AGGIORNAMENTO SCIENTIFICO IN TEMPO REALE FORNITO DA:

  • Accidental catheter breakage during caudal epidural infiltration in an adult: An unusual complication
    by Paula Gil Esteller on 24 Aprile 2024

    Caudal epidural block is a simple and safe technique with a low complication rate commonly used for pediatric anesthesia and treatment of chronic lumbosacral pain. However, it is not exempt from some risks that, although infrequent, should be known. We describe the case of a 48-year-old female with chronic lumbosacral radicular pain who underwent caudal epidural infiltration. During the withdrawal of the catheter, accidental breakage and retention of a fragment at the level of the anterior...

  • Hippocampus diffusivity abnormalities in classical trigeminal neuralgia
    by Shaun Andrew Hanycz on 24 Aprile 2024

    CONCLUSION: This study demonstrates that TN is associated with microstructural hippocampal abnormalities, which may precede and potentially be temporally linked to volumetric hippocampal alterations demonstrated previously. These findings provide further evidence for the role of the hippocampus in chronic pain and suggest the potential for targeted interventions to mitigate cognitive symptoms in patients with chronic pain.

  • 12/15-Lipoxygenases mediate neuropathic-like pain hypersensitivity in female mice
    by B Brown on 22 Aprile 2024

    It is estimated that chronic neuropathic pain conditions exhibit up to 10% prevalence in the general population, with increased incidence in females. However, nonsteroidal inflammatory drugs (NSAIDs) are ineffective, and currently indicated prescription treatments such as opioids, anticonvulsants, and antidepressants provide only limited therapeutic benefit. In the current work, we extended previous studies in male rats utilizing a paradigm of central Toll-like receptor 4 (TLR4)-dependent,...

  • Selective modification of ascending spinal outputs in acute and neuropathic pain states
    by David A Yarmolinsky on 22 Aprile 2024

    Pain hypersensitivity arises from the plasticity of peripheral and spinal somatosensory neurons, which modifies nociceptive input to the brain and alters pain perception. We utilized chronic calcium imaging of spinal dorsal horn neurons to determine how the representation of somatosensory stimuli in the anterolateral tract, the principal pathway transmitting nociceptive signals to the brain, changes between distinct pain states. In healthy conditions, we identify stable, narrowly tuned outputs...

  • LncRNA-PCat19 acts as a ceRNA of miR-378a-3p to facilitate microglia activation and accelerate chronic neuropathic pain in rats by promoting KDM3A-mediated BDNF demethylation
    by Ziyu Zhao on 21 Aprile 2024

    The pathogenesis of neuropathic pain (NP) is complex, and there are various pathological processes. Previous studies have suggested that lncRNA PCAT19 is abnormally expressed in NP conduction and affects the occurrence and development of pain. The aim of this study is to analyze the role and mechanism of PCAT19 in NP induced by chronic compressive nerve injury (CCI) in mice. In this study, C57BL/6 mice were applied to establish the CCI model. sh-PCAT19 was intrathecally injected once a day for 5...

  • Quantitative Sensory Testing in Spinal Cord Stimulation: A Narrative Review
    by Turo Nurmikko on 19 Aprile 2024

    CONCLUSIONS: We recommend the adoption of QST into future clinical research protocols, using either the full QST protocol or a less time-demanding short-form QST.

  • Between-session chasing of losses and wins in an online eCasino
    by Ke Zhang on 24 Aprile 2024

    BACKGROUND AND AIMS: This study characterized chasing behaviour as the time to return to an online gambling website after a losing or a winning visit.

  • Nutritional Support for Moderate-to-Late-Preterm Infants - A Randomized Trial
    by Tanith Alexander on 24 Aprile 2024

    CONCLUSIONS: This trial of routine nutrition interventions to support moderate-to-late-preterm infants until full nutrition with mother's breast milk was possible did not show any effects on the time to full enteral feeding or on body composition at 4 months of corrected gestational age. (Funded by the Health Research Council of New Zealand and others; DIAMOND Australian New Zealand Clinical Trials Registry number, ACTRN12616001199404.).

  • The asymmetric impact of decision-making confidence on regret and relief
    by Zan Liu on 23 Aprile 2024

    When individuals make uncertain decisions, they often evaluate the correctness of their choices in what is referred to as decision-making confidence. The outcomes of such decision-making can lead to counterfactual thinking wherein alternative possible outcomes are contemplated. This, in turn, can elicit counterfactual emotions including upward and downward counterfactual thinking, which, respectively, refer to regret and relief. Decision-making confidence and counterfactual emotions have key...

  • Within-laboratory reproducibility of Ames test results: Are repeat tests necessary?
    by Errol Zeiger on 23 Aprile 2024

    The Ames test is required by regulatory agencies worldwide for assessing the mutagenic and carcinogenic potential of chemical compounds. This test uses several strains of bacteria to evaluate mutation induction: positive results in the assay are predictive of rodent carcinogenicity. As an initial step to understanding how well the assay may detect mutagens present as constituents of complex mixtures such as botanical extracts, a cross-sector working group examined the within-laboratory...

  • A Longitudinal Investigation of Lower-Risk Gambling Limits in the Canadian National Study
    by Nolan B Gooding on 23 Aprile 2024

    Recent years have seen increased attention given to identifying and describing the levels of gambling participation that confer a risk of harm in order to generate public health advice regarding lower-risk gambling. However, most of the existing literature has failed to explicitly assess these limits in a prospective manner. The purpose of this study is to employ a methodology consistent with prior investigations to evaluate the level of gambling participation associated with an increased risk...

  • Skill-Based Electronic Gaming Machines: Features that Mimic Video Gaming, Features that could Contribute to Harm, and Their Potential Attraction to Different Groups
    by Philip Newall on 23 Aprile 2024

    New gambling products have been developed over time as technology permits. For example, early mechanical slot machines were later replaced by electronic gaming machines (EGMs), which enabled a faster speed of play and more immersive experience. EGMs have in the decades since their invention become one of the main drivers of gambling expenditure worldwide and are one of the gambling products most strongly associated with harm. This literature review considers research relevant to a new...

  • Outcomes of Anorexia Nervosa in a Male Patient Treated With Paroxetine: A Case Report
    by Mohammed Alkhamis on 24 Aprile 2024

    Eating disorders (EDs) are among the most dangerous mental illnesses, that are characterized by high mortality rates, multisystem comorbidity, and an often chronic and relapsing disease course. EDs occur most commonly in the female gender, with a ratio of 10 females to 1 male for anorexia nervosa (AN). We present the case of a 15-year-old Saudi boy who presented with weight loss (BMI 11.6 kg/m²) and began to have symptoms of obsessive-compulsive disorder (OCD) in prayer and ablution. His first...

  • Practical guidelines for eating disorder risk mitigation in patients undergoing obesity treatment for the pediatric provider
    by Katelyn Gordon on 24 Aprile 2024

    PURPOSE OF REVIEW: Pediatric obesity is a growing concern globally. Patients with a history of overweight/obesity often experience stigmatization, especially in the healthcare setting, and are at increased risk of developing psychological comorbidities including eating disorders. This review appraises the most recent studies evaluating eating disorder risk in youth undergoing treatment for obesity, identifies gaps in the literature, and offers practical guidelines to pediatric providers...

  • PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association
    by Marcel Proske on 24 Aprile 2024

    Mutations in the human PURA gene cause the neurodevelopmental PURA syndrome. In contrast to several other monogenetic disorders, almost all reported mutations in this nucleic acid-binding protein result in the full disease penetrance. In this study, we observed that patient mutations across PURA impair its previously reported co-localization with processing bodies. These mutations either destroyed the folding integrity, RNA binding, or dimerization of PURA. We also solved the crystal structures...

  • Effect of obesity on mood regulation and eating attitudes in mental disorders
    by Hayriye Baykan on 24 Aprile 2024

    CONCLUSION: While a partial and meaningful correlation was observed among body mass index, eating attitudes, and emotion regulation difficulties, it is suggested that factors such as patients' age, disease duration, current body mass index, and the simultaneous presence of depression and anxiety should be considered.

  • Thinning of the retinal nerve fiber and choroidal layers in adolescents with anorexia nervosa: A controlled study
    by Ceyda Baskan on 24 Aprile 2024

    CONCLUSION: The retinal nerve fiber layer and choroidal layer thicknesses were lesser in patients with anorexia than in healthy controls. Screening for retinal indices might prevent the development of irreversible retinal pathologies in adolescents with anorexia nervosa. In addition, thinning of the retinal nerve fiber and choroidal layers could reflect structural or functional changes in the brain of adolescents with anorexia nervosa.

  • Adolescents Who Do Not Endorse Risk via the Patient Health Questionnaire Before Self-Harm or Suicide
    by Jean P Flores on 24 Aprile 2024

    CONCLUSIONS AND RELEVANCE: Study results suggest that older age, history of an inpatient mental health encounter, or being screened in primary care were associated with at-risk adolescents being less likely to endorse having thoughts of death and self-harm on the PHQ item 9 before a self-harm event or suicide death. As use of the PHQ becomes more widespread in practice, additional research is needed for understanding reasons why many at-risk adolescents do not endorse thoughts of death and...

  • Outcomes of Anorexia Nervosa in a Male Patient Treated With Paroxetine: A Case Report
    by Mohammed Alkhamis on 24 Aprile 2024

    Eating disorders (EDs) are among the most dangerous mental illnesses, that are characterized by high mortality rates, multisystem comorbidity, and an often chronic and relapsing disease course. EDs occur most commonly in the female gender, with a ratio of 10 females to 1 male for anorexia nervosa (AN). We present the case of a 15-year-old Saudi boy who presented with weight loss (BMI 11.6 kg/m²) and began to have symptoms of obsessive-compulsive disorder (OCD) in prayer and ablution. His first...

  • Genomics of severe and treatment-resistant obsessive-compulsive disorder treated with deep brain stimulation: A preliminary investigation
    by Long Long Chen on 23 Aprile 2024

    Individuals with severe and treatment-resistant obsessive-compulsive disorder (trOCD) represent a small but severely disabled group of patients. Since trOCD cases eligible for deep brain stimulation (DBS) probably comprise the most severe end of the OCD spectrum, we hypothesize that they may be more likely to have a strong genetic contribution to their disorder. Therefore, while the worldwide population of DBS-treated cases may be small (~300), screening these individuals with modern genomic...

  • Intensive exposure treatment for obsessive compulsive disorder in old age.
    by M G Guineau on 23 Aprile 2024

    The absence of treatment studies for obsessive compulsive disorder (OCD) in older adults and the fact that OCD typically starts at a young age and often follows a chronic, fluctuating course quickly leads to therapeutic nihilism for older adults with OCD. In this case report, we present a 72-year-old man with OCD symptoms from the age of 35, who has only been treated with medication and psychotherapy for a recurrent depressive disorder. After a short, intensive exposure and response prevention...

  • Repetitive Behaviors in Autism and Obsessive-Compulsive Disorder: A Systematic Review
    by Jessica O'Loghlen on 23 Aprile 2024

    CONCLUSION: Further research into differences in the presentation of repetitive behaviors at a subscale and item level is required to inform clearer differentiation of specific behaviors in autism versus OCD. Understanding and more accurately differentiating is essential for efficient diagnosis, effective treatment, and better outcomes.

  • The anxiety response of patients with severe psychiatric disorders to the recent public health crisis
    by Mohammadrasoul Khalkhali on 23 Aprile 2024

    CONCLUSION: Anxiety response to health crisis is different in groups with SPDs and control group. The findings of this study suggest that although health anxiety is present in many of these patients during the pandemic, their anxiety response to the health crisis may be less than expected. There can be various explanations, such as pre-existing symptoms, low health literacy, and possible co-occurring cognitive impairment. The results of this study have many practical and policy implications in...

  • Advances in the Treatment of Osteochondral Lesions of the Talus
    by Yongsheng Li on 22 Aprile 2024

    Osteochondral lesion of the talus (OLT) is a localized cartilage and subchondral bone injury of the talus trochlea. OLT is caused by trauma and other reasons, including osteochondritis dissecans of the talus (OCD) and talus osteochondral tangential fracture. OLT can develop from being asymptomatic to subchondral bone cysts accompanied by deep ankle pain. OLT tends to occur on the medial and lateral sides of the talar vault. OLT seriously affects the patients' life and work and may even lead to...

  • Outcomes of Anorexia Nervosa in a Male Patient Treated With Paroxetine: A Case Report
    by Mohammed Alkhamis on 24 Aprile 2024

    Eating disorders (EDs) are among the most dangerous mental illnesses, that are characterized by high mortality rates, multisystem comorbidity, and an often chronic and relapsing disease course. EDs occur most commonly in the female gender, with a ratio of 10 females to 1 male for anorexia nervosa (AN). We present the case of a 15-year-old Saudi boy who presented with weight loss (BMI 11.6 kg/m²) and began to have symptoms of obsessive-compulsive disorder (OCD) in prayer and ablution. His first...

  • Practical guidelines for eating disorder risk mitigation in patients undergoing obesity treatment for the pediatric provider
    by Katelyn Gordon on 24 Aprile 2024

    PURPOSE OF REVIEW: Pediatric obesity is a growing concern globally. Patients with a history of overweight/obesity often experience stigmatization, especially in the healthcare setting, and are at increased risk of developing psychological comorbidities including eating disorders. This review appraises the most recent studies evaluating eating disorder risk in youth undergoing treatment for obesity, identifies gaps in the literature, and offers practical guidelines to pediatric providers...

  • PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association
    by Marcel Proske on 24 Aprile 2024

    Mutations in the human PURA gene cause the neurodevelopmental PURA syndrome. In contrast to several other monogenetic disorders, almost all reported mutations in this nucleic acid-binding protein result in the full disease penetrance. In this study, we observed that patient mutations across PURA impair its previously reported co-localization with processing bodies. These mutations either destroyed the folding integrity, RNA binding, or dimerization of PURA. We also solved the crystal structures...

  • Effect of obesity on mood regulation and eating attitudes in mental disorders
    by Hayriye Baykan on 24 Aprile 2024

    CONCLUSION: While a partial and meaningful correlation was observed among body mass index, eating attitudes, and emotion regulation difficulties, it is suggested that factors such as patients' age, disease duration, current body mass index, and the simultaneous presence of depression and anxiety should be considered.

  • Thinning of the retinal nerve fiber and choroidal layers in adolescents with anorexia nervosa: A controlled study
    by Ceyda Baskan on 24 Aprile 2024

    CONCLUSION: The retinal nerve fiber layer and choroidal layer thicknesses were lesser in patients with anorexia than in healthy controls. Screening for retinal indices might prevent the development of irreversible retinal pathologies in adolescents with anorexia nervosa. In addition, thinning of the retinal nerve fiber and choroidal layers could reflect structural or functional changes in the brain of adolescents with anorexia nervosa.

  • Adolescents Who Do Not Endorse Risk via the Patient Health Questionnaire Before Self-Harm or Suicide
    by Jean P Flores on 24 Aprile 2024

    CONCLUSIONS AND RELEVANCE: Study results suggest that older age, history of an inpatient mental health encounter, or being screened in primary care were associated with at-risk adolescents being less likely to endorse having thoughts of death and self-harm on the PHQ item 9 before a self-harm event or suicide death. As use of the PHQ becomes more widespread in practice, additional research is needed for understanding reasons why many at-risk adolescents do not endorse thoughts of death and...