 Luglio 2025
CONCLUSION: The higher HEI score is associated with good sleep quality and a reduced risk of abnormal sleep time.
- Exploring the Interplay Between Thyroid Hormone Levels and Symptoms of Anxiety and Depression in Anorexia Nervosaby Lama Mattar on 11 Luglio 2025
CONCLUSION: A high prevalence of these symptoms among malnourished individuals requires investigation to differentiate between symptoms directly related to the biological effects of malnutrition and those indicative of a comorbid condition such as depression or anxiety.
- Inhibitory Learning-based Exposure Response Prevention Therapy in Obsessive-compulsive Disorder: A Development and Efficacy Trial Protocolby Mareena Thampy on 11 Luglio 2025
BACKGROUND: Serotonin reuptake inhibitors (SSRIS) and cognitive behavior therapy (CBT), comprising exposure and response prevention (ERP), are the first line of treatment for obsessive compulsive disorders (OCD). However, many patients fail to achieve clinically significant symptom relief from traditional exposure-based therapies. This has led to research on strategies that can optimize the effects of ERP. Inhibitory learning theory (ILT) provides a novel foundation for understanding how...
- Classification of hoarding and comorbid neuropsychiatric symptomsby Sara K Nutley on 11 Luglio 2025
CONCLUSIONS: Neuropsychiatric symptom patterns among individuals with hoarding are heterogenous in nature and uniquely associated with clinical features and functional outcomes. These findings may inform the development of targeted interventions for HD that include assessment and management of depressive symptoms, inattention, and memory.
- Can mindfulness-based EX/RP improve comorbid OCD-MDD treatment in South Asian mental health settings?by Mohammad Asif Sheikh on 11 Luglio 2025
No abstract
- Quality of Life and Prevalence of Impulsivity in Females With Migraine Headachesby Mariwan Husni on 10 Luglio 2025
Background Migraine is a common neurological disorder with significant socioeconomic and personal impact. Recent research suggests a potential association between migraine and impulsivity, particularly in females. Objective This study aims to investigate the prevalence of impulsivity and its correlation with migraine-related disability in females with migraine. Methods This is a case-control study involving female patients aged 18-60 with migraine, recruited from neurology and psychiatry...
- Unveiling anomalies in visual processing regions in obsessive-compulsive disorder: evidence from gray matter volume and functional connectivity analysesby Rui Liu on 10 Luglio 2025
Obsessive-compulsive disorder (OCD) is a prevalent neurological condition characterized by recurring obsessive thoughts and compulsive behaviors. The underlying mechanisms of the disorder remain poorly understood due to its considerable heterogeneity. Given the extensive brain impairments observed in OCD, this study aimed to investigate gray matter volume and functional connectivity in individuals with OCD using a multimodal neuroimaging approach, while also exploring the relationship between...
- Psychiatric screening tools in asthma and their barriers to clinical utilization: a systematic reviewby Snigdha Widge on 11 Luglio 2025
CONCLUSION: Considering multiple factors such as ease of administration, effectiveness, and cost, we recommend a combination of PHQ-9, GAD-7, and PCL-5 as screening tools for psychiatric comorbidity in primary care and specialty clinics managing adult asthma. Two of these tools are available in EMRs within Alberta.
- Sex-specific effects of predator scent stress on fear, anxiety-like behavior and methamphetamine seeking in ratsby Modrak Cg on 11 Luglio 2025
Methamphetamine use disorder (MUD) is frequently comorbid with other disorders, such as post-traumatic stress disorder (PTSD). Here, we used a rat model of PTSD+MUD to evaluate the influence of sex and stress on methamphetamine-seeking and on the activation of frontocortical regions during reinstatement of meth-seeking. Male and female Sprague-Dawley rats were exposed to predator scent stress (PSS) or a control odor for 10 min, followed by anxiety testing one week later. Rats were re-exposed to...
- Acute Self-Harm Ideation as Presenting Adverse Event Associated with Adalimumab Treatment of Severe Scalp Psoriasisby Julian Cortes on 11 Luglio 2025
We report a 34-year-old woman with severe scalp psoriasis presented to a dermatology clinic in San Diego, USA, in 2023. She developed acute self-harm ideations and major depressive symptoms shortly after initiating adalimumab treatment. The patient had a history of major depressive disorder, post-traumatic stress disorder and anxiety, all well-controlled with multiple medications. Following the administration of adalimumab, she experienced intrusive thoughts of self-harm and exacerbation of...
- Psychological wellbeing of Ukrainian civilians: a data report on the impact of traumatic events on mental healthby Anton Kurapov on 11 Luglio 2025
No abstract
- Editorial: Sexual violence in times of conflictby Thomas Wenzel on 11 Luglio 2025
No abstract
- How the body tells the story: using the nonverbal cues of trauma between mothers and toddlers to mark a change in maternal attitudes during Clinician-Assisted Videofeedback Exposure Sessionsby Suzi Tortora on 10 Luglio 2025
INTRODUCTION: This study aims to examine what a form of video-based analysis of nonverbal communication: "Dyadic Attachment-based Nonverbal Communicative Expressions (DANCE)" can reveal about change in the bodies of interpersonal violence-exposed mothers who suffer from posttraumatic stress disorder. DANCE, developed by a dance-movement therapist (first author) was applied to video excerpts from a videofeedback, exposure- and mentalization-based, manualized intervention. This intervention,...
- Guidelines on Treating Fibromyalgia With Nonpharmacological Therapies in Chinaby Xuanlin Li on 11 Giugno 2025
Fibromyalgia is a prevalent chronic condition marked by widespread pain, fatigue, and other debilitating symptoms. This guideline provides evidence-based recommendations for nonpharmacological treatments, developed by a multidisciplinary expert group, including specialists in rheumatology, rehabilitation, pain management, traditional Chinese medicine (TCM), and evidence-based medicine. The guideline follows the RIGHT checklist and is registered with the International Practice Guideline Registry...
- Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agentsby Fernanda M Q Silva on 5 Ottobre 2024
Fibromyalgia syndrome (FMS) is a chronic disorder characterized commonly by widespread musculoskeletal pain and fatigue, predominantly affecting women, with its complexity often leading to underdiagnosis and complicating treatment effectiveness. Transcranial magnetic stimulation (TMS) metrics are potential markers to optimize FMS treatments; however, evidence is limited. Our study aimed to explore the relationship between cortical excitability and inhibition, assessed through TMS markers, and...
- The Impact of Obesity as a Peripheral Disruptor of Brain Inhibitory Mechanisms in Fibromyalgia: A Cross-Sectional Studyby Walter Fabris-Moraes on 13 Luglio 2024
Background/Objective: Obesity, characterized by chronic inflammation, may serve as a surrogate marker for more dysfunctional peripheral inflammation, potentially exacerbating FM symptomatology. Given this premise, this study aimed to investigate the effects of obesity as an effect modifier on neural and clinical variables, specifically those indexing pain-compensatory mechanisms in FM symptoms. Methods: A cross-sectional study was conducted with 108 participants who underwent a standardized TMS...
- No add-on therapeutic benefit of at-home anodal tDCS of the primary motor cortex to mindfulness meditation in patients with fibromyalgiaby Perianen Ramasawmy on 20 Giugno 2024
CONCLUSIONS: Our findings demonstrate no synergistic or add-on efffect of anodal tDCS of the left M1 compared to the proper effect of MM in patients with fibromyalgia.
- Exercise effects on cortical excitability in pain populations: A systematic review and meta-analysisby Danielle Carolina Pimenta on 11 Giugno 2024
CONCLUSIONS: These findings suggest that exercise interventions positively affect pain relief by modifying corticospinal excitability, but their effects on ICI/ICF are still unclear. While the results are inconclusive, they provide a basis for further exploration in this area of research; future studies should focus on establishing standardized TMS measurements and exercise protocols to ensure consistent and reliable findings. A large-scale RCT that examines various exercise interventions and...
- Effect of neuronavigated repetitive Transcranial Magnetic Stimulation on pain, cognition and cortical excitability in fibromyalgia syndromeby Vikas Kumar Tiwari on 25 Gennaio 2024
CONCLUSIONS: Findings suggest that repetitive transcranial magnetic stimulation intervention is effective in managing pain alongside cognition and sleep disturbances in patients of fibromyalgia. It may prove to be an important tool in relieving fibromyalgia-associated morbidity.
- Mapping cerebellar connectivity to cognition in psychosis: Convergent evidence from fMRI and TMSby Hengyi Cao on 5 Luglio 2025
CONCLUSIONS: These findings suggest a potential causal pathway from cerebellar connectivity to domain-specific cognitive deficits and psychopathology in schizophrenia. Moreover, they also point to the cerebellum as a potential target for the treatment of cognitive dysfunction in psychotic disorders.
- Foot-Tapping fMRI-Guided rTMS Enhances Motor and Cognitive Functions in Parkinson's Disease: A Three-Year Follow-Upby Zhiyi Hong on 28 Giugno 2025
No abstract
- Effect of transcranial magnetic stimulation on perioperative neurocognitive dysfunction: study protocol for a systematic review and meta-analysis of randomised controlled trialsby Jiarong Zeng on 24 Giugno 2025
INTRODUCTION: Perioperative neurocognitive disorders (PNDs), a common postoperative complication associated with anaesthesia and surgical procedures, are characterised by impairments in memory, attention, language comprehension and social functioning. Accumulating evidence from clinical studies indicates that transcranial magnetic stimulation (TMS)-a non-invasive neuromodulatory modality capable of targeted cortical stimulation-may offer therapeutic promise for PND management. To comprehensively...
- In vivo assessment of GABAergic inhibition and glutamate facilitation in treatment-resistant schizophrenia: a TMS study integrating clinical, cognitive, and neurophysiological evaluationsby Annarita Barone on 19 Giugno 2025
Treatment-resistant schizophrenia (TRS) affects approximately one-third of individuals with schizophrenia, posing significant challenges for clinical management. Clozapine treatment is often delayed, underscoring the urgent need for an early potential signature of TRS. To date, specific alterations in cortical excitability and plasticity underlying TRS remain unexplored. We evaluated cortical excitability and plasticity in 30 patients with schizophrenia (15 TRS, 15 non-TRS) and 21 controls using...
- Effect of transcranial magnetic stimulation combined with transcutaneous auricular vagus nerve stimulation on mild cognitive impairment: a study protocol for a randomized controlled trialby Jingjing Zhang on 16 Giugno 2025
BACKGROUND: Non-invasive brain stimulation techniques have been widely used in patients with mild cognitive impairment (MCI) to accelerate the recovery of their cognitive functions. However, the clinical efficacy of single non-invasive stimulation techniques in treating MCI still requires further improvement. The combination of two non-invasive neuromodulation techniques can enhance the synergistic effects of the treatment. Repetitive transcranial magnetic stimulation (rTMS) regulates the...
- Network-targeted transcranial magnetic stimulation (TMS) for mild cognitive impairment (MCI)by Joy L Taylor on 13 Giugno 2025
CONCLUSION: These results can be applied to network-targeted brain stimulation for MCI and early AD treatment. Greater precision and personalization of TMS offer the promise of achieving better outcomes for individuals with MCI or mild AD dementia.
- Cognitive Performance in Early Neuronal Synuclein Disease with Hyposmia but without Motor Disability: Association with Dopamine Deficiency and Isolated Rapid Eye Movement Sleep Behavior Disorderby Daniel Weintraub on 11 Luglio 2025
OBJECTIVE: To determine the impact of dopamine deficiency and isolated rapid eye movement (REM) sleep behavior disorder (iRBD) on cognitive performance in early neuronal α-synuclein disease (NSD) with hyposmia but without motor disability.
- Prevalence, Factors and Impact of Migraine on Healthcare Professionals: A cross-sectional study in the United Arab Emiratesby Syyeda Maleha Jeelani on 11 Luglio 2025
CONCLUSIONS: Approximately 1 in 5 HCPs in the UAE experience migraines. Several personal and modifiable factors contribute to an increased risk of migraines, which significantly impair QoL, work performance and disability levels.
- Neuropsychiatric Manifestations of Lyme Disease: A Literature Review of Psychiatric and Cognitive Impactsby Gabija Šegždaitė on 11 Luglio 2025
CONCLUSIONS: There is no strong evidence supporting Lyme disease's role in long-term cognitive or psychiatric disorders. However, an early diagnosis and timely antibiotic treatment remain crucial in minimizing long-term consequences and improving patient outcomes.
- Circadian timing and entrainment properties of the SCN pacemaker in the PS19 mouse model of tau pathologyby Nicklaus R Halloy on 11 Luglio 2025
Tauopathies are a group of neurodegenerative disorders caused by the misfolded microtubule-associated protein tau (MAPT), leading to its abnormal accumulation and hyperphosphorylation, and resulting in neuronal dysfunction and death. Tauopathy patients also experience disruptions to circadian rhythms of behavior and sleep. The connection between tau pathology and circadian dysfunction is not well understood, especially regarding the role of the suprachiasmatic nucleus (SCN), the brain's central...
- Clinical Features of Migraine, Vestibular Migraine, and Tension-Type Headache and Their Vestibular Evoked Myogenic Potential Studyby Ai Juan Zhang on 11 Luglio 2025
CONCLUSIONS: Psychiatric comorbidities were most pronounced in TTH, followed by VM and migraine. Both VM and TTH were associated with transient vertigo, exposing patients to drop-attack risk. The significantly higher occipital and/or neck pain reported in VM than in migraine may suggest the cervical neurovascular involvement in its pathophysiology. VEMP results indicate peripheral vestibular dysfunctions in VM patients and lower brainstem involvement in both VM and migraine patients, with the...
- Burnout Syndrome and Sexual Disorders Among Vietnamese Female Nurses and Midwives at Tu Du Hospital: A Frontline Hospital-Based Cross-Sectional Studyby Thanh Hai Pham on 11 Luglio 2025
CONCLUSION: Overall, the prevalence of burnout and sexual disorders were 27.0% and 12.0%, respectively. Importantly, work-related factors were the main factors associated with burnout syndrome. EE and reduced PA were related to sexual disorders. These results underscore the need to assess support for the professional well-being of nurses and midwives. Further national-database studies are required to strengthen these findings.
- Dissecting Causal Relationships Between Gut Microbiota, Immunocyte Phenotype, and Migraine: A Mendelian Randomization Studyby Yupei Lai on 11 Luglio 2025
CONCLUSIONS: This study provides robust evidence of a causal relationship between Bifidobacteriaceae and a decreased risk of migraine. Furthermore, we identify HLA-DR on monocytes as a key inflammatory mediator in the protective effect of Prevotella against migraine with aura. These findings highlight the potential of gut microbiota modulation and immune-targeted therapies in migraine prevention and treatment, offering novel insights into the gut-brain-immune axis in migraine pathogenesis.
- Prevalence, Factors and Impact of Migraine on Healthcare Professionals: A cross-sectional study in the United Arab Emiratesby Syyeda Maleha Jeelani on 11 Luglio 2025
CONCLUSIONS: Approximately 1 in 5 HCPs in the UAE experience migraines. Several personal and modifiable factors contribute to an increased risk of migraines, which significantly impair QoL, work performance and disability levels.
- The Role of Inflammation in Migraine Headaches: A Reviewby Caryn T Morgan on 11 Luglio 2025
Migraine is a chronic pulsating primary headache affecting billions of individuals worldwide. The condition is associated with neuroinflammation and is listed as the second most common form of headache disorders and the leading cause of disabilities. Migraineurs are susceptible to various pathological conditions ranging from mood and emotional dysregulation to neuronal disorders. Consequently, they often experience a higher rate of depression compared to non-migraineurs. Some migraineurs do not...
- Clinical Features of Migraine, Vestibular Migraine, and Tension-Type Headache and Their Vestibular Evoked Myogenic Potential Studyby Ai Juan Zhang on 11 Luglio 2025
CONCLUSIONS: Psychiatric comorbidities were most pronounced in TTH, followed by VM and migraine. Both VM and TTH were associated with transient vertigo, exposing patients to drop-attack risk. The significantly higher occipital and/or neck pain reported in VM than in migraine may suggest the cervical neurovascular involvement in its pathophysiology. VEMP results indicate peripheral vestibular dysfunctions in VM patients and lower brainstem involvement in both VM and migraine patients, with the...
- Acmella oleracea and Boswellia serrata for Symptom Relief and Reduced Analgesic Use in Women with Dysmenorrheaby Maria Teresa Schettino on 11 Luglio 2025
CONCLUSIONS: These preliminary findings suggest that this food supplement may effectively reduce dysmenorrhea symptoms and reliance on NSAIDs in patients with insufficient response to conventional therapies. Further validation through randomized controlled trials is needed to confirm these results and establish the supplement's role in dysmenorrhea management.
- Unraveling the Threads: A Case Report on Confusional Migraine and the Intricate Dance Between Psychiatry and Neurologyby Mabit C Gonzalez on 11 Luglio 2025
CONCLUSION: Our patient's presentation is suggestive of acute confusional migraine, which poses several diagnostic complexities and illustrates the difficulties with symptomatology that might have a medical/organic component versus a psychiatric one. The literature on this topic is lacking, and further research into this condition is warranted to optimize comprehensive patient care.
- Associations Between the Use of Fitness and Diet Tracking Technology and Disordered Eating Behaviour: A Systematic Reviewby Sarah Moody on 11 Luglio 2025
CONCLUSION: While fitness and diet tracker use is a correlate of disordered eating, it is currently not possible to conclude if they increase disordered eating, or the direction of this relationship. Future research should determine the nature of this relationship and possible mechanisms to ensure their safe use in vulnerable populations.
- Do we need novel treatments for anorexia nervosa? A patient perspectiveby James Downs on 11 Luglio 2025
Despite growing interest in novel treatments for anorexia nervosa, outcomes remain poor - often not because existing interventions are inherently ineffective, but due to systemic barriers that hinder their delivery. Written by a person with lived experience, this article critiques the prioritisation of innovation over implementation, highlighting how funding structures, methodological limitations and ethical practices in research can exacerbate inequalities and constrain real-world impact. It...
- Exploring the Interplay Between Thyroid Hormone Levels and Symptoms of Anxiety and Depression in Anorexia Nervosaby Lama Mattar on 11 Luglio 2025
CONCLUSION: A high prevalence of these symptoms among malnourished individuals requires investigation to differentiate between symptoms directly related to the biological effects of malnutrition and those indicative of a comorbid condition such as depression or anxiety.
- Vitamin C Deficiency in a 24-Year-Old Male Resulting in Anemia From Hematuria and Impaired Erythropoiesis Requiring Multiple Transfusionsby Vinh Dao on 11 Luglio 2025
Vitamin C deficiency, or scurvy, is an often-overlooked nutritional disorder in modern clinical practice, particularly in high-income countries, such as the United States. It is most commonly associated with food insecurity, poverty, and generalized malnutrition. However, this case underscores an equally important yet less recognized risk factor: autism spectrum disorder (ASD). Individuals with ASD are at high risk given their sensory sensitivities and food selectivity, and frequently exhibit...
- A Narrative Inquiry Into Problematic Internet Use Among Young Adults: A Narrative Reviewby Alan D Kaye on 11 Luglio 2025
The inescapable influence of the internet and social media has fundamentally transformed human interaction and behavior, leading to a profound digital dependency in a constantly connected contemporary society. This narrative review explores the surge in internet and social media usage globally, driven by the proliferation of new applications and the ubiquity of smart devices. The evolving landscape of digital platforms, exemplified by the rise of TikTok and the multifunctionality of apps like...
- The Association of Healthy Eating Index and Sleep Disorders: A Meta-Analysisby Wei Guo on 10 Luglio 2025
CONCLUSION: The higher HEI score is associated with good sleep quality and a reduced risk of abnormal sleep time.
- Inhibitory Learning-based Exposure Response Prevention Therapy in Obsessive-compulsive Disorder: A Development and Efficacy Trial Protocolby Mareena Thampy on 11 Luglio 2025
BACKGROUND: Serotonin reuptake inhibitors (SSRIS) and cognitive behavior therapy (CBT), comprising exposure and response prevention (ERP), are the first line of treatment for obsessive compulsive disorders (OCD). However, many patients fail to achieve clinically significant symptom relief from traditional exposure-based therapies. This has led to research on strategies that can optimize the effects of ERP. Inhibitory learning theory (ILT) provides a novel foundation for understanding how...
- Sine of the times: Can sinusoidal waves model changes in the therapeutic alliance over time?by Jonathan G Shalom on 11 Luglio 2025
The present study examined the association between the therapeutic alliance and social anxiety symptoms during internet-delivered cognitive behavior therapy (ICBT) for social anxiety disorder (SAD). We examined 162 individuals diagnosed with SAD who underwent therapist-assisted ICBT and completed measures of the therapeutic alliance weekly during a randomized controlled trial. We used a novel modeling strategy and modeled changes in the therapeutic alliance over time using sinusoidal models. We...
- Correction: The effects of cognitive behavioral therapy-based digital therapeutic intervention on patients with alcohol use disorderby Song-Hee Lim on 11 Luglio 2025
[This corrects the article DOI: 10.3389/fpsyt.2025.1486338.].
- Exploring mental health professionals' emotional responses with individuals diagnosed with antisocial personality disorder or psychopathy: a scoping reviewby Gabriele Lo Buglio on 10 Luglio 2025
CONCLUSION: Individuals with antisocial and psychopathy traits or disorders pose significant challenges in terms of clinicians' emotional responses, highlighting the need for tailored training and supervision to enhance their competence and confidence. The absence of cohort studies and randomized controlled trials on this subject, along with the limited evidence on psychopathy, warrants for further research.
- Harnessing Artificial Intelligence in Lifestyle Medicine: Opportunities, Challenges, and Future Directionsby Diana K Saeed on 10 Luglio 2025
Lifestyle medicine (LM) offers a transformative, evidence-based approach to preventing, managing, and potentially reversing chronic diseases by targeting modifiable lifestyle factors such as nutrition, physical activity, sleep, stress, substance use, and social connectivity. However, real-world implementation of LM is often hindered by patient adherence issues, limited clinical time, and the need for ongoing personalized support. Artificial intelligence (AI), with its capabilities in data...
- Applying a mobile intervention for chronic insomnia in routine care: Study protocol for a multicenter randomized controlled trialby Daa Un Moon on 10 Luglio 2025
Cognitive behavioral therapy for insomnia (CBT-I) is the first-line treatment for chronic insomnia. However, access to in-person CBT-I remains limited due to a shortage of trained providers and structural barriers. Digital CBT-I (dCBT-I) offers a scalable solution to bridge this treatment gap, yet real-world evidence of its effectiveness remains limited. This study aims to examine the effectiveness of a mobile dCBT-I intervention, "SleepQ," in a routine clinical setting. This study is a...
- Intranasal administration of temozolomide conjugated nanoparticles with transcranial magnetic stimulation improves the survival in glioblastoma xenograft modelsby Matthew Koh on 7 Luglio 2025
Glioblastoma Multiforme (GBM) is the most common primary malignancy of the central nervous system with an average survival time of 15 months following standard therapy. Furthermore, since its clinical introduction in 1999, temozolomide (TMZ) remains the chief therapeutic agent for GBM to date. However, because TMZ is administered orally, the blood-brain barrier (BBB) poses a significant challenge in GBM treatment, with efforts to overcome it complicated by unsustainable immunosuppression side...
- Efficacy evaluation of allergen-specific immunotherapy in children with asthma: a systematic review and meta-analysisby Kangping Wu on 3 Luglio 2025
CONCLUSION: Allergen-specific immunotherapy showed a positive effect in improving the symptoms of childhood asthma and reducing the need for medication, but there was significant heterogeneity among different studies. More high-quality RCTs are needed in the future to further explore the safety and long-term efficacy of immunotherapy to optimize its application in the management of childhood asthma.
- Design of TI-TMS system for deep brain stimulation with higher focus in neural modulationby Yanqing Zhang on 2 Luglio 2025
Transcranial magnetic stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate neurons in the brain and has been widely applied in the field of clinical neuromodulation. However, traditional TMS has limitations in terms of focality and stimulation depth, making it unable to achieve precise modulation of deep brain regions. As the stimulation depth increases, the focal area expands, potentially stimulating nontarget regions and causing negative side effects. Moreover,...
- Combined TMS and transcranial alternating current stimulation induced neuroplasticity in tremor-dominant Parkinson's diseaseby Jane Tan on 25 Giugno 2025
CONCLUSIONS: iTBS-γ-tACS(real), but not iTBS-γ-tACS(sham), elicited long-term potentiation-like neuroplastic changes in the target muscle.
- Early repetitive transcranial magnetic stimulation in the spinal cord region for the treatment of spinal cord injury: A case reportby Nannan Yang on 23 Giugno 2025
RATIONALE: Currently, the global incidence of spinal cord injury (SCI) ranges from approximately 10.4 to 83 cases per million individuals, with an estimated 500,000 new cases diagnosed annually. Current clinical treatments for SCI primarily include early surgical intervention, pharmacological therapy, and personalized rehabilitation programs. Transcranial magnetic stimulation (TMS) is a noninvasive, painless, and relatively safe treatment option that avoids the side effects and dependency...
- Investigating the Effects of Anodal Transcranial Pulsed Current Stimulation at Low Frequencies (0.5 to 5 Hz) on Corticospinal and Corticocortical Excitabilityby Mona Malekahmad on 17 Giugno 2025
The mechanism underlying transcranial pulsed current stimulation (tPCS) as a non-invasive neuromodulation technique has garnered considerable attention in recent years. However, the effects of anodal tPCS (a-tPCS) at low frequencies remain unexplored. This study aimed to investigate the a-tPCS effects at 0.5, 1, 3, and 5 Hz on cortical outcomes and its adverse side effects. This double-blinded, randomized, counterbalanced crossover trial included 18 healthy young participants who completed five...
