AGGIORNAMENTO SCIENTIFICO IN TEMPO REALE FORNITO DA:
- Sources of the N15 TMS-evoked potential following motor cortex stimulation localize rostrals to TMS-induced electric fields and depend on doseby Sybren Van Hoornweder on 12 Settembre 2026
Transcranial magnetic stimulation (TMS) elicits characteristic cortical responses known as TMS-evoked potentials (TEPs) measured via electroencephalography (EEG). An early negative peak can be consistently evoked over the motor cortex at around 15 ms (N15). It remains elusive whether N15 overlaps with the cortical regions receiving the highest TMS-induced electric field (E-field). We characterized the source activity of the N15 component relative to the TMS-induced E-field in 16 healthy adults...
- Causal evidence for dorsal stream involvement in object shape recognition: A tractography-guided ccPAS Registered Report studyby Elena Bertacco on 10 Settembre 2026
Visual experience requires orchestration of intricate brain connections. One of the most influential models of human visual information processing posits two segregated streams and postulates that conscious object recognition relies exclusively on the ventral visual stream. However, recent evidence suggests that the dorsal stream is involved in encoding crucial attributes of visual object recognition, such as global shape. The specific role of the dorsal stream is controversial in this context....
- Non-invasive brain stimulation in amyotrophic lateral sclerosis: a systematic review and meta-analysis of transcranial direct current stimulation and transcranial magnetic stimulationby Bassel Alrabadi on 10 Settembre 2026
CONCLUSION: Noninvasive brain stimulation in ALS does not significantly improve functional outcomes, but induces measurable neurophysiological changes with a strong safety profile. Further studies should optimize protocols and identify responsive subgroups.
- Vanderbilt Integrated Community TMS for Opioid Recovery (VICTORY): Study protocol for a randomized, controlled trial of non-invasive brain stimulation to reduce craving in people with opioid use disorderby Kathryn Biernacki on 10 Settembre 2026
BACKGROUND: Individuals receiving buprenorphine treatment for opioid use disorder (OUD) remain at high risk for treatment discontinuation and return to opioid use. Transcranial magnetic stimulation (TMS) has shown efficacy in reducing craving and substance use in other substance use disorders, but its application in OUD remains limited and the neural mechanism underlying its therapeutic effects is poorly understood. Determining the feasibility and generalizability of TMS in patients receiving...
- Advanced imaging-integrated rTMS therapy for frontal network recovery after traumatic brain injuryby Nan Hu on 9 Settembre 2026
CONCLUSION: High-frequency left-DLPFC rTMS exposure was associated with improved executive recovery and measurable frontal-network modulation after traumatic brain injury. These findings suggest that multimodal neurophysiological and imaging biomarkers may provide useful measures of target engagement for future prospective studies. Given the retrospective observational design, modest sample size, and short-term follow-up, causal inferences regarding treatment effects or biomarker-guided...
- Mapping and modulating brain dynamics in aging and neurodegeneration with electroencephalography and integrated neurotechnologies in primatesby Ankur Gupta on 9 Settembre 2026
Non-human primates (NHPs) provide an essential translational platform for investigating neural mechanisms underlying brain aging and neurodegenerative diseases. Their neuroanatomical organization, cortical complexity, and cognitive capacities share close parallels with those of humans, enabling a degree of experimental precision that rodent models cannot achieve. Electroencephalography (EEG) offers a non-invasive method for monitoring neuronal population activity with high temporal resolution,...
- Integrative Rehabilitation for War-Related Polytrauma: A Narrative Review of Multidimensional Strategies and Implementation Challengesby Ji Sun on 15 Settembre 2026
CONCLUSIONS: Addressing the war-related rehabilitation gap requires integration of biomedical care, technology-assisted rehabilitation, and evidence-graded non-pharmacological adjuncts within a structured biopsychosocial framework. Future priorities include pragmatic, adapted trial designs (e.g., stepped-wedge or cohort-embedded designs, which are more feasible than classical RCTs under wartime conditions) for acupuncture in phantom limb pain, feasibility trials for robotic rehabilitation in...
- Chronic postsurgical pain after living donor hepatectomy: Pay attention to donor featuresby Tufan Gumus on 15 Settembre 2026
Postoperative pain lasting longer than 90 days is defined as chronic postsurgical pain (CPSP) and is known to be a long-term bothersome problem for surgical patients. The study presents the incidence, characteristics, and risk factors of CPSP in living donor hepatectomy (LDH). This was a single-center, retrospective study using the institution's electronic files and the CPSP questionnaire completed during the telephone interview. Of 123 patients assessed, 114 (92.6%) had acute postoperative...
- Aetiology of pelvic neuropathies in women: a narrative reviewby Robert de Leeuw on 15 Settembre 2026
Pelvic neuropathy is an under-recognised contributor to chronic pelvic pain in women, yet a structured overview of its identifiable causes has been lacking. In this narrative review we searched PubMed, Embase and Web of Science from inception to 1 March 2024 for clinical studies describing pelvic neuropathy in women with a defined or inferable aetiology, and synthesised them thematically. We included 306 studies (215 case reports, 53 case series, 24 retrospective and 14 prospective cohort...
- Health-Related Quality of Life and Mid-Term Oncological Outcomes After Subcostal Uniportal Robot-Assisted Lung Cancer Surgery: A Secondary Analysis of a Clinical Trialby Chuan Cheng on 15 Settembre 2026
CONCLUSIONS: Subcostal URATS was feasible in this prospective cohort. Chronic postsurgical pain was mild and decreased over time, HRQOL remained well preserved, although data on mid-term oncological outcomes were preliminary.
- State of the Art in Neuromodulation or Spinal Cord Stimulation Therapyby Nafay Abdul on 15 Settembre 2026
Chronic pain continues to be a major global health burden and is frequently refractory to conventional pharmacologic and conservative therapies. Spinal cord stimulation (SCS) has emerged as an important neuromodulatory treatment for selected patients with chronic neuropathic and mixed pain syndromes. Since its introduction in the 1960s, SCS has evolved from paresthesia-based tonic stimulation into more adaptive and personalized neuromodulation. This review summarizes the current evidence...
- Neural Mechanisms and Brain Alterations in Orofacial Pain: A Narrative Review of Human Neuroimagingby Nelson Freitas on 15 Settembre 2026
Orofacial pain is a complex and multifactorial condition that affects quality of life and presents important diagnostic and therapeutic challenges. Advances in neuroimaging techniques have enabled the investigation of nervous system alterations associated with pain perception and modulation. This review synthesizes current evidence on structural, functional, and neurochemical brain alterations identified through magnetic resonance imaging (MRI) in individuals with acute and chronic orofacial...
- Seriously Considering Humor as a Therapeutic Support for Addiction Recoveryby Samuel W Stull on 15 Settembre 2026
Humor interventions can increase happiness and reduce mental health symptoms such as depression and anxiety. Several authors have direct lived experience of these benefits, with humor being transformative early and throughout their addiction recovery. Yet the scientific study of humor as a support for recovery remains largely unexamined. We argue this is a missed opportunity and offer a rationale for advancing this area of research. We propose that humor aligns with putative therapeutic...
- A Prayer Before Induction: A Philosophical Analysis of Spiritual Coping, Vulnerability, and Trust in Holistic Nursing Careby Ariyachart Kalawa on 15 Settembre 2026
Prayer before anesthesia induction is a philosophically significant act that may reveal how vulnerability, agency, dignity, and trust are experienced at the threshold of unconsciousness. This philosophical analysis examines patient-initiated prayer from a holistic nursing perspective, bringing spiritual coping theory, accounts of vulnerability and fiduciary trust, conceptions of dignity and personhood, and cultural humility into dialog. Prayer may represent fear, meaning-making, gratitude,...
- Climate anxiety: defining and responding to an emerging mental health challengeby Susan Clayton on 15 Settembre 2026
No abstract
- Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and preventionby Claudia Aymerich on 15 Settembre 2026
Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Following a pre-registered protocol, we searched the Web of Science for systematic reviews with meta-analyses of observational studies published between the search date of the last umbrella review (February 1, 2017) and...
- Resetting the hippocampal buffer: a neurocognitive account of psychedelic therapy for anxiety-related psychopathologyby Hugh McGovern on 15 Settembre 2026
Psychedelics (hallucinogenic 5-HT(2A) agonists such as psilocybin) are being investigated for their potential to treat a range of conditions, including anxiety-related psychopathology. Despite promising results, the mechanisms by which psychedelic therapy may alleviate anxiety are not well understood. Here, we review neural and cognitive mechanisms underlying anxiety-related psychopathology and how psychedelics may impact these mechanisms. This review culminates in a tentative neurocognitive...
- Mental health disparities in LGBTQIA+ populations: an umbrella review of systematic reviews and meta-analysesby Vincenzo Oliva on 15 Settembre 2026
Lesbian, gay, bisexual, transgender, questioning, intersex, asexual (LGBTQIA+) populations face unique social, political, psychological and health care-related challenges that contribute to marked mental health disparities. However, the overall strength and credibility of evidence across mental disorders, mental disorder-related symptomatology, suicidal or self-harm behaviors, and access to mental health care have not been systematically assessed in these populations. We conducted an umbrella...
- Factors Influencing the Clearance of Polystyrene Microplastics by Oysters: Roles of Environmental Conditions, Food Availability and Selectionby Yanping Li on 15 Settembre 2026
This study investigated the abiotic and biotic factors regulating the removal of polystyrene microplastics (PS-MPs) from the water column by the oyster Crassostrea hongkongensis. Our data revealed that MP sequestration is highly dependent on environmental conditions and food characteristics. Optimal clearance occurred at 25 °C and medium estuarine salinity (20 psu), while extreme thermal stress (30 °C) and hyposaline conditions (5 psu) significantly depressed filtration. Light condition had...
- Differential trajectories of depression symptoms during pregnancy and prospective associations with postpartum eating disorder symptoms and cardiovascular health behaviorsby Caroline Christian on 15 Settembre 2026
CONCLUSIONS: Prenatal depressive symptom trajectories may differentially relate to risk for postpartum ED symptoms and sleep behaviors among higher weight pregnant people. Future research should continue investigating perinatal depression, ED symptoms, and associated health behaviors to optimize screening and intervention in maternal healthcare.
- The effects of episodic simulation on the cognitive and emotional expectancies related to personal goalsby Rachel J Anderson on 15 Settembre 2026
Episodic simulation influences future expectancies such as likelihood, controllability, and anticipated emotions of future events. We extended the use of episodic simulation to expectancies associated with personal goals. Participants listed personal goals and provided ratings of cognitive and emotional expectancies. They then completed one of four tasks (goal-related episodic simulation, goal-unrelated episodic simulation, neutral imagery, or letter-search) before providing two further sets of...
- Effectiveness of symptom map-based education in the management of premenstrual syndrome: a randomized controlled trialby Ahsen Demirhan Kayacik on 15 Settembre 2026
CONCLUSION: A symptom map-based educational intervention is a clinically applicable, non-pharmacological approach for PMS management. This structured education appears especially beneficial for women with more severe baseline symptoms and may be integrated into routine gynecological care to support individualized symptom management.
- Lithium-associated peripheral transcriptional signatures correlate with brain white matter microstructure in bipolar disorderby Diana Betelli on 15 Settembre 2026
Lithium is the mainstay treatment for bipolar disorder, improving brain white matter microstructure and regulating genes involved in immune response and cell signaling. In 116 patients affected by a major depressive episode in the course of bipolar disorder, we investigated the effect of long-term lithium treatment on gene expression in peripheral blood mononuclear cells and their association with white matter microstructure. Differential gene expression analysis identified three genes...
- Sexual dysfunction in peritoneal dialysis: associated factors and exploratory machine-learning classificationby Li Deng on 15 Settembre 2026
CONCLUSIONS: Sexual dysfunction was common among respondents receiving peritoneal dialysis. In men, higher depression scores and lower 24-h urine volume were associated with male erectile function scores, whereas in women associations were weaker and primarily socioeconomic. The models and SHAP-derived feature rankings should therefore be considered exploratory and require prospective external validation before clinical use.
- Trends in Prevalence of Opioid Dependence in Scotland 2014-2023: Multi-Parameter Estimation of Prevalenceby Andreas Markoulidakis on 15 Settembre 2026
INTRODUCTION: Scotland remains in the midst of a public health crisis driven by drug-related deaths, with rates reaching 2.0 per 100 person-years in 2020-22. Estimates of the prevalence of opioid dependence are critical for supporting policy decisions and better understanding the factors behind this rise.
- Substance-related visual cues alter sensory gating in adults who regularly use methamphetamineby Peihan J Huang on 15 Settembre 2026
CONCLUSIONS: Adults who use methamphetamine exhibit altered gating responses and elevated spontaneous gamma activity in the somatosensory cortices, likely reflecting disruptions in GABAergic circuitry. Substance-related cues accentuated gating deficits, suggesting that cue reactivity may compromise sensory inhibition in this population.
- Transcriptome Analysis of Hippocampus After Weekly Binge Alcohol Exposure and Voluntary Exercise in Ratsby Erika A Mehrhoff on 15 Settembre 2026
CONCLUSIONS: Our results suggest that five weekly treatments of binge alcohol minimally alter the hippocampal transcriptome assessed 20 h after the last binge. However, binge ethanol exposure markedly blunted exercise effects on the transcriptome, suggesting future study of this interaction is merited. Deconvolution showed similar patterns, upholding its utility as a supplemental analysis for bulk sequencing studies.
- Competitive Bias in Severe Alcohol Use Disorder: An Exploration Through the Prisoner's Dilemma Paradigmby Mado Gautier on 15 Settembre 2026
CONCLUSIONS: SAUD is characterized by a competitive bias during social decision-making. Such bias, despite leading to more advantageous decisions at the economic level, suggests difficulties in understanding others' intentions and behaving accordingly in social situations, which could favor social difficulties and relapse.
- Reward Prediction Errors Drive Reinforcement Learning and Recognition Memory: Gender Differences in Methamphetamine Abusersby YuQing Liu on 15 Settembre 2026
CONCLUSION: These findings suggest that methamphetamine abuse impairs RPE-dependent learning and memory, with reduced RPE utilization efficiency specifically observed in female abusers-manifested as larger prediction errors but lower learning rates.
- Differential Cancer Risks and Noninvasive Predictors in MASLD, MetALD, and ALD: A Longitudinal Analysisby Hana Park on 15 Settembre 2026
CONCLUSIONS: Cancer risk differs across MASLD, MetALD, and ALD, with alcohol-related phenotypes carrying the highest burden. Noninvasive fibrosis indices such as FIB-4 and SAFE may help stratify risk-though largely age-related-and could inform risk-based surveillance in SLD.
- A Comprehensive Review on the Biosynthesis of Tropane Alkaloidsby Shiyu Wan on 15 Settembre 2026
Tropane alkaloids (TA) constitute a class of plant specialized metabolites with important pharmaceutical applications, including the anticholinergic agents hyoscyamine and scopolamine and the local anesthetic cocaine. Over the past decade, advances in genomics, structural biology, and synthetic biology have substantially revised our understanding of TA biosynthesis, leading to the identification of numerous key biosynthetic enzymes and evolutionary mechanisms. This review comprehensively...
- Erratum for: Legal responses to new psychoactive substances in Europe: countries inside the REITOX network, Norway, and Türkiyeby Valeria Aquilina on 15 Settembre 2026
Ann Ist Super Sanità 2026 | Vol. 62, No. 2: 100-114 DOI: 10.4415/ANN_26_02_02 In the originally published version of this manuscript, an error occurred in the third column of Table 1 (Italy drug scheduling section, page 105) reporting the drug scheduling for Italy. The correct drug scheduling should read: "The scheduling system classifies substances into five Tables: - Table I: substances with highest abuse potential (e.g., heroin, cocaine, amphetamines) - Table II: cannabis products (e.g....
- Examining the Fourth Wave of the Opioid Epidemic: What Nurses Need to Know?by Deborah A Salani on 14 Settembre 2026
The United States continues to experience an opioid epidemic, which has been described by three waves: prescription opioid use, heroin use, and use of synthetic fentanyl analogs. Currently, a new "fourth wave" has emerged, which includes the use of stimulants (methamphetamine and cocaine) and synthetic opioids. Combining stimulants with high-potency synthetic opioids, such as fentanyl and fentanyl analogs, is associated with an increased mortality. Recent changes in methamphetamine production...
- Necrosis or Related Skin Changes After Subcutaneous Injection of Buprenorphine Extended-Release: A Case Seriesby Stanley Wong on 14 Settembre 2026
OBJECTIVES: To describe eight cases of necrosis and related skin changes following a once-monthly subcutaneous buprenorphine extended-release (Bup-XR) injection, identify potential risk factors, and increase clinician awareness of this adverse drug reaction.
- Systemic Everolimus Does Not Block the Incubation of Methamphetamine-Craving: A Dose-Response Studyby Fernando J Cano on 13 Settembre 2026
In rodent models, incubated craving for drugs and natural reinforcers is characterized by a time-dependent increase in cue-elicited operant responding, which posits that common biochemical mechanisms gate incubated craving across different types of reinforcers. Recently, our laboratory identified heightened mTOR activity in the prelimbic (PL) and infralimbic (IL) subregions of the medial prefrontal cortex (mPFC) as being associated with incubated craving for cocaine and sucrose, respectively....
- Cocaine, cannabis, champagne-pharmacological and toxicological references in the lyrics of the German rapper Haftbefehl: a content analysisby Carina Spark on 13 Settembre 2026
In popular music, references to (illicit) drugs are widespread and may influence attitudes and behaviors in relation to substance use and abuse, especially among younger generations. While substance-related content in international pop and rap music has been studied extensively, the German rap scene has received comparatively little attention thus far. This study aimed to systematically analyze the lyrics of one of the most well-known German rappers, Haftbefehl (literal translation: "arrest...
- Nutritional Safety and Health Resilience in Europe: Declining Micronutrient Intakes, Widening Distributional Disparities and Persistent Inadequacies Revealed from National Dietary Surveysby Samantha Christie on 15 Settembre 2026
Background: Nutritional safety has traditionally focused on preventing excessive nutrient exposure, yet chronic micronutrient inadequacy may also impair physiological function and health resilience. As the European Commission prepares to harmonise maximum permitted levels for food supplements and fortified foods, understanding long-term population intake trends is increasingly important. We assessed changes in micronutrient intakes and adequacy among adults in four European countries. Methods:...
- Mediterranean Diet Adherence and Screening Indicators of Gambling-Related Problems in a Sample of Young Adults: An Exploratory Cross-Sectional Analysis of the EVA-Adic Studyby Cristina Saldaña-Ruiz on 15 Settembre 2026
Background/Objectives: Gambling disorder is recognized as a behavioral addiction, and gambling-related problems represent an important public health concern among young adults. However, evidence regarding their association with overall diet quality, particularly adherence to the Mediterranean diet (MedDiet), remains scarce. This exploratory secondary analysis examined whether screening indicators of gambling-related problems were associated with MedDiet adherence in young adults. Methods: We...
- Real-world effectiveness of fluticasone propionate-azelastine nasal spray in moderate-to-severe nonallergic and perennial allergic rhinitisby Piyaporn Chokevittaya on 15 Settembre 2026
CONCLUSION: The effectiveness of FP-Aze in moderate-to-severe NAR was noninferior to PAR on the VAS for rhinitis, supporting its use in this population. These findings help address an important evidence gap, as data supporting FP-Aze in NAR remain limited.
- A Gambling Financial Harm Screener (GFHS) for Payment Institutions: Multi-Method Development and Preliminary Validationby Nathan Lakew on 15 Settembre 2026
Disordered gambling, a form of behavioral addiction characterized by persistent gambling despite harmful consequences, is inherently associated with financial harm. While established diagnostic instruments exist, they are primarily designed for clinical or gambling-service contexts and are not readily applicable within financial system infrastructures that process gambling-related transactions. The current study describes the development and initial validation of the Gambling Financial Harm...
- Addictions are linked but distinct: A transdiagnostic network analysis of concurrent disorder riskby Spencer Murch on 15 Settembre 2026
BACKGROUND AND AIMS: Concurrent disorder refers to the co-occurrence of one or more addictive disorder(s) alongside one or more other mental health disorder(s). To identify psychotherapy targets most-closely related to concurrent disorders, we modeled addiction and mental health symptom severities alongside relevant cognitive psychological factors using pairwise Markov random fields.
- Use of artificial intelligence within the gambling field: a scoping review protocolby Ståle Pallesen on 14 Settembre 2026
INTRODUCTION: This scoping review aims to map existing studies that have employed artificial intelligence (AI) tools within the gambling field, examining their areas of use, current trends, and key findings.
- Food Allergies and Eating Disorders: An Exploration of Screening Prevalence and Associated Factors Among Adultsby Jessica Hine on 15 Settembre 2026
Background/Objectives: Food allergy (FA) affects up to 10% of adults and requires ongoing dietary vigilance that may increase vulnerability to eating disorders (EDs), yet evidence in adults remains limited. This study compared ED screening and history between adults with and without food allergy (FA), and explored factors associated with positive screening among those with FA. Methods: This cross-sectional study recruited 371 adults (134 with FA, 237 without) via an online survey. Positive...
- Behavioral Profiles of Exam Stress: Mapping Student Diet, Sleep, and Substance Useby Andreea-Sabina Butucaru on 15 Settembre 2026
Background: Academic pressure during examination periods is frequently reported alongside irregular lifestyle behaviors. The study aimed to explore the interplay between habitual eating behaviors, sleep quality, and self-reported stimulant use and coping adaptations specifically during examination periods among healthcare university students. Methods: This cross-sectional study included 265 university students (Mage = 22.00, SD = 4.46). Dietary behaviors and sleep quality were assessed using the...
- High- and Low-Calorie Food Cues, Visual Attention, and Subclinical Eating Pathology in University Students Assessed by Eye Trackingby Csongor István Szepesi on 15 Settembre 2026
Background/Objectives: Eating disorders are increasingly conceptualized as information-processing disorders characterized by attentional biases toward food-related stimuli. However, whether such biases are already detectable in subclinical, non-treatment-seeking populations remains unclear. This study examined whether subclinical eating pathology, assessed with the Eating Attitudes Test-26 (EAT-26), is associated with distinct patterns of visual attention toward high- and low-calorie food images...
- Integrative Nutritional Strategies for Performance, Recovery, and Weight Management in Taekwondoby Adam Tawfiq Amawi on 15 Settembre 2026
Taekwondo is a high-intensity, intermittent, weight-category combat sport requiring repeated explosive actions, rapid decision-making, and effective recovery between bouts. These demands, combined with congested competition schedules and weight-management requirements, make nutrition important for both performance and athlete health. This narrative review provides an evidence-informed synthesis of nutritional strategies relevant to taekwondo performance, recovery, and weight management by...
- Associations of Diabetes-Related Distress, Disordered-Eating Risk, and Self-Perceived Health with Glycemic Outcomes in Adolescents with Type 1 Diabetes: An Exploratory Cross-Sectional Studyby Marta García-Poblet on 15 Settembre 2026
Background/Objectives: Adolescents with type 1 diabetes mellitus (T1DM) are particularly vulnerable to psychological distress, disordered-eating (DE) risk and negative self-perceived health status (SPHS), which may compromise metabolic control and self-care. Although these factors have been studied individually, the usefulness of brief and clinically feasible screening tools to detect these dimensions remains underexplored. This study aimed to: (1) examine associations between distress, DE risk...
- Prevalence and Clinical Correlates of Autistic Traits Across Eating Disorder Diagnoses: A Retrospective Analysis of Clinical Service Databy Adia Meyer on 15 Settembre 2026
Background: Autistic traits are overrepresented among individuals with anorexia nervosa (AN) and are associated with greater eating disorder (ED) psychopathology, psychological distress, and work and social functioning difficulties in this population. However, less is known about the prevalence and clinical associations of autistic traits in other ED presentations, such as bulimia nervosa (BN). This study examined the prevalence of autistic traits and their associations with ED psychopathology,...
- Deep brain stimulation for Tourette syndrome: a systematic review and meta-analysisby Shenshen Li on 15 Settembre 2026
Deep brain stimulation (DBS) has emerged as a promising neuromodulatory therapy for patients with refractory Tourette syndrome (TS). Various brain targets-including the globus pallidus internus (GPi) and several thalamic nuclei-have been explored, yet the comparative efficacy of DBS in different targets remain unclear. This meta-analysis aims to evaluate the clinical efficacy of DBS in TS and assess symptom improvements across different stimulation targets. A systematic search of PubMed, Embase,...
- Early motor trajectories and distinct psychopathological profiles in adolescents born very and extremely pretermby Emanuela Claudia Turco on 15 Settembre 2026
CONCLUSIONS: Very and extremely preterm birth are associated with long-term neurodevelopmental and psychopathological vulnerability. Early motor development appears to be a key predictor of later social functioning, potentially shaping distinct developmental trajectories toward autism-related features or psychosis vulnerability.
- Network analysis of the genetic relationships between twenty psychiatric and substance use disordersby Kenneth S Kendler on 15 Settembre 2026
We sought to clarify, using network analysis, the structure of genetic risk factors for a wide range of psychiatric and substance use disorders. Using split halves (N=1,510,974), we computed the family genetic risk scores (FGRSs) for 20 psychiatric and substance use disorders assessed in treated individuals from the entire Swedish population born between 1960 and 2000. We calculated a genetic correlation matrix for them to which we applied an EBICglasso network analysis. The network was dense,...
- Are we missing obsessive-compulsive disorder in children with severe intellectual disability?by Annie Swanepoel on 14 Settembre 2026
Obsessive-compulsive disorder (OCD) is being missed in children with severe intellectual disability. Their compulsive behaviours are routinely attributed to autism spectrum disorder or dismissed as challenging behaviour, without systematic consideration of OCD. I argue that this misattribution is predictable, consequential and correctable. The key diagnostic tool is the ego-dystonic/ego-syntonic distinction: OCD rituals are distressing to the child and a change from their baseline, whereas...
- Psychodynamic Psychotherapy for Obsessive-Compulsive Disorder: A Single-Case Report with Quantified Outcomesby Paolo Mandolillo on 14 Settembre 2026
Obsessive-compulsive disorder (OCD) remains a disabling condition for a subset of patients who fail to respond to first-line behavioral protocols. We report a measurement-informed psychodynamic psychotherapy case of an adult with DSM-5 OCD characterized by harm- and contamination-related intrusions with checking/washing rituals. The patient received psychodynamic treatment using clarification, confrontation, and interpretation, focused on defenses of isolation of affect, undoing, and...
- Understanding the co-occurrence of OCD and PTSD: A network approachby Samantha N Hellberg on 14 Settembre 2026
Obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD) often co-occur, complicating the presentation, severity, and treatment of these conditions. Relationships among the symptoms of these disorders may contribute to their co-occurrence. This study aimed to extend recent work on comorbid OCD+PTSD and to examine its network structure in a clinical sample of 137 treatment-seeking patients at two large healthcare institutions. Confirmatory factor analysis was used to examine...
- 5-HT2A receptor activation is dispensable for psilocybin-induced fear extinction and neuroplasticity in miceby Yingjie Du on 15 Settembre 2026
CONCLUSIONS: The effects of psilocybin in facilitating fear extinction and increasing neuroplasticity in fear-conditioned mice are not dependent on 5-HT2A receptor activation, which supports that its therapeutic and hallucinogenic effects can be dissociated.
- Clinical and subthreshold insomnia in U.S. veterans: increasing prevalence and mental health burdenby Robert H Pietrzak on 15 Settembre 2026
This study examined the prevalence, correlates, and mental health burden of insomnia in a contemporary, nationally representative sample of 2,632 U.S. military veterans. Using established cutoffs on the Insomnia Severity Index (clinical insomnia, ≥ 15; subthreshold insomnia, 8-14), 13.6% of veterans met criteria for clinical insomnia and 29.7% for subthreshold insomnia, representing significant increases from the 11.4% and 26.0% observed in a nationally representative veteran sample surveyed in...
- Role of the Amygdala in the Complex Relationship Between Sleep and Anxietyby Filip Grzybowski on 15 Settembre 2026
This review explores the multifaceted roles of the amygdala, focusing on its structural components, projections, physiological aspects, and key functions in emotional processing and fear conditioning. Beyond traditional roles, it examines the amygdala's involvement in sleep architecture during the NREM and REM phases. In NREM sleep, the amygdala is involved in memory replay and encoding. During REM sleep, it is highly active, contributing to the emotional content of dreams. This state is...
- Integrative Rehabilitation for War-Related Polytrauma: A Narrative Review of Multidimensional Strategies and Implementation Challengesby Ji Sun on 15 Settembre 2026
CONCLUSIONS: Addressing the war-related rehabilitation gap requires integration of biomedical care, technology-assisted rehabilitation, and evidence-graded non-pharmacological adjuncts within a structured biopsychosocial framework. Future priorities include pragmatic, adapted trial designs (e.g., stepped-wedge or cohort-embedded designs, which are more feasible than classical RCTs under wartime conditions) for acupuncture in phantom limb pain, feasibility trials for robotic rehabilitation in...
- Connectome gradient dysfunction in earthquake-induced posttraumatic stress disorder and its association with gene expression and neurotransmitter profilesby Xun Zhang on 15 Settembre 2026
CONCLUSIONS: These findings highlight the dysfunctional connectome hierarchy in PTSD and its association with transcriptomic and molecular profiles, suggesting that early traumatization may more significantly impact the development of subcortical network. This work provides insight into the neurobiological basis of PTSD and indicates potential biomarkers for prediction and prevention.
- Positive Feedback Mechanisms in Pain Modulation and Chronic Painby Min Zhuo on 15 Settembre 2026
Feedback controls play important roles in biological systems, from the cellular level to systemic levels. Positive and negative feedback are two major feedback mechanisms. In this review, I will mainly investigate the positive feedback system involved in pain transmission, modulation and plasticity. At the level of the spinal cord, descending facilitation from different regions of supraspinal structures exert facilitatory effects on spinal nociceptive transmission. At the level of the cortex,...
- Reduced alpha-band phase coherence and cortical complexity in fibromyalgia: A tms-eeg exploratory studyby Anne Jakobsen on 3 Marzo 2026
CONCLUSION: Individuals with fibromyalgia have abnormal cortical connectivity compared with asymptomatic controls.
- Effect of Repetitive Transcranial Magnetic Stimulation on the Symptoms and Brain Imaging in Patients with Fibromyalgia Syndrome: A Randomized Controlled Pilot Trialby Laura Ackermann on 30 Agosto 2025
CONCLUSIONS: While these results may be due to small sample size and short treatment duration, the findings of increased FA after active rTMS and higher functional connectivity between DLPFC and cerebellum in responders should be further explored.
- Guidelines on Treating Fibromyalgia With Nonpharmacological Therapies in Chinaby Xuanlin Li on 11 Giugno 2025
Fibromyalgia is a prevalent chronic condition marked by widespread pain, fatigue, and other debilitating symptoms. This guideline provides evidence-based recommendations for nonpharmacological treatments, developed by a multidisciplinary expert group, including specialists in rheumatology, rehabilitation, pain management, traditional Chinese medicine (TCM), and evidence-based medicine. The guideline follows the RIGHT checklist and is registered with the International Practice Guideline Registry...
- Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agentsby Fernanda M Q Silva on 5 Ottobre 2024
Fibromyalgia syndrome (FMS) is a chronic disorder characterized commonly by widespread musculoskeletal pain and fatigue, predominantly affecting women, with its complexity often leading to underdiagnosis and complicating treatment effectiveness. Transcranial magnetic stimulation (TMS) metrics are potential markers to optimize FMS treatments; however, evidence is limited. Our study aimed to explore the relationship between cortical excitability and inhibition, assessed through TMS markers, and...
- The Impact of Obesity as a Peripheral Disruptor of Brain Inhibitory Mechanisms in Fibromyalgia: A Cross-Sectional Studyby Walter Fabris-Moraes on 13 Luglio 2024
Background/Objective: Obesity, characterized by chronic inflammation, may serve as a surrogate marker for more dysfunctional peripheral inflammation, potentially exacerbating FM symptomatology. Given this premise, this study aimed to investigate the effects of obesity as an effect modifier on neural and clinical variables, specifically those indexing pain-compensatory mechanisms in FM symptoms. Methods: A cross-sectional study was conducted with 108 participants who underwent a standardized TMS...
- No add-on therapeutic benefit of at-home anodal tDCS of the primary motor cortex to mindfulness meditation in patients with fibromyalgiaby Perianen Ramasawmy on 20 Giugno 2024
CONCLUSIONS: Our findings demonstrate no synergistic or add-on efffect of anodal tDCS of the left M1 compared to the proper effect of MM in patients with fibromyalgia.
- Neuromodulation in sleep disordersby Bashar Qatanany on 8 Settembre 2026
Sleep disorders are a growing global health issue with profound consequences on cardiovascular health, metabolic functioning, cognitive output and overall quality of life. Although there have been numerous clinical advances in brain-based treatments for sleep disorders, there are still a number of sleep disorders that are not well understood and need new treatment options to address the underlying neural mechanisms of sleep-wake regulation. Recent advances in neuroscience have highlighted...
- Comparative Treatment Response to Intermittent Theta Burst Stimulation in Long COVID-Associated Depression Versus Major Depressive Disorder: A Propensity Score-Matched Retrospective Cohort Studyby Yoshihiro Noda on 27 Agosto 2026
Background: Long COVID has emerged as a global health challenge characterized by persistent neuropsychiatric symptoms, including depression, fatigue, and cognitive impairment. Growing evidence indicates that sustained neuroinflammation, endothelial dysfunction, and fronto-limbic network disruption may underlie these symptoms, representing pathophysiological features distinct from major depressive disorder (MDD). Although repetitive transcranial magnetic stimulation (rTMS) is an established...
- Input-output curves demonstrate motor cortex hyperexcitability associated with cognitive impairment in Alzheimer's diseaseby Julia H Cho on 27 Agosto 2026
Recent studies suggest that cortical hyperexcitability in Alzheimer's disease (AD) may accelerate disease progression. However, the field lacks validated non-invasive methods to assay excitability in humans. In this study we used transcranial magnetic stimulation with electromyography to investigate mechanisms of motor cortical excitability in 63 biomarker-positive early-AD (ranging from mild cognitive impairment to mild dementia) participants and 72 cognitively unimpaired age-matched adults...
- Microstates and connectivity states reveal task-related network reorganization in Alzheimer's disease patientsby Ji-Won Kim on 15 Agosto 2026
CONCLUSIONS: Connectivity states indicated decreased task-related network stability in AD patients, which correlated with memory task performance. The findings support the neural efficiency hypothesis, which states that more efficient brain network optimization during tasks is linked to better performance.
- Identifying cognitive subgroups in older adults from community data with hierarchical cluster analysisby J D Hall on 14 Luglio 2026
This study applied Ward's hierarchical clustering to detailed neuropsychological data from a community-recruited sample of 180 older adults to identify naturally occurring cognitive subgroups and characterize multidomain cognitive heterogeneity beyond conventional mild cognitive impairment (MCI) criteria. Twenty-two demographically adjusted z-scores spanning memory, language, executive function, and attention/processing speed were submitted to Ward's method, and the resulting four-cluster...
- Towards a neurophysiological diagnostic marker of Alzheimer's disease using transcranial magnetic stimulation combined with electroencephalographyby Rachel Ben-Hayun on 8 Luglio 2026
BackgroundA scalable, objective measure of cortical function that differentiates Alzheimer's disease (AD) from other causes of cognitive impairment is still lacking. Transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) enables direct assessment of cortical reactivity.ObjectiveTo test whether left primary motor cortex (M1L) P30 amplitude captures AD-related excitability changes, distinguishes biomarker-confirmed AD patients from controls (CN) and from other non-AD...
- Metabolomic Profiling in Children with Sleep Disorders: An Exploratory Pilot Studyby Roberta Pintus on 15 Settembre 2026
Objectives: To analyze the metabolomic profile of children with sleep disorders to understand whether there are distinct and specific metabolic patterns related to the severity and type of sleep disorders (neurological or respiratory). Materials and Methods: This is an observational pilot study. Patients referred to our department for sleep disorders-both neurological and breath-related sleep disturbances-were enrolled. All patients received an anamnestic interview, clinical evaluation,...
- Neuroprotective and Neuromodulatory Potential of Valeriana officinalis, Passiflora incarnata, and Ginkgo biloba: Efficacy, Safety, and Regulatory Aspectsby Lidia Mielczarek on 15 Settembre 2026
Valerian (Valeriana officinalis L.), passionflower (Passiflora incarnata L.), and ginkgo (Ginkgo biloba L.) are among the most widely used medicinal plants in European phytotherapy, with well-documented traditional use for anxiety, insomnia, cognitive decline, attention-deficit/hyperactivity disorder (ADHD), and Parkinson's disease. This narrative review critically analyses available clinical, pharmacological, toxicological, and regulatory data on these three species in the context of central...
- Extended-Release Trazodone in Comorbid Major Depressive and Sedative-Hypnotic/Anxiolytic Use Disorders: A Real-World Preliminary Evaluation of Multidimensional Outcomesby Marco Di Nicola on 15 Settembre 2026
Objectives: Major depressive disorder (MDD) frequently co-occurs with substance use disorders, resulting in greater clinical severity and poorer outcomes. Sedative-hypnotic/anxiolytic agents (SHA) are commonly used to manage anxiety and insomnia, also in MDD. However, their long-term intake might lead to misuse and physical and cognitive complications. Trazodone, an antidepressant with sedative and anxiolytic properties, has been proposed as an option in SHA detoxification, but data on patients...
- Ayurveda Treatments for Insomnia: A Narrative Reviewby Martina Vendrame on 15 Settembre 2026
Background: Sleep disorders, particularly chronic insomnia (Nidranasha), represent an escalating global public health challenge associated with extensive neuropsychological and metabolic morbidities. While conventional pharmacotherapy provides immediate symptomatic relief, concerns regarding dependency, tolerance, and altered sleep architecture necessitate the evaluation of evidence-based complementary interventions. Ayurveda offers a comprehensive multi-modality framework for sleep health...
- Whole-Brain Diffusion MRI at 7T With Universal Multiband GRAPE pTx Pulsesby Marten Laufenberg on 15 Settembre 2026
CONCLUSION: Universal multiband GRAPE pTx pulses substantially improve signal homogeneity and SNR in whole-brain DWI at 7T, enabling more reliable diffusion microstructure mapping, particularly in the cerebellum.
- Hydrogel-Based Mechanical Sensors for Sleep Respiratory Monitoring: Recent Advances and Future Perspectivesby Yuanfeng Sun on 15 Settembre 2026
Sleep respiratory monitoring plays a crucial role in the early diagnosis and health management of sleep-related respiratory disorders. However, conventional monitoring devices often suffer from some critical issues, such as poor wearing comfort and insufficient capability for long-term continuous monitoring, hindering their applications in non-invasive and prolonged sleep monitoring. In recent years, hydrogel-based mechanical sensors have attracted increasing attention for sleep respiratory...
- Global under- and overprescribing of drugs-a scoping reviewby Lilly Josephine Bindel on 15 Settembre 2026
Inappropriate prescribing of drugs is a persistent issue with serious consequences for both patients and healthcare systems. This scoping review summarizes and assesses literature about over- and underprescribing of prescription drugs across various conditions. It outlines different levels of prescribing and associated factors, presenting a model to distinguish influencing factors across healthcare systems. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)...
- A new telos for migraine prevention: From potentiality to actuality through the IHS higher standardsby Luigi Francesco Iannone on 15 Settembre 2026
No abstract
- Association between spinal manipulative therapy and cervical artery dissection in patients with neck pain or headache: a retrospective cohort studyby Robert J Trager on 15 Settembre 2026
CONCLUSIONS: This study found no evidence of an increased risk of CeAD after chiropractor-administered cervical SMT compared with ibuprofen prescription in adults seeking care for new episodes of neck pain or headache. Despite the rarity of these events, all clinicians, including chiropractors, should maintain vigilance for CeAD symptoms. Additional multidisciplinary research is warranted to further address potential confounding and examine patient subgroups (e.g., migraine) and stroke.
- Correction: Baglioni et al. Non-Pharmacological Treatments in Paediatric Migraine. J. Clin. Med. 2024, 13, 1278by Valentina Baglioni on 15 Settembre 2026
In the original publication [...].
- Response to Galcanezumab in a Patient with Complex Neuropsychiatric Comorbidity: A Case Reportby Anna Anselmo on 15 Settembre 2026
Background: Migraine is a leading cause of disability worldwide and is frequently associated with psychiatric comorbidities that may influence pain perception and treatment response. Anti-CGRP monoclonal antibodies represent an effective preventive treatment, although response variability remains poorly understood, particularly in patients with complex neuropsychiatric profiles. Case Presentation: We report the case of a 49-year-old woman with migraine with a previously chronic course and...
- Static and dynamic functional connectivity of the bilateral insula in patients with migraine without aura: a resting-state fMRI studyby Guo-Yun Liu on 15 Settembre 2026
CONCLUSION: Combined rs-FC and dFCstd analyses revealed altered functional connectivity involving the insula in patients with MwoA. These connectivity patterns may reflect disturbances in neural circuits supporting pain processing, emotion regulation, and cognitive control, providing complementary imaging evidence for brain network dysfunction in MwoA.
- Food Allergies and Eating Disorders: An Exploration of Screening Prevalence and Associated Factors Among Adultsby Jessica Hine on 15 Settembre 2026
Background/Objectives: Food allergy (FA) affects up to 10% of adults and requires ongoing dietary vigilance that may increase vulnerability to eating disorders (EDs), yet evidence in adults remains limited. This study compared ED screening and history between adults with and without food allergy (FA), and explored factors associated with positive screening among those with FA. Methods: This cross-sectional study recruited 371 adults (134 with FA, 237 without) via an online survey. Positive...
- Behavioral Profiles of Exam Stress: Mapping Student Diet, Sleep, and Substance Useby Andreea-Sabina Butucaru on 15 Settembre 2026
Background: Academic pressure during examination periods is frequently reported alongside irregular lifestyle behaviors. The study aimed to explore the interplay between habitual eating behaviors, sleep quality, and self-reported stimulant use and coping adaptations specifically during examination periods among healthcare university students. Methods: This cross-sectional study included 265 university students (Mage = 22.00, SD = 4.46). Dietary behaviors and sleep quality were assessed using the...
- High- and Low-Calorie Food Cues, Visual Attention, and Subclinical Eating Pathology in University Students Assessed by Eye Trackingby Csongor István Szepesi on 15 Settembre 2026
Background/Objectives: Eating disorders are increasingly conceptualized as information-processing disorders characterized by attentional biases toward food-related stimuli. However, whether such biases are already detectable in subclinical, non-treatment-seeking populations remains unclear. This study examined whether subclinical eating pathology, assessed with the Eating Attitudes Test-26 (EAT-26), is associated with distinct patterns of visual attention toward high- and low-calorie food images...
- Integrative Nutritional Strategies for Performance, Recovery, and Weight Management in Taekwondoby Adam Tawfiq Amawi on 15 Settembre 2026
Taekwondo is a high-intensity, intermittent, weight-category combat sport requiring repeated explosive actions, rapid decision-making, and effective recovery between bouts. These demands, combined with congested competition schedules and weight-management requirements, make nutrition important for both performance and athlete health. This narrative review provides an evidence-informed synthesis of nutritional strategies relevant to taekwondo performance, recovery, and weight management by...
- Associations of Diabetes-Related Distress, Disordered-Eating Risk, and Self-Perceived Health with Glycemic Outcomes in Adolescents with Type 1 Diabetes: An Exploratory Cross-Sectional Studyby Marta García-Poblet on 15 Settembre 2026
Background/Objectives: Adolescents with type 1 diabetes mellitus (T1DM) are particularly vulnerable to psychological distress, disordered-eating (DE) risk and negative self-perceived health status (SPHS), which may compromise metabolic control and self-care. Although these factors have been studied individually, the usefulness of brief and clinically feasible screening tools to detect these dimensions remains underexplored. This study aimed to: (1) examine associations between distress, DE risk...
- Prevalence and Clinical Correlates of Autistic Traits Across Eating Disorder Diagnoses: A Retrospective Analysis of Clinical Service Databy Adia Meyer on 15 Settembre 2026
Background: Autistic traits are overrepresented among individuals with anorexia nervosa (AN) and are associated with greater eating disorder (ED) psychopathology, psychological distress, and work and social functioning difficulties in this population. However, less is known about the prevalence and clinical associations of autistic traits in other ED presentations, such as bulimia nervosa (BN). This study examined the prevalence of autistic traits and their associations with ED psychopathology,...
- A Ternary Flavonoid Formulation Mitigates Fractional Radiation-Induced Brain Injury via Transcriptomic Reprogramming and Synaptic Protectionby Yuanbing Zhu on 15 Settembre 2026
CONCLUSIONS: The rationally designed ternary flavonoid formulation (QLI) provides potent neuroprotection against fractional RIBI. By resolving neuroinflammation, alleviating synaptic plasticity suppression, and normalizing stress-induced transcriptomic disruptions, QLI represents a promising multi-target experimental formulation with the potential to mitigate radiotherapy-associated neurological side effects.
- Psychological experiences of unplanned interruption of patient-controlled intravenous analgesia in adult postoperative patients: A qualitative studyby Jiao Qin on 15 Settembre 2026
This qualitative study aimed to explore the psychological experiences of adult postoperative patients who unplanned discontinued patient-controlled intravenous analgesia (PCIA), based on the stress and coping theory and the Activating event, Beliefs, Consequences emotion theory. The findings are intended to provide insights for developing individualized analgesia management and psychological interventions in clinical practice. Employing a purposive sampling strategy, adult patients who...
- Perceived Facilitators and Barriers Inform Young Adult Cancer Survivors' Preferences for Physical Activity and Diet Interventions: A Qualitative Studyby Rashida K Jones on 15 Settembre 2026
Purpose: Young adult cancer survivors aged 20-30 years are at increased risk for chronic health conditions, influenced by modifiable lifestyle behaviors. Many do not meet the American Cancer Society's guidelines for physical activity and healthy eating. Guided by Social Cognitive Theory, this qualitative study explored the facilitators and barriers to healthy lifestyle behaviors among a racially and ethnically diverse sample of young adult cancer survivors aged 20-30 years to inform tailored...
- RNA-Based Therapeutics in Genetic Neurodevelopmental Disorders: Bridging Molecular Genetics and Precision Medicineby Ina-Ofelia Focșa on 15 Settembre 2026
Genetic neurodevelopmental disorders (NDDs) encompass a heterogeneous group of conditions characterized by impaired cognitive, behavioral, and neurological development resulting from pathogenic variants affecting brain development and synaptic function. Advances in molecular genetics and next-generation sequencing have significantly expanded the understanding of the genetic architecture underlying disorders such as Rett syndrome (RTT), Fragile X syndrome (FXS), Angelman syndrome (AS), and autism...
- Animal-Assisted Therapy in Dementia: A Systematic Review and Meta-Analysis of Cognitive, Affective, and Behavioral Outcomesby Man Amanat on 15 Settembre 2026
Background/Objectives: Behavioral and psychological symptoms of dementia (BPSD) are common and represent major drivers of caregiver burden and healthcare utilization. Animal-assisted therapy (AAT) is used as a non-pharmacological intervention in dementia care, yet quantitative evidence of its efficacy remains inconsistent. We systematically evaluated the effects of AAT on cognitive, affective, and behavioral outcomes in individuals with dementia. Methods: Following PRISMA 2020 guidelines, we...
- Trajectories of Self-Awareness Across the Alzheimer's Disease Spectrum: A Systematic Review of Its Potential Contribution to Early Diagnosisby Anastasia Tsouvala on 15 Settembre 2026
Background/Objectives: Self-awareness constitutes a key metacognitive construct supporting self-regulation and adaptive functioning in aging. This systematic review examined how self-awareness fluctuates across the Alzheimer's disease (AD) continuum and explored its associations with cognitive performance and neuroimaging markers. Methods: A systematic search was conducted in databases including PubMed, Scopus, Science Direct and Web of Science covering the period from 2016 to 2026, and the...
- Non-invasive brain stimulation in amyotrophic lateral sclerosis: a systematic review and meta-analysis of transcranial direct current stimulation and transcranial magnetic stimulationby Bassel Alrabadi on 10 Settembre 2026
CONCLUSION: Noninvasive brain stimulation in ALS does not significantly improve functional outcomes, but induces measurable neurophysiological changes with a strong safety profile. Further studies should optimize protocols and identify responsive subgroups.
- Advanced imaging-integrated rTMS therapy for frontal network recovery after traumatic brain injuryby Nan Hu on 9 Settembre 2026
CONCLUSION: High-frequency left-DLPFC rTMS exposure was associated with improved executive recovery and measurable frontal-network modulation after traumatic brain injury. These findings suggest that multimodal neurophysiological and imaging biomarkers may provide useful measures of target engagement for future prospective studies. Given the retrospective observational design, modest sample size, and short-term follow-up, causal inferences regarding treatment effects or biomarker-guided...
- Transcranial Magnetic Stimulation for Patients with Exposure Therapy Resistant Obsessive-Compulsive Disorder (TETRO): Study Protocol for a Multicenter Randomized Controlled Trialby Tjardo S Postma on 9 Settembre 2026
CONCLUSIONS: To our knowledge, this study is the first adequately powered randomized controlled trial examining efficacy, cost-effectiveness, and mechanism of action of rTMS for OCD as adjuvant therapy to ERP. In case of efficacy and/or cost-effectiveness, it will pave the way for rTMS as insured health care for adults with OCD in the Netherlands, and possibly other European countries. Furthermore, this trial will provide insight into the mechanisms of treatment response to intensive ERP, with...
- Transcranial Magnetic Stimulation Combined With Electroencephalography Analysis Suggest Time-Dependent and Region-Specific Modulation of Cortical Excitability During Acute Alcohol Intoxicationby Virve Kekkonen on 5 Settembre 2026
CONCLUSIONS: The results suggest time-dependent and region-specific modulation of cortical excitability during acute alcohol intoxication. Alcohol's effects are dynamic, regionally heterogeneous, and not limited to simple global suppression. TMS-EEG offers a promising tool for assessing alcohol-related changes in cortical functions.
- Focused Narrative Review: Non-Pharmacological, Noninvasive Neurostimulation or Neuromodulation Treatment of Ocular Neuropathic Painby Louis Tong on 4 Settembre 2026
Ocular neuropathic pain is typically treated with local anti-inflammatory and neuroregenerative agents, and psychological approaches such as cognitive behavioral treatment, as well as systemic pharmacological medications and nerve blocks. In recalcitrant cases, neurostimulation or neuromodulation may be considered. In this review, we evaluate the existing literature for the use of non-invasive forms of neurostimulation: home-based extra nasal neurostimulation (iTear100), extracranial direct...
- Physical Therapies and Neuromodulation for Treatment-Resistant Schizophrenia: A Review of Potential Mechanisms, Efficacy, and Safetyby Haiqiang Zhao on 30 Agosto 2026
Antipsychotic medications remain the conventional treatment for treatment-resistant schizophrenia (TRS), yet some patients exhibit poor responses. Due to the limitations of pharmacological interventions, physical therapies are increasingly recognized as essential supplements in managing TRS. This article systematically examines the current clinical applications and research advances of physical therapeutic techniques for TRS. Existing evidence suggests that electroconvulsive therapy (ECT),...
